Talk:Xanthohumol
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error in biosynthesis figure
[edit]Hi. I was looking at the entry on "Xanthohumol" (https://en.wikipedia.org/wiki/Xanthohumol) and noted that there was an error in the figure. The compound annotated as L-phenylalanine is incorrectly drawn. I cannot change it because it is a jpg. If the original chemdraw file was available I could fix it but I would need to have the original file. Otherwise I have to draw the whole figure from scratch.
Removed statement
[edit]The sourced statement quoted below was removed by someone. It is recorded here for posterity.
In preliminary research, xanthohumol had free radical scavenging and anticancer properties,[1] immune-supporting activity, improved cognitive flexibility,[2] and inhibited platelet aggregation.[3]
References
- ^ Mol Cancer Ther. 2002 Sep;1(11):959-69. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. https://www.ncbi.nlm.nih.gov/pubmed/12481418
- ^ https://www.ncbi.nlm.nih.gov/pubmed/25192637 Behav Brain Res. 2014 Sep 1;275C:1-10. doi: 10.1016/j.bbr.2014.08.045. Xanthohumol improved cognitive flexibility in young mice.
- ^ Lee; et al. (May 2012). "Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets". Evid Based Complement Alternat Med. 2012: 852362. doi:10.1155/2012/852362. PMC 3352669. PMID 22611436.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: unflagged free DOI (link)
--IO Device (talk) 15:46, 24 September 2014 (UTC)
Wishful thinking (scant literature)
[edit]List of potentially useful references. However, Ferk 2016 appears to be the only published clinical trial related to a health function! David notMD (talk) 10:15, 23 March 2017 (UTC)
Ferk F, Mišík M, et al. Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials. Mol Nutr Food Res. 2016;60(4):773-786.
Liu M, Hansen PE, et al. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules. 2015;20(1):754-779.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front Physiol. 2015;6:140.
Chen X, Mukwaya E, Wong MS, Zhang Y. A systematic review on biological activities of prenylated flavonoids. Pharm Biol. 2014;52(5):655-60.
van Breemen RB, Yuan Y, et al. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Mol Nutr Food Res. 2014;58(10):1962-69.
Bolca S, Li J, et al. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010;54(Suppl 2):S284-94.
Magalhães PJ, Carvalho DO, et al. Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat Prod Commun. 2009;4(5):591-610.
Possemiers S, Bolca S, et al. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr. 2006;136(7):1862-7.
Legette L, Karnpracha C, et al. Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res. 2014;58(2):248-255.
Pichler C, Ferk F, et al. Xanthohumol prevents DNA damage by dietary carcinogens: results of a human intervention trial. Cancer Prev Res. 2017;10(2):153-160.
Abdi F, Mobedi H, Roozbeh N. Hops for menopausal vasomotor symptoms: mechanisms of action. J Menopausal Med. 2016;22(2):62-64.
- Shown here among NIH-registered studies, two by Oregon State University are completed (but no published reports, possibly indicating no or low-interest results), with one ongoing Phase I study for safety in women. JF Stevens, Oregon State, (PI lead for 2 of the NIH-registered studies) has been tracking toward clinical trials since the late 1990s. --Zefr (talk) 16:20, 23 March 2017 (UTC)