Template:Did you know nominations/Augmented renal clearance

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The following is an archived discussion of the DYK nomination of the article below. Please do not modify this page. Subsequent comments should be made on the appropriate discussion page (such as this nomination's talk page, the article's talk page or Wikipedia talk:Did you know), unless there is consensus to re-open the discussion at this page. No further edits should be made to this page.

The result was: promoted by SL93 (talk) 18:01, 22 August 2020 (UTC)

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Augmented renal clearance

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  • ... that a person may display augmented renal clearance, or increased kidney function, when severely ill? Source: Cook, Aaron M.; Hatton‐Kolpek, Jimmi (March 2019). "Augmented Renal Clearance". Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 39 (3): 346–354. doi:10.1002/phar.2231.
    • ALT1:... that some medicines, such as vancomycin, may require higher doses in critically ill patients, due to augmented renal (kidney) clearance? Source: Udy, Andrew A.; Roberts, Jason A.; Boots, Robert J.; Paterson, David L.; Lipman, Jeffrey (January 2010). "Augmented Renal Clearance: Implications for Antibacterial Dosing in the Critically Ill". Clinical Pharmacokinetics. 49 (1): 1–16. doi:10.2165/11318140-000000000-00000.
  • Reviewed: [[]]
  • Comment: Happy to work on hooks - kinda odd to say "augmented renal clearance" in a hook, because it's quite technical - but tried to avoid piping the link. This is only my fourth DYK nom and I'll be sure to review another before making a 5th.

Moved to mainspace by Berchanhimez (talk). Self-nominated at 22:41, 10 August 2020 (UTC).

  • Reviewing
  • Article is new enough, long enough, well written, neutral and supported by inline citations.
  • No copyvio on Earwig.
  • Hooks are short enough, correctly formatted and supported by inline citations. I don't think that including the title of the article is necessarily too technical. If you wanted a simpler non-technical hook what about something like 'In critical illness men under 50 years are at higher risk of augmented renal clearance' I think yours are better and I'm happy to approve them.
  • QPQ exempt

. Could I suggest the following edits before approval. Place the 'History' section first. This makes the concept easier to understand. Change heading 'Symptoms and signs' to 'Diagnostic features'. There aren't symptoms or physical signs. Change heading 'Screening' to 'Risk factors and screening'. I think that section would be clearer if there was an indication of how these factors influenced risk e.g. 'Male gender - increases risk. Age under 50 increases risk, Presence leukaemia - increases risk, Low serum creatinine increases risk, Low APACHE score increases risk, Low SOFA score - increases risk. May want to think about how best to format those.Papamac (talk) 14:09, 11 August 2020 (UTC)

  • @Iainmacintyre: thanks for the suggested edits - and confirmation the title is okay to include in the hook - I've made the edits to headings as you suggested, and I'm okay with the hooks as they are with or without the clarification that renal = kidney. I'm fine with them if you are then. I had planned to work more on the risk factors/screening sections but am still on the search for sourcing - going to check some resources I have "in person" access to (well, I have to be in a specific place to access) when I can this week and work on it. The risk factors aren't part of my suggested hooks, but if you want to wait for me to get some more work done on it I understand. -bɜ:ʳkənhɪmez (User/say hi!) 14:43, 11 August 2020 (UTC)
 :::* Thanks. I think your work on the risk factors should improve it further. Of the 2 hooks I think ALT1 is preferable. As of now good to go. Papamac (talk) 15:31, 11 August 2020 (UTC)
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