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Portrait of Simonetta Vespucci is an oil painting on canvas completed by the Italian Renaissance painter Piero di Cosimo around 1480 or 1490. It depicts Simonetta Vespucci, a Genoese noblewoman who was renowned in Florence for her beauty. The painting is held at the Musée Condé in Chantilly, France.Painting: Piero di Cosimo