Template:Side effects of cyproterone acetate in the SExual-HOrmonal Surveillance STudy (SEHOST)

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Side effects of cyproterone acetate in the SExual-HOrmonal Surveillance STudy (SEHOST)
Side effect	Males (136 mg/day)^[a] (n = 1248) (%)	Females (18 mg/day)^[a] (n = 1258) (%)	Total (77 mg/day)^[a] (n = 2506) (%)
Elevated liver enzymes^[b]	12.5	3.6	9.6
Gynecomastia, breast pain	4.9	1.0	2.9
Overweightness, weight gain	0.9	4.1	2.5
Headache, migraine	–	3.4	1.7
Depression, anxiety, nightmares, mood swings	1.0	1.8	1.4
Gastrointestinal dysfunction	0.2	2.3	1.2
Thyroid dysfunction	0.2	1.8	1.0
Skin changes (pigmentation, chloasma, others)	0.3	1.4	0.8
Edema	–	1.1	0.6
Adrenal insufficiency or hyperplasia	0.2	0.8	0.5
Tiredness, lethargy, apathy	0.6	0.6	0.6
Alopecia, hair growth	0.2	0.2	0.2
Increased asthma attack rates	–	0.3	0.2
Osteoporosis	0.2	0.08	0.2
More frequently prone to attacks	0.2	0.2	0.2
Diabetes mellitus	0.08	0.08	0.08
Total (excluding elevated liver enzymes)	9.0	19.1	14.0
Notes: Data from the SExual-HOrmonal Surveillance STudy (SEHOST), a long-term pharmacoepidemiologic active surveillance study. The sample included males and females age 3 to 75 years with precocious puberty, hyperandrogenism, sexual deviance, and/or transgenderism; prostate cancer was not included. Sources: ^[1]^[2]

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