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Template:Side effects of estrogen plus high- versus low-dose cyproterone acetate in women

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Side effects of estrogen plus high- versus low-dose cyproterone acetate in women
Side effect High-dose[a]
(n = 602) (%)
Low-dose[b]
(n = 226) (%)
Fatigue 22.0 13.0
Weight gain (>2 kg or >4.4 lbs) 18.5 5.5
Decreased libido 10.0 6.0
Breast discomfort 9.2 15.0
Nausea 9.0 3.9
Headaches 7.3 10.4
Depression 5.1 2.0
Irregular uterine bleeding 3.5 7.2
Sleep disturbance 3.5
Thrombophlebitis 1.0 3.0
Chloasma 0.9
Constipation 0.5
Thrombosis 0.15 0.9
Heavy legs or cramps 4.6
Footnotes:
  1. ^ Reverse sequential regimen: In women with hirsutism, cyproterone acetate 100 mg/day from days 5 to 14 of the menstrual cycle and ethinylestradiol 50 μg/day from days 5 to 25 of the cycle.
  2. ^ Diane: In women with hirsutism, cyproterone acetate 2 mg/day and ethinylestradiol 50 μg/day from days 5 to 25 of the cycle.
Sources: [1][2][3][4][5]