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Thyroglobulin domain

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Thyroglobulin type-1 repeat
Thyroglobulin type-1 domain
Identifiers
SymbolThyroglobulin_1
PfamPF00086
InterProIPR000716
PROSITEPDOC00377
SCOP21icf / SCOPe / SUPFAM
CDDcd00191
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1icfI:213-271 1l3hA:213-271 1rmjA:163-234 1zt3A:176-251 1zt5A:176-251

Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain

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CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1; TACSTD2; TG;

References

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  • Guncar G, Pungercic G, Klemencic I, Turk V, Turk D (February 1999). "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S". The EMBO Journal. 18 (4): 793–803. doi:10.1093/emboj/18.4.793. PMC 1171172. PMID 10022822.
  • Molina F, Bouanani M, Pau B, Granier C (August 1996). "Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families". European Journal of Biochemistry. 240 (1): 125–33. doi:10.1111/j.1432-1033.1996.0125h.x. PMID 8797845.
This article incorporates text from the public domain Pfam and InterPro: IPR000519