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Trans-resveratrol di-O-methyltransferase

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Trans-resveratrol di-O-methyltransferase
Identifiers
EC no.2.1.1.240
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Trans-resveratrol di-O-methyltransferase (EC 2.1.1.240, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + trans-resveratrol 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
(1a) S-adenosyl-L-methionine + trans-resveratrol S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

References

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  1. ^ Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P (November 2008). "A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine". Plant Physiology. 148 (3): 1630–9. doi:10.1104/pp.108.126003. PMC 2577258. PMID 18799660.
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