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Transcription factor IIIB 50 kDa subunit

From Wikipedia, the free encyclopedia
BRF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRF2, BRFU, TFIIIB50, RNA polymerase III transcription initiation factor 50 kDa subunit, RNA polymerase III transcription initiation factor subunit, BRF2 RNA polymerase III transcription initiation factor subunit
External IDsOMIM: 607013; MGI: 1913903; HomoloGene: 10127; GeneCards: BRF2; OMA:BRF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018310

NM_025686

RefSeq (protein)

NP_060780

NP_079962

Location (UCSC)Chr 8: 37.84 – 37.85 MbChr 8: 27.61 – 27.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.[5][6][7]

Function

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This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104221Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031487Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F (Aug 2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
  6. ^ Cabart P, Murphy S (Nov 2001). "BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein". J Biol Chem. 276 (46): 43056–64. doi:10.1074/jbc.M108515200. PMID 11564744.
  7. ^ a b "Entrez Gene: BRF2 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like".

Further reading

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