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ULBP2

From Wikipedia, the free encyclopedia
ULBP2
Identifiers
AliasesULBP2, N2DL2, RAET1H, ALCAN-alpha, NKG2DL2, UL16 binding protein 2, RAET1L
External IDsOMIM: 605698; HomoloGene: 130743; GeneCards: ULBP2; OMA:ULBP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025217

n/a

RefSeq (protein)

NP_079493

n/a

Location (UCSC)Chr 6: 149.94 – 149.95 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.[3][4] ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus.[3][4] The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.[3][4]

ULBP2 functions as a stress-induced ligand for the NKG2D killer activation receptor on natural killer cells.[5][4]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131015Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b c Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
  4. ^ a b c d Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.
  5. ^ Song P, Zhao Q, Zou M (2020). "Targeting senescent cells to attenuate cardiovascular disease progression". Ageing Research Reviews. 60: 101072. doi:10.1016/j.arr.2020.101072. PMC 7263313. PMID 32298812.

Further reading

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