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Several selective ligands for the oxytocin receptor have been developed, but close similarity between the oxytocin and related vasopressin receptors make it difficult to achieve high selectivity with peptide derivatives.[1][2], recently however very selective non-peptide oxytocin antagonist have been developed.


References

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  1. ^ Chini B, Manning M (August 2007). "Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges". Biochemical Society Transactions. 35 (Pt 4): 737–41. doi:10.1042/BST0350737. PMID 17635137.
  2. ^ Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G (2008). "Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents". Progress in Brain Research. Progress in Brain Research. 170: 473–512. doi:10.1016/S0079-6123(08)00437-8. ISBN 9780444532015. PMID 18655903.{{cite journal}}: CS1 maint: multiple names: authors list (link)