User:BlakePierce/Spike-and-wave

Wikipedia Proposal: Spike-and-Wave

The following is a proposal for a project on spike-and-wave patterns done by Mike Javorski, Tyler Popp, and Blake Pierce. Each member will be assigned specific sections from the outline. We will meet once a week, after class to discuss and review our individual additions made to the wikipedia page.

General Definition and Introduction

• What is spike-and-wave?
  • Pictures of normal EEG and of EEG during absence seizure
• The pattern is generally seen in which diseases?
• Who is generally affected and what does it mean/how is it abnormal?
• Average pattern in normal human/animals and average of those affected?

Function and Mechanisms Involved in Spike-and-Wave

• Anatomy and function of Cerebral Cortex (Avoli article)
  • Initiates in the cortex
  • Sharpness of spike may correspond to decrease in size of the epileptogenic zone (Jaseja article)
• Anatomy and function of Thalamus (Avoli article)
  • Still equal in importance
• How they work together

Absence Seizures

• Brief intro of seizures, what goes on in the brain
• Absence seizures
  • Definition and how they are different from other seizures
  • Atypical/typical

Drug Therapies and Experiments to Remedy Spike-and-Wave

• (AEDs) antiepileptic drugs (Ferro article)
• Experiments done on mice
• Valproate and Ethosuximide for the treatment of childhood absence seizures (Beydoun article)

References

1. Alberti, A. "Seizures." Rev. of Absence Seizures. Front Neurol Neurosci 2012: n. pag.PubMed. Web. 16 Sept. 2012.

2. Avoli, M. "A Brief History on the Oscillating Roles of Thalamus and Cortex in Absence Seizures." Rev. of Spike-and-Wave. Epilepsia (2012): n. pag. PubMed. Web. 16 Sept. 2012.

3. Beydoun, A., and J. D'Souza. "Treatment of Idiopathic Generalized Epilepsy - a Review of the Evidence." Rev. of Spike-and-Wave. Expert Opin Pharmacother June 2012: n. pag. PubMed. Web. 16 Sept. 2012.

4. Ferro, J. M., and Pinto, F. "Poststroke Epilepsy: Epidemiology, Pathophysiology and Management." Rev. of Spike-and-Wave. Drugs Aging 2004: 639-53. PubMed. Web. 16 Sept. 2012.

5. Jaseja, Harinder, and Bhanu Jaseja. "EEG Spike versus EEG Sharp Wave: Differential Clinical Significance in Epilepsy." Epilepsy & Behavior 25.1 (2012): 137. PubMed. Web. 16 Sept. 2012.

6.Vaudano, Anna E, Laufs H, Kiebel SJ, Carmichael DW, Hamandi K, et al."Causal Hierarchy within the Thalamo-Cortical Network in Spike and Wave Discharges." PLoS ONE 4.8 (2009): PubMed. Web. 14 Sept. 2012.