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User:Chrisereae/Murine Cytomegalovirus

From Wikipedia, the free encyclopedia

Murine Cytomegalovirus(MCMV, Murid Herpesvirus 1, MuHV1) is a virus of Herpesviridae family which infects the common house mouse, Mus musculus. MCMV is a species of the genus Muromegalovirus within the family Betaherpesvirinae

Taxonomy

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Murine Cytomegalovirus and Rat Cytomegalovirus are to date the only classified members of the Muromegalovirus within the Betaherpesvirinae.

Biology

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Model for Cytomegalovirus Infection

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Cytomegaloviruses exhibit strict host-species specificiy, and no animal model currently exists for Human Cytomegalovirus (HCMV, HHV-5). Because of this, in vivo studies of Cytomegalovirus infection are carried out using either Murine Cytomegalovirus, Rat Cytomegalovirus (Murid Herpesvirus 2) or Guinea Pig Cytomegalovirus; MCMV is the most commonly used model. Though the genomes of MCMV and Human Cytomegalovirus HCMV are colinear, only 78 of MCMV's >170 predicted open reading frames are conserved in HCMV, 40 of which are conserved among all mammalian and avian herpesviruses. [1]


References

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  1. ^ 1

Fields Virology, 5th Edition. Chapter 69 "Cytomegaloviruses"

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