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Dr. P. Vijayaraghavan M. Sc., M Phil., Ph. D
Broad research Area: Biological Science
Focused Research Area: Microbial enzymes, Probiotics, Secondary metabolites, Essential Oil, Nanomaterials, Phytochemisty, COVID-19, Cancer diagnosis; Environmental Management, Environmental Contaminants; Biodegradation.
Major Contribution: A new screening method was developed for the detection of protease activity, cow dung was established as a low cost substrate for biomolecule production.
AWARDS AND HONOURS 2
CSIR Senior Research Fellowship Award was received in the year 2012 from Council of Scientific and Industrial Research, New Delhi, India.
Best Research Paper Award – Department of Environment, Government of Tamilnadu for the Year 2015.
Research Papers: 75 CUMULATIVE IMPACT FACTOR > 175
Selected papers:
1. Ponnuswamy Vijayaraghavan, Tharmaraj Renisheya Joy Jebamalar, Samuel Gnana Prakash Vincent. Biosynthesis optimization and purification of a solvent stable alkaline serine protease from Halobacterium sp. Ann Microbiol. 62 (1): 403-410.
2. Ponnuswamy Vijayaraghavan, Samuel Gnana Prakash Vincent, Cow dung as a novel, inexpensive substrate for the production of a halo-tolerant alkaline protease by Halomonas sp. PV1 for eco-friendly applications, Biochem Eng J 69 (2012) 57– 60.
3. Ponnuswamy Vijayaraghavan Aija Vijayan, A. Arun, J. Jenisha, Samuel Gnana Prakash Vincent. Cow dung: A potential biomass substrate for the production of detergent-stable dehairing protease by alkaliphilic Bacillus subtilis strain VV. 1. SpringerPlus 2012, 1:76 doi:10.1186/2193-1801-1-76 .
4. Ponnuswamy Vijayaraghavan, Sophia Lazarus, Samuel Gnana Prakash Vincent. De-hairing protease production by an isolated Bacillus cereus strain AT under solid-state fermentation using cow dung: Biosynthesis and properties. Soudi Journal of Biological Scienceshttp://dx.doi.org/10.1016/j.sjbs.2013.04.010
5. P. Vijayaraghavan and S. G Prakash Vincent, Medium Optimization for the Production of Fibrinolytic Enzyme by Paenibacillus sp. IND8 Using Response Surface Methodology, The Scientific World Journal, 2014, Article ID 276942, 9 pages, http://dx.doi.org/10.1155/2014/276942.
6. Ponnuswamy Vijayaraghavan and Samuel Gnana Prakash Vincent. Statistical Optimization of Fibrinolytic Enzyme Production Using Agroresidues by Bacillus cereus IND1 and Its Thrombolytic Activity In Vitro, BioMed Research International
Volume 2014 (2014), Article ID 725064, 11 pages
7. Ponnuswamy Vijayaraghavan, S. G. Prakash Vincent and G. S. Dhillon. Solid-substrate bioprocessing of cow dung for the production of carboxymethyl cellulase by Bacillus halodurans IND18. Waste Management 48 (2016) 513–520. 8. P. Vijayaraghavan and S.G. Prakash. A low cost fermentation medium for potential fibrinolytic enzyme production by a newly isolated marine bacterium, Shewanella sp. IND20$ Vincent. Biotechnology Reports 7 (2015) 135–142.
9. Ponnuswamy Vijayaraghavan1*, Arumugaperumal Arun2, Naif Abdullah Al‑Dhabi3, Samuel Gnana Prakash Vincent1, Mariadhas Valan Arasu3* and Ki Choon Choi. Novel Bacillus subtilis IND19 cell factory for the simultaneous production of carboxy methyl cellulase and protease using cow dung substrate in solid‑substrate fermentation Biotechnol Biofuels (2016) 9:73.
10. Ponnuswamy Vijayaraghavan, Arumugaperumal Arun, Samuel Gnana Prakash Vincent, Mariadhas Valan Arasu, and Naif Abdullah Al-Dhabi. Cow Dung Is a Novel Feedstock for Fibrinolytic Enzyme Production from Newly Isolated Bacillus sp. IND7 and Its Application in In Vitro Clot Lysis. Frontiers in Microbiology, 2016, 7: 361. doi: 10.3389/fmicb.2016.00361
11. Ponnuswamy Vijayaraghavan, Samuel Gnana Prakash Vincent, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi. Bioconversion of agro-industrial wastes for the production of fibrinolytic enzyme from Bacillus halodurans IND18: Purification and biochemical characterization. Electronic Journal of Biotechnology 20 (2016) 1–8. 12. ValanArasu, M., Vijayaraghavan, P, Ilavenil, S., Al-Dhabi, N.A., Choi, K.C., Essential oil of four medicinal plants and protective properties in plum fruits against the spoilage bacteria and fungi. Industrial Crops and Products. 2019; 133: 54-62. 13. ValanArasu, M., Arokiyaraj, S., Vijayaraghavan, P., JebaKumar, T.S., Duraipandiyan, V., Al-Dhabi, N.A., Kaviyarasu, K. One step green synthesis of larvicidal, and azo dye degrading antibacterial nanoparticles by response surface methodology. Journal of Photochemistry and Photobiology, B: Biology, 2019, 190: 154-162. 14. Vijayaraghavan, P., JebaKumar, S., ValanAradu, M., Al-Dhabi, N.A., Simultaneous production of commercial enzymes using agro industrial residues by statistical approach. Journal of Science Food Agri 2019, DOI 10.1002/jsfa.9436 15. Al-Dhanim, K.A., Mahboob, S., Vijayaraghavan, P., Al-Misned, F. A., Kim, Y.O., Kim, H-J., Sub-lethal effect of synthetic pyrethroid pesticide on metabolic enzymes and protein profile of non-profit Zebra fish, Danio rerio. Saudi Journal of Biological Sciences, 2020, 27, 441-447. 16. Kim, H-J., Mahboob, S., Vijayaraghavan, P., Al-Dhanim, KA., Al—Misned, F., Kim, Y.O., Ahmed, Z. Journal of King Saud University-Science,2020, 32, 1390-1394. 17. Atif, M., Ilavenil, S., Devanesan, S., AlSalhi, M.S., Choi, K-C., Vijayaraghavan, P., Alfuraydi, A., Alanazi, N.F., Essential oils of two medicinal plants and protective properties of jack fruits against the spoilage bacteria and fungi. Industrial Crops and Products. 2020, 147, 112239. 18. Al-Ansari, M., Kalaiyarasi, M., Almalki, M.A., Vijayaraghavan, P. Optimization of medium components for the production of antimicrobials and anticancer secondary metabolites from Streptomyces sp. AS11. Isolated from the marine environment. Journal of King Saud University-Science, 2020. 32, 1993-1998.
BOOK CHAPTER 2
1. P. Vijayaraghavan and S. G. Prakash Vincent, Agro-Industrial Wastes: An Inexpensive Raw Material for The Production of Useful Enzymes. Engendering Agriculture Development: Emerging Perspective, Issues, Challenges and Strategies, 136-145. ISBN: 978-81-906512-3-3. 2. Vijayaraghavan, P., Raj, S., Vincent, S., 2016. Industrial Enzymes: Recovery and Purification Challenges. In: Dhillon, G.Singh, Kaur, S. (Eds.), Agro-Industrial Wastes as Feedstock for Enzyme Production: Apply and Exploit the Emerging and Valuable Use Options of Waste Biomass. Academic Press, 95–110. ISBN: 9780128023921.
PROCEEDINGS 1 1. P. Vijayaraghavan, S. G. Prakash Vincent. Invitro development and seeding studies on Caridina pseudogracilirostris (Crustacea, dacepoda) egg: A new model organism in crustacean molecular research. New Horizon of Animal Science, Published by Zoological Society of India, Magadh University, Bodh Gaya, Bihar. Pp. 614-627.
MANUAL PUBLICATION 1 1. Laboratory manual on “Protein Electrophoresis”
INVITED TALKS 2 1. Invited by the Department of Microbiology, Malankara Catholic College to deliver a lecture on “Protein Electrophoresis” (August 2009). 2. Invited by the Department of Zoology, Nesamony Memorial Christian College, to deliver a lecture on “Electrophoresis” (July 2013). CONFERENCE ACTIVITY/PARTICIPATION 16 Paper presentation: 1. Presented a paper entitled “Agro-industrial wastes: An inexpensive raw material for the production of useful enzymes”, at Planning Commission of India Sponsored National Seminar Titled “Engendering Agriculture Development: Emerging Perspective, Issues, Challenges and Strategies” on 15th and 16th July 2011. 2. Presented a paper on “Bioconversion of agricultural biproducts for alpha amylase production and its apploication”, in the International Conference on “Recent Trends In Biotechnology” organized by the Research Department of Plant Biology and Plant Biotechnology and P.G Department of Biotechnology on 13th Jauary at Holycross College, Nagercoil. 3. Presented a paper entitled “Enzyme Technology: Purification Tactics”, at a National Symposium on Prospective Aspects of Microbial Biotechnology, organized by the Department of Zoology, The Standard Fireworks Rajaratnam College for Women, on 30th July – 1st August 2009. 4. Presented a paper entitled “Proteus mirabilis urease: Purification and its application”, at National Seminar on “Bio prospecting of microbes for potential applications” on 24th October, 2008. 5. Presented a paper entitled “Invitro development and seeding studies on Caridina pseudogracilirostris (crustacean, decapoda) egg: A new model organism in crustacean molecular research, at National Conference on Zoology, conducted at Vivekananda College, Kanyakumari, on 21st – 23rd December 2003. Participation: 1. Participated “Science Tamil National Conference” held at Vivekananda Kendra, Kanyakumari, on 7th August 2010, sponsored by Government of Tamilnadu. 2. Participated 97th Indian Science Congress held at Kerala University, Thiruvananthapuram, from January 3 to 7, 2010. 3. Participated in a State Level Symposium, conducted by Sivanthi Ddithanar College, Nagercoil, on 26th and 27th March 2010. 4. Participated in the International Symposium on “Second Green Revolution: Priorities, Programmes, Social and Ethical Issues” organized by the School of Biosciences, Mar Athanasios College for Advanced Studies, Tiruvalla held on 2 – 4 July, 2009. 5. Participated in First All India Conference of SRF held at Scott Christian College, Nagercoil, on March 13, 2004. 6. Participated in State Level Seminar on Applied Aspects of Industrial Biotechnology, conducted by Department of Plant Biology and Biotechnology, Holy Cross College, Nagercoil, on 10th October, 2003. 7. Participated in the National Symposium on Recent Trends in Biotechnology, conducted by Department of Biotechnology, Malankara Catholic College, Kaliakavilai, on 27th and 28th January 2003. 8. Participated in the International Conference on Advanced Technologies in Fisheries and Marine Sciences held at Noorul Islam College of Engineering, Thuckalay, held at 2 – 4 February 2001. 9. Participated national seminar on Bioinformatics, organized by Department of Microbiology, Malankara Catholic College, Kanyakumari District, held on 13th August 2004. 10. Participated state level seminar on Biotechnology and Biodiversity, organized by Department of Biotechnology, Annai Velankanni College, Kanyakumari District, held on 7th March 2008. 11. Particpiated seminar on “Clinical research in drug discovery process and emerging career opportunities”, organized by Xpression Biotek Pvt Ltd, and Consortium Clinical Research Pvt Ltd., Coimbatore, held on 22nd January 2009. TRAINING 1 Undergone a full time course of Advanced Training in “Chromatographic methods of analysis” for a weed from 27/09/2010 to 01/10/2010 at Advanced Training Institute, Chennai. WORK SHOP 3 Participated in the International workshop on improving skills on publishing in reviewed and indexed journals on 28th march, 2014, held at Manonmaniam Sundaranar University, Tirunelveli. Participated in the workshop on “International Nano-Characterization Techniques as Complementary Tools for Biomolecular Applications”, at Department of Nanotechnology, Noorul Islam Centre for Higher Education, Kumaracoil, sponsored by Department of Biotechnology, Government of India. Participated in the workshop on “Regeneration and stem cell biology” organized by Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, on 3rd – 6th December 2013.