User:Er1cah0p3/sandbox

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Five Pillars of Wikipedia[edit]

The Five Pillars of Wikipedia are as follows:

Wikipedia is an online encyclopedia
Wikipedia has a neutral point of view
Wikipedia is free content
Wikipedians should interact in a respectful and civil manner
Wikipedia does not have firm rules^[1]

Summary of Characteristics of Target Article[edit]

The target quality that we are aiming for in this class is at least a B level article but ideally we will be able to edit an article that will meet good article expectations. Both articles should be accessible and understood by a general audience, keeping in mind that Wikipedia is not only utilized by experts/scientists but by people from all educational backgrounds. Below is a brief summary of what each article should contain.

A Good Article should meet good article criteria including:

Being well written and verifiable, containing appropriate references and use of citations.
Needing minimal, if any, editing.
Containing substantial support but may not quite meet encyclopedic standards yet^[2].

A B Article will meet the B article criteria including:

Being adequately written and referenced.
Good structure, although this article may benefit from the help of a senior editor.
Good content but not yet complete.

Possible Genetic Variables in Systemic Sclerosis[edit]

Systemic sclerosis (SSc) is a disease involving worsening fibrosis of the skin and internal organs as well as marked vascular damage.^[3] The disease is often classified as either limited cutaneous scleroderma or diffuse cutaneous scleroderma with the diffuse form showing poorer prognosis.^[3] The disease has yet to have a clear genetic profile with the various forms of the disease often displaying different genetic components. While the IL6 gene variant IL6rs2069840*G seems to display protective qualities in the limited form,the gene variant IL6rs1800795*G seems to increase risk in the diffuse form.^[3] Moreover it was thought that the CD40 gene would display some association with systemic sclerosis considering that SSc patients showed higher levels of CD40 protein in both their plasma and surface skin fibroblasts.^[4] The research carried out by Teruel, etal however shows no correlation between the CD40 gene or its variants and the development of SSc.^[4] Clearly SSc is a complicated disease with multiple genetic variables that can be explored.

References:[edit]

^ http://en.wikipedia.org/wiki/Wikipedia:Five_pillars
^ http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Articles_for_creation/Grading_scheme
^ ^a ^b ^c Cénit MC, Simeón CP, Vonk MC; et al. (December 2012). "Influence of the IL6 gene in susceptibility to systemic sclerosis". J. Rheumatol. 39 (12): 2294–302. doi:10.3899/jrheum.120506. PMID 23027890. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
^ ^a ^b Teruel M, Simeon CP, Broen J; et al. (2012). "Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis". Arthritis Res. Ther. 14 (3): R154. doi:10.1186/ar3890. PMC 3446540. PMID 22731751. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

[1] ttp://en.wikipedia.org/wiki/Wikipedia:Five_pillars

[2] ttp://en.wikipedia.org/wiki/Wikipedia:WikiProject_Articles_for_creation/Grading_scheme

[pmid23027890-3] Cénit MC, Simeón CP, Vonk MC; et al. (December 2012). "Influence of the IL6 gene in susceptibility to systemic sclerosis". J. Rheumatol. 39 (12): 2294–302. doi:10.3899/jrheum.120506. PMID 23027890. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)

[pmid22731751-4] Teruel M, Simeon CP, Broen J; et al. (2012). "Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis". Arthritis Res. Ther. 14 (3): R154. doi:10.1186/ar3890. PMC 3446540. PMID 22731751. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

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