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KMaher123/Neural Fold
Chick embryo of thirty-three hours’ incubation, viewed from the dorsal aspect. X 30. (Neural fold labeled at center left, third from the bottom.)
Details
Carnegie stage9
Precursorneural plate
Gives rise toneural tube
Identifiers
Latinplica neuralis
Anatomical terminology

The Neural Fold is the structure, or fold, formed during the neurulation stage of development which forms the neural tube. While the neural fold is not a specific cell type, there are many defined types of cells and structures which are involved with the neural fold and folding.[1] Important molecules and proteins are responsible for the neural fold and there are documented disorders associated with problems with the formation of the neural tube categorized as neural tube defects.[2]

Introduction

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The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms[3] . This structure is associated with primary neurulation, meaning that it forms by the involution of tissue layers, rather than a clustering, and subsequent hollowing out, of individual cells (which is called secondary neurulation). In humans, the neural folds are responsible for the formation of the anterior end of the neural tube. The neural folds are derived from the neural plate, a preliminary structure consisting of elongated ectoderm cells. The folds give rise to neural crest cells, as well bringing about the formation of the neural tube. [3]

Origin

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In the embryo, the formation of the neural folds originates from an area called the Neural Ectoderm-Epidermal Ectoderm, or NE-EE. This region of the embryo is formed after gastrulation and is where the epithelial tissue of the embryo folds the neural crest and plate inward to form the neural tube and the neural crest cells, as shown in the thumbnail below. [4]

Folding Mechanism

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This diagram shows the folding progress of the neural plate and the surrounding ectoderm from beginning to the completion of the neural tube. Early in an embryo’s development, a strip of specialized cells called the notochord (A) induces the cells of the ectoderm directly above it to become the primitive nervous system (i.e., neuroepithelium). The neuroepithelium then wrinkles and folds over (B). As the tips of the folds fuse together, a hollow tube (i.e., the neural tube) forms (C)—the precursor of the brain and spinal cord. Meanwhile, the ectoderm and endoderm continue to curve around and fuse beneath the embryo to create the body cavity, completing the transformation of the embryo from a flattened disk to a three–dimensional body. Cells originating from the fused tips of the neuroectoderm (i.e., neural crest cells) migrate to various locations throughout the embryo, where they will initiate the development of diverse body structures (D).[5]

The formation of the neural fold is initiated by the release of calcium. The released calcium interacts with proteins that can modify the actin filaments in the outer epithelial tissue, or ectoderm, in order to induce the dynamic cell movements necessary to create the fold. [6] These cells are held together by cadherin (specifically E-cadherin), a type of intercellular binding protein. Since all of the cells of the neural plate are expressing this same type of cadherin, they are able to adhere to each other; similarly, when the cells at the peaks of the neural folds come in proximity with each other, it is this affinity for similar cadherin molecules that allows these cells to bind to each other. Thus, when the neural tube precursor cells begin expressing N-cadherin in the place of E-cadherin, the cells no longer associate, causing the neural tube to separate from the ectoderm and settle inside the embryo. [3] When the cells fail to associate in a manner that is not part of the normal course of development, severe diseases can occur.

Process Overview

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The process of folding begins when the cells in the central region of the neural plate, the medial hinge point cells, bind to the notochord beneath them. This creates a central anchoring point for the process of folding to occur, and subsequently creates the neural groove. As the neural folds continue to extend, dorsolateral hinge points (DLHP) form, allowing them to conform into a tube-like structure. When the peaks of the folds (the neural crest region) touch, they merge and involute, creating the neural tube beneath the newly formed epidermal layer.[7]

Mechanism

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Cross section through the embryonic disc showing the fold.

The molecular mechanism behind this process lies in the modulation of bone morphogenic proteins. Bone morphogenic proteins (BMPs) are a wide family of proteins that perform many functions throughout the growing embryo, including stimulating the growth of cartilage and bone. In order to allow for the growth of precursor neural tissues, as opposed to precursor bone or cartilage tissues, BMP expression is decreased in the neural plate, specifically along the medial line, where the neural groove will soon form. The proteins produced from the genes Noggin and Chordin inhibit these BMPs, and subsequently allow neural commitment genes, like Sox, to be expressed. These genes encode transcription factors, which alter the genomic expression of these cells, furthering them along the path of neural cell commitment.[8] This process of BMP inhibition allows for the anchoring of the medial hinge point cells, providing the neural folds with the foundation necessary for folding and closure to occur. Noggin and Chordin have other roles in the neurulation process, including stimulating the neural crest cells to emigrate from the newly formed neural tube.[9] [10] The Sonic hedgehog gene also plays a role in attenuating BMP expression, forming the medial hinge point while inhibiting the formation of the dorsolateral hinge points, and in ensuring the proper closure of the neural folds.[11] The prechordal plate, notochord, and non-neural ectoderm are believed to be important inducer tissues which release these chemical signals, in order to trigger neural plate folding.[8]

The final adhesion of the converging neural folds is due to several different types of intercellular binding proteins. Cadherins and their CAM receptor molecules, for example, are present in two types in the neural precursor tissue: E-cadherin keeps the cells of the neural plate and surrounding ectoderm adhered to each other, while N-cadherin does the same for the cells of the neural fold. Only cells expressing the same kind of cadherin can bind to each other; since the peaks of the neural folds both express N-cadherin, they are able to merge into a continuous sheet of cells. Likewise, it is this diminished affinity between cells expressing different types of cadherin that allows the neural tube precursor cells to separate from the ectoderm, forming the neural tube on the interior of the embryo and the true epidermis on the exterior.[3] Another set of molecules involved with the merging of the neural folds are the ephrin molecules and their Eph receptors, which adhere in a similar manner to the cadherin molecules discussed above.[8]

Derivative Structures

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The merging of the neural folds gives rise to the neural tube, the precursor to the central nervous system, to neural crest cells, which give rise to a variety of diversemesenchymal cells, and to the true epidermal layer.[3] The neural fold is an extremely important structure in that this mechanism is needed in order to produce these diverse kinds of cells in the right places.

Diseases

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There are many potential diseases that can arise from the improper adhesion or merging of the neural folds. If the posterior neuropore fails to close, a condition called spina bifida can occur, in which the bottom of the spinal cord remains exposed. Often this condition can be detected during prenatal examinations and be treated before birth, though in more severe cases the individual may cope with the condition for the rest of his or her life[12]. Depending on the severity and the affected area, individuals can experience a variety of symptoms, including a varying motor function and mobility, bladder control, and/or sexual function[13].

If the failure is instead in the anterior neuropore, anencephaly occurs. In this fatal condition, the brain tissue is directly exposed to the amniotic fluid, and is subsequently degraded.[14] If the entire neural tube fails to close, the condition is referred to as craniorachischisis.

See Also

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Neurulation
Neural plate
Developmental biology

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YouTube Video of Embryonic Chick Neurulation
Anatomy of the Human Body's The Neural Tube and Groove by Henry Gray

References

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  1. ^ Colas, Jean-Fran�ois; Schoenwolf, Gary C. (1). "Towards a cellular and molecular understanding of neurulation". Developmental Dynamics. 221 (2): 117–145. doi:10.1002/dvdy.1144. PMID 11376482. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |month= ignored (help); replacement character in |first1= at position 10 (help)
  2. ^ Yamaguchi, Y (15). "How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals". Cellular and Molecular Life Sciences : CMLS: 1–16. PMID 23242429. {{cite journal}}: Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  3. ^ a b c d e Gilbert, Scott F. (2010). Developmental biology (9th ed.). Sunderland, Mass.: Sinauer Associates. ISBN 978-0878933846.
  4. ^ Lawson, A.; Anderson, H.; Schoenwolf, G. C. (2001 Feb 1). "Cellular mechanisms of neural fold formation and morphogenesis in the chick embryo". The Anatomical Record. 262 (2): 153–68. doi:10.1002/1097-0185(20010201)262:2<153::AID-AR1021>3.0.CO;2-W. PMID 11169910. {{cite journal}}: Check date values in: |date= (help)
  5. ^ "File:Embryonic Development CNS.gif". Wikimedia Commons. Retrieved 1 April 2013.
  6. ^ Ferreira, M. C.; Hilfer, S. R. (1993 Oct). "Calcium regulation of neural fold formation: visualization of the actin cytoskeleton in living chick embryos". Developmental Biology. 159 (2): 427–40. doi:10.1006/dbio.1993.1253. PMID 8405669. {{cite journal}}: Check date values in: |date= (help)
  7. ^ Rocky S. Tuan, Cecilia W. Lo, ed. (2000). "15". Developmental biology protocols, Volume 136. Humama. pp. 125–134. ISBN 9781592590650. Retrieved 1 April 2013.
  8. ^ a b c Khong, Hrsg. Jean W. Keeling; Hrsg. T. Yee (2007). Fetal and Neonatal Pathology (4. ed.). Goldaming: Springer London. pp. 702–704. ISBN 978-1846285240.{{cite book}}: CS1 maint: multiple names: authors list (link)
  9. ^ Anderson, R. M.; Stottmann, R. W.; Choi, M.; Klingensmith, J. (2006). "Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival". Developmental Dynamics. 235 (9): 2507–20. doi:10.1002/dvdy.20891. PMC 6626635. PMID 16894609. Retrieved 1 April 2013. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
  10. ^ Stottmann, R. W.; Berrong, M.; Matta, K.; Choi, M.; Klingensmith, J. (15). "The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms". Developmental Biology. 295 (2): 647–663. doi:10.1016/j.ydbio.2006.03.051. PMC 3001110. PMID PMC3001110. {{cite journal}}: Check |pmid= value (help); Check date values in: |date= and |year= / |date= mismatch (help); Unknown parameter |month= ignored (help)
  11. ^ Kirillova, I.; Novikova, I.; Augé, J.; Audollent, S.; Esnault, D.; Encha-Razavi, F.; Lazjuk, G.; Attié-Bitach, T.; Vekemans, M. (2000). "Expression of the sonic hedgehog gene in human embryos with neural tube defects". Teratology. 61 (5): 347–54. doi:10.1002/(SICI)1096-9926(200005)61:5<347::AID-TERA6>3.0.CO;2-#. PMID 10777830. Retrieved 1 April 2013. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
  12. ^ name="Kids Health" group=Nemours>Spina Bifida http://kidshealth.org/parent/system/ill/spina_bifida.html#. Retrieved 1 April 2013. {{cite web}}: Missing or empty |title= (help)
  13. ^ name="Spina Bifida Association">"SB and the Spine". Learn about Spina Bifida. Retrieved 1 April 2013.
  14. ^ group="Swiss Virtual Campus""7.2: The trilaminar germ disk (3rd week)". Human Embryology: Embryogenesis. Retrieved 22 March 2013.

Category:Embryology of nervous system