User:Louisajb/UCL-1530
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![]() | This article may be confusing or unclear to readers. (May 2011) |
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3D model (JSmol)
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Properties | |
C43H48N42+ | |
Molar mass | 620.9 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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UCL-1530 is a bis-quinolinium cyclophane analogue of dequalinium. It has been investigated for its ability to block the Ca2+-activated K+ (SKCa) channels in the sympathetic neurones of rats and guinea pig hepatocytes.[1][2]
References
[edit]- ^ Dunn, P.M.; Benton, D.C.H.; Rosa, J. Campos; Ganellin, C.R.; Jenkinson, D.H. (1996). "Discrimination between subtypes of apamin-sensitive Ca2+- activated K+ channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530". British Journal of Pharmacology. 117 (1): 35–42. doi:10.1111/j.1476-5381.1996.tb15151.x. PMC 1909372. PMID 8825340.
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: CS1 maint: PMC format (link) - ^ Campos Rosa, Joaquin; Galanakis, Dimitrios; Piergentili, Alessandro; Bhandari, Kalpana; Ganellin, C. Robin; Dunn, Philip M.; Jenkinson, Donald H. (2000). "Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes: Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel". Journal of Medicinal Chemistry. 43 (3): 420–431. doi:10.1021/jm9902537. PMID 10669569.