User:Manudouz/sandbox/Nonsense mRNA

Nonsense mRNA is a messenger RNA bearing one or more mutations that result in a premature stop codon and yield polypeptides with an amino acid sequence shorter than the wild-type or naturally occurring polypeptide.

Nonsense mRNA molecules are created when template DNA strands or the mRNA strands themselves undergo a nonsense mutation in which a protein coding sequence is mutated and a truncated amino acid sequence is coded for.

Nonsense mRNA transcripts are removed by nonsense-mediated mRNA decay.^[1]

References[edit]

^ Muhlemann, O; Eberle, A; Stalder, L; Zamudioorozco, R (2008-09-01). "Recognition and elimination of nonsense mRNA". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779 (9): 538–549. doi:10.1016/j.bbagrm.2008.06.012.

[1] Muhlemann, O; Eberle, A; Stalder, L; Zamudioorozco, R (2008-09-01). "Recognition and elimination of nonsense mRNA". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779 (9): 538–549. doi:10.1016/j.bbagrm.2008.06.012.

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