User:Md Hanif Tahsin

Haemophilia: Hemophilia is a group of hereditary genetic disorder that impir the body's ability to control blood clotting or coagulation.

Classification: 1. Hemophilia A due to factor VIII deficiency. 2. Hemophilia B due to factor XI deficiency.

Clinical feature: 1. Spem contttineous bleeding. 2. Ecmosis. 3. Pertu. 4. Bursising. 5. Haematoma. 6. Anaemia-fategue. 7. Epitexiea. 8. Vomiting. 9. Haematuria. 10. Haemothrosis (Blood joint + cavity)

D/D: 1. Von willebrands disease. 2. Vitamin K deficiency. 3. Disorder of fibrinogen/ fibrinolytic production. 4. Platelet disorder. 5. Blood vessel disorder. 6. Disseminated intravascular coagulation (DIC). 7. Hepatic disorder. 8. Causing disorder.

Lab. Diagnosis:

√ CBC:         1. Hb% - Reduced.         2. ESR - Increased.

√ PDF:         1. RBC- N/N ( Normocytic Normochronic ).         2. WBC - Normal.         3. Platelet- Normal.

√ Special Test:          1. Tourniquet Test - Usually Negative.          2. Bleeding time - Normal.          3. Cloting time - Prolonged of Decreased.          4. APTT- Decreased.          5. VWP- Normal.

Confirmatory Test :        1. Factor VIII: Reduced in Hemophilia A.        2. Factor XI: Reduced in Hemophilia B.

       √ VII: Due to Neophelia