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Center for Regenerative Therapies Dresden (CRTD)
Exterior view of the Center for Regenerative Therapies Dresden
TypeResearch Institute
Established2006
Location
Dresden, Germany
AffiliationsCenter for Molecular and Cellular Bioengineering (CMCB), TUD Dresden University of Technology
Websitehttps://tud.de/crtd

The Center for Regenerative Therapies Dresden (CRTD) is a biomedical research center located in Dresden, Germany[1]. It is part of the scientific unit Center for Molecular and Cellular Bioengineering (CMCB) of the TUD Dresden University of Technology.[2] The research at the CRTD concentrates on the principles of cell and tissue regeneration[1][2]. By gaining a deeper understanding of regenerative processes, the CRTD researchers intend to establish a basis for new diagnostics and therapies for human diseases - Therefore, the connection between basic research and clinical practice plays an important role at the CRTD[1].

Location

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CRTD is located in Saxony
CRTD
CRTD
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Location of the CRTD in Dresden.

The CRTD building is located in Dresden-Johannstadt in the vicinity of the Biotechnology Center (BIOTEC), the B CUBE - Center for Molecular Bioengineering [de], and the University Hospital Carl Gustav Carus Dresden [de][3].

History

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The CRTD was founded in 2006 as the first German Research Foundation (DFG) Research Center in eastern Germany and was awarded the status of Cluster of Excellence [3]. The funding as a DFG Cluster of Excellence ran from 2006 to 2017[4][5][6].

Construction of CRTD building was approved in July 2007[7]. The foundation stone was laid on August 21, 2009[8]. The building designed by Gunter Henn [de] was opened in October 2011[8]. It is located next to the University Hospital Carl Gustav Carus Dresden and the BioInnovationsZentrum[3].

In 2016, the CRTD together with the BIOTEC and the B CUBE - Center for Molecular Bioengineering [de] TU Dresden became part of the Center for Molecular and Cellular Bioengineering (CMCB) - a newly founded central scientific unit of the TU Dresden[9]. In 2019, the TU Dresden together with the Free State of Saxony took over the CRTD funding. It is now co-funded by the TU Dresden and the Faculty of Medicine Carl Gustav Carus[5].

Since the CRTD was founded, the research group leaders have acquired well-known funding formats such as Alexander von Humboldt Professorships[10][11], ERC Starting Grants[12], ERC Advanced Grants[13], and Freigeist Fellowships[14].

Research

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The CRTD hosts more than 20 research groups. Many of its groups are co-affiliated with other institutes in Dresden or Saxony: the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Max Planck Institute for Physics of Complex Systems (MPI-PKS), the German Center for Neurodegenerative Diseases (DZNE), the Deutsches Zentrum für Diabetesforschung (DZD/ PliD) [de], the Leibniz Institute for Polymer Research (IPF), and the University Hospital Carl Gustav Carus Dresden [de] among others.

The research at the CRTD focuses on a fundamental understanding of stem cell biology and tissue regeneration[1]. This understanding can help develop new models for human diseases as well as novel diagnostics and therapies[15].

The mission the CRTD's research groups are following is to discover principles of cell and tissue regeneration, and to leverage these principles for recognition, treatment, and reversal of diseases[16][17]. Thus, the link of basic research to the clinic plays an important role at the CRTD[17].

The CRTD research groups focus on four different research areas:

  • Hematology and Immunology - regulation of the immune system with focus on the formation of blood and immune cells. The emphasis here lies on the development of therapies for immune diseases[15][18]
  • Diabetes – investigation of how the destruction of β-cells by immune cells can be prevented and how β-cells can be used for therapies[16]
  • Neurodegenerative diseases - the mechanisms of proliferation and differentiation of brain stem cells[19][20]
  • Bone and tissue regeneration – with a goal of discovering the mechanisms of regeneration in the musculoskeletal system as well as understanding the interactions with immune and cancer cells[21]

The CRTD hosts two Alexander von Humboldt Professors: Prof. Catherina Becker and Prof. Michael Sieweke [de][10][11].

Education/Teaching

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As part of the Center for Molecular and Cellular Bioengineering (CMCB), a central scientific unit of the TU Dresden, the CRTD is involved in teaching in the Bachelor program Molecular Biology and Biotechnology as well as in the Master’s programs offered by the CMCB: Regenerative Biology and Medicine[22] as well as Molecular Bioengineering[23] and Physics of Life (formerly Nanobiophysics).[24]

It is also possible to complete a PhD at the CRTD, either in the Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) or as Bioscience PhD Student (BiPS).

Furthermore, the CRTD offers positions for volunteers in the context of the “Freiwilliges Soziales Jahr” (voluntary social year) in cooperation with the German Red Cross of Saxony[25].

Facilities

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The CRTD uses and contributes to the Technology Platform of the Center for Molecular and Cellular Bioengineering (CMCB) which offers facilities and services in the field of Life Science to all scientists at the TU Dresden and cooperating institutes[1][2].

Cooperations & Partners

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The CRTD cooperates, and it's research groups are affiliated with a variety of partner organizations, including the University Hospital Carl Gustav Carus Dresden [de][26], the Max Planck Institute of Molecular Cell Biology and Genetics[27], the Leibniz Institute for Polymer Research, and the German Center for Neurodegenerative Diseases (DZNE)[20][28]. In addition, there are also collaborations with industry. For instance, new areas of application and production processes for personalized gene and cell therapeutics, so-called "living drugs", are to be developed together with various industrial partners within the framework of the BMBF future cluster "SaxoCell"[29].

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References

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  1. ^ a b c d e "CRTD – Zentrum für Regenerative Therapien TU Dresden – Forschungseinrichtungen Dresdens Teil 2". So lebt Dresden (in German). Retrieved 22 May 2023.
  2. ^ a b c "LIFE SCIENCES!- Research & Development". Saxony Trade & Invest. Retrieved 2 June 2023.
  3. ^ a b c "New DFG Research Center at TU Dresden". bildungsklick (in German). Retrieved 18 April 2023.
  4. ^ "CRTD - Center for Regenerative Therapies TU Dresden". Dresden (in German). Retrieved 18 April 2023.
  5. ^ a b "Excellence Initiative at a Glance" (PDF). DFG. p. 80. Retrieved 18 April 2023.
  6. ^ "DFG - Annual Report 2017" (PDF). DFG (in German). Retrieved 18 April 2023.
  7. ^ "CRTD Lab Building" (PDF). State enterprise for real estate and construction management Saxony (in German). Retrieved 18 April 2023.
  8. ^ a b "Opening of Research Center for Regenerative Therapies (CRTD) in Dresden". KREBS + KIEFER. Retrieved 18 April 2023.
  9. ^ "Time for Changes". BmBF (in German). Retrieved 18 April 2023.
  10. ^ a b "Sachsen bleibt attraktiv für internationale Spitzenforscherinnen und -forscher". Sachsen (in German). Retrieved 23 May 2023.
  11. ^ a b "Michael Sieweke erforscht in Dresden die Reparaturkräfte von Makrophagen". Dresdner Neueste Nachrichten (in German). Retrieved 23 May 2023.
  12. ^ "Customized programming of human stem cells". EurekAlert!. Retrieved 23 May 2023.
  13. ^ "2,5 Millionen Euro für Hirnheil-Forschung in Dresden". Oiger (in German). Retrieved 23 May 2023.
  14. ^ "Ausgezeichnete Organe aus dem Drucker". DISY (in German). Retrieved 23 May 2023.
  15. ^ a b "Dresdner Forscher züchten Fresszellen gegen Krebs". Sächsische Zeitung (in German). Retrieved 24 May 2023.
  16. ^ a b "Zebrafische reparieren ihr Herz – und vielleicht auch unseres". mdr (in German). Retrieved 24 May 2023.
  17. ^ a b "Dresdner Regenerationsforscher reparieren Gedächtnisprobleme bei Mäusen". Dresdner Neueste Nachrichten (in German). Retrieved 24 May 2023.
  18. ^ "Wie der Darmkrebs trickst". Sächsische Zeitung (in German). Retrieved 24 May 2023.
  19. ^ "PRO RETINA Ruderchallenge für Forschungsprojekt der TU Dresden". AUGENSPIEGEL (in German). Retrieved 24 May 2023.
  20. ^ a b "Wie helfen Zebrafische gegen Alzheimer?". mdr (in German). Retrieved 24 May 2023.
  21. ^ "Unsere Leber ist nie älter als drei Jahre". mdr (in German). Retrieved 24 May 2023.
  22. ^ "Regenerative Biology and Medicine". German Academic Exchange Service (in German). Retrieved 28 May 2023.
  23. ^ "Molecular Bioengineering". German Academic Exchange Service (in German). Retrieved 28 May 2023.
  24. ^ "Physics of Life". German Academic Exchange Service (in German). Retrieved 28 May 2023.
  25. ^ "Einsatzfeld Wissenschaft im Freiwilligendienst". Engagiert-dabei – Freiwillingendienste in Sachsen (in German). Retrieved 24 May 2023.
  26. ^ "Molche auf dem Neumarkt". Sächsische Zeitung (in German). Retrieved 26 May 2023.
  27. ^ "Forschungskooperationen im Bereich Biotechnologie / Life Sciences". Dresden (in German). Retrieved 26 May 2023.
  28. ^ "Helmholtz-Gemeinschaft". Dresden (in German). Retrieved 26 May 2023.
  29. ^ "Future Cluster SaxoCell". CLUSTERS 4 FUTURE - Bundesministerium für Bildung und Forschung (in German). Retrieved 20 April 2023.
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