Btbd12^{tm1a(EUCOMM)Wtsi}

Mutant Embryonic Stem Cells

Program

EUCOMM

Floxed Exon(s)

Exon 3 of 15 (Transcript ENSMUST0000040790). Ablatation of the floxed exon causes a frameshift mutation.

Available ES Cells (Sanger)

ES Cell Clones used for Phenotyping

ES Cell Name	ES Cell Strain	ES Cell Line
EPD0027_2_A08	C57Bl/6N	JM8.N4

Adult Expression

Strong expression observed in adult brain and male reproductive organs Sample expression dataSample expression data

Age	Profile Available	Detail
Adult	Yes	Spinal Cord, Peripheral nervous system, Nasal epithelium, Cartilage, Trachea, Kidney

Genetic Background	C57BL/6NTac/Den;C57BL/6-Tyr;C57BL/6N
Genotyping Information	Click here for genotyping primers and conditions ...
Register Interest Through	EMMA

Pipeline	Link to pipeline
Headline Observations	Male and female homozygotes show reduced viability and are infertile. Female homs show decreased body weight and decreased nose-to-tail length.
Reduced nose-tail length in females, reduced body weight in females