User:Minyi Ruan/sandbox/Conflict procedure
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Conflict procedure[edit]
It is a procedure to increase/build anxiety on rats in order to do experiment on drug test for antidepressant. To investigate the effects of chronic treatment with a variety of antidepressants in rats subjected to an operant paradigm of conflict behavior. The aim of the study was to reveal possible anxiolytic like effects of antidepressants on chronic administration in rats subject to a conflict procedure during which lever pressing for food was suppressed by a conditioned signal for punishment and contingent electric foot shocks.[1]
Measure the changes in punished and unpunished periods. After a operant sessions of 5 days a week for rats training, rats reach to the fixed ratio 8(FR8) of the schedule of food reinforcement.
Punished periods- scrambled electric foot shocks according to a random ratio 50%.
Unpunished periods- signaled by the illumination of the right stimulus light as during the initial training.
Rats receives different drugs injections daily.
This study failed to exert anxiolytic like effects in an operant conflict procedure in rats. The study also suggest that operant conflict procedures in rats are not suitable to model human anxiety sensitive to antidepressant treatments.
Note: There is only a brief definition for the term from the previous editor. The article does not cite any references or sources. I also see the editor "punished/ unpunished responding" on the page. This two terms also from the research article that I found on PSYINFO. I will use this research article to cite as references to improve this article.
Planning to edit[edit]
Conflict Procedure refers to an experimental procedure that use to increase/ build anxiety on rats in order to do experiment on drug test for antidepressants, and to study the chronic treatment effect on difference antidepressants.
Study Some researchers from France have conducted an experiment on "Effects of Chronic Antidepressants in an Operant Conflict Procedure of Anxiety in the rat (1998)", "the aim of their study was to reveal possible anxiolytic like effects of antidepressants on chronic treatment. Rats were subjected to a conflict procedure during which lever pressing for food was suppressed by a conditioned signal for punishment and contingent electric foot shocks."[2] In order to operate the experiment, researchers build anxiety by electrical shocks on rats gradually through a training in serval week. This process was what researchers called Conflict Procedure.
- ^ Beaufour, C. C., Ballon, N., Le Bihan, C., Hamon, M., & Thiébot, M. (1999). Effects of chronic antidepressants in an operant conflict procedure of anxiety in the rat. Pharmacology, Biochemistry And Behavior, 62(4), 591-599. doi:10.1016/S0091-3057(98)00180-4
- ^ Beaufour, C. C., Ballon, N., Le Bihan, C., Hamon, M., & Thiébot, M. (1999). Effects of chronic antidepressants in an operant conflict procedure of anxiety in the rat. Pharmacology, Biochemistry And Behavior, 62(4), 591-599. doi:10.1016/S0091-3057(98)00180-4