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User:Mr. Ibrahem/Benzonatate

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Mr. Ibrahem/Benzonatate
Clinical data
Trade namesTessalon, Zonatuss, others
AHFS/Drugs.comMonograph
MedlinePlusa682640
License data
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Elimination half-life3-8 hours
Identifiers
  • 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-(butylamino)benzoate
Chemical and physical data
FormulaC30H53NO11
Molar mass603.750 g·mol−1
3D model (JSmol)
  • O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)c1ccc(NCCCC)cc1
  • InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3 checkY
  • Key:MAFMQEKGGFWBAB-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benzonatate, sold under the brand name Tessalon among others, is a medication used to try to help with the symptoms of cough and hiccups.[1][2] It is taken by mouth.[1] Use is not recommended in those under the age of ten.[5] Effects generally begin within 20 minutes and last up to eight hours.[1][6]

Side effects include sleepiness, dizziness, headache, upset stomach, skin rash, hallucinations, and allergic reactions.[1] Excessive doses may cause seizures, irregular heartbeat, and death.[5] Chewing or sucking on the capsule can lead to laryngospasm, bronchospasm, and circulatory collapse.[1] It is unclear if use in pregnancy or breastfeeding is safe.[7] It works by numbing stretch receptors in the lungs and suppressing the cough reflex in the brain.[1]

Benzonatate was approved for medical use in the United States in 1958.[1] It is available as a generic medication.[5] In the United States the wholesale cost of is about US$0.12 per 100 mg dose.[8] It is not available in many countries.[9] In 2017, it was the 148th most commonly prescribed medication in the United States, with more than four million prescriptions.[10][11]

References[edit]

  1. ^ a b c d e f g h i "Benzonatate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2021. Retrieved 23 March 2019.
  2. ^ a b Becker, DE (2010). "Nausea, vomiting, and hiccups: a review of mechanisms and treatment". Anesthesia Progress. 57 (4): 150–6, quiz 157. doi:10.2344/0003-3006-57.4.150. PMC 3006663. PMID 21174569.
  3. ^ "Benzonatate Use During Pregnancy". Drugs.com. 10 October 2019. Archived from the original on 8 November 2021. Retrieved 20 February 2020.
  4. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 3 March 2016. Retrieved 9 September 2020.
  5. ^ a b c "Drugs for cough". The Medical Letter on Drugs and Therapeutics. 60 (1562): 206–208. 17 December 2018. PMID 30625123.
  6. ^ "Tessalon - benzonatate capsule". DailyMed. 20 November 2019. Archived from the original on 7 November 2021. Retrieved 21 April 2020.
  7. ^ "Benzonatate Use During Pregnancy". Drugs.com. 10 October 2019. Archived from the original on 8 November 2021. Retrieved 20 February 2020.
  8. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  9. ^ Walsh, T. Declan; Caraceni, Augusto T.; Fainsinger, Robin; Foley, Kathleen M.; Glare, Paul; Goh, Cynthia; Lloyd-Williams, Mari; Olarte, Juan Nunez; Radbruch, Lukas (2008). Palliative Medicine E-Book. Elsevier Health Sciences. p. 751. ISBN 9781437721942. Archived from the original on 28 August 2021. Retrieved 9 May 2020.
  10. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  11. ^ "Benzonatate - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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