User:Mr. Ibrahem/Bexarotene
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| Clinical data | |
|---|---|
| Trade names | Targretin, others |
| AHFS/Drugs.com | Systemic: Monograph Topical: Monograph |
| MedlinePlus | a608006 |
| License data |
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| Routes of administration | By mouth, topical |
| Drug class | Retinoid[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | >99% |
| Metabolism | Liver (CYP3A4-mediated) |
| Elimination half-life | 7 hours |
| Excretion | Parent drug and metabolites are eliminated primarily through the hepatobiliary system. Less than 1% is excreted in the urine unchanged. |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C24H28O2 |
| Molar mass | 348.486 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Bexarotene, sold under the brand Targretin among others, is a medication use to treat cutaneous T cell lymphoma (CTCL).[1] It is used by mouth for advanced disease and applied to the skin for early disease.[1][3] It is used when other treatments have failed.[1][3]
Common side effects by mouth include high cholesterol, headaches, low thyroid, low white blood cells, rash, nausea, infection, dry skin, and peripheral swelling.[2] Common side effects when applied to the skin include rash and itchiness.[3] Other side effects may include liver problems, pancreatitis, and sunburns.[2] Use in pregnancy may harm the baby.[2] It is a retinoid.[1] How it works is unclear.[1]
Bexarotene was approved in the United States in 1999 and Europe in 2001.[2][1] It is available as a generic medication.[4] In the United Kingdom 100 pills of 75 mg costs the NHS about £940 as of 2021.[5] This amount in the United States is about 2,050 USD.[4]
References[edit]
- ^ a b c d e f g h i "Targretin". Archived from the original on 22 June 2021. Retrieved 10 January 2022.
- ^ a b c d e "DailyMed - BEXAROTENE capsule". dailymed.nlm.nih.gov. Archived from the original on 1 March 2021. Retrieved 10 January 2022.
- ^ a b c d "Bexarotene (Topical) Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 10 January 2022.
- ^ a b "Bexarotene Prices and Bexarotene Coupons - GoodRx". GoodRx. Retrieved 10 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 982. ISBN 978-0857114105.