User:Mr. Ibrahem/Cilostazol
Clinical data | |
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Pronunciation | /sɪˈlɒstəzɒl/ sil-OS-tə-zol |
Trade names | Pletal |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601038 |
License data |
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Routes of administration | By mouth (tablets) |
Drug class | Phosphodiesterase 3 inhibitor[1] |
Legal status | |
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Pharmacokinetic data | |
Protein binding | 95–98% |
Metabolism | Liver (CYP3A4- and CYP2C19-mediated) |
Elimination half-life | 11–13 hours |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C20H27N5O2 |
Molar mass | 369.469 g·mol−1 |
3D model (JSmol) | |
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Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.[1] If no improvement is seen after 3 months, stopping the medication is reasonable.[3] It may also be used to prevent stroke.[1] It is taken by mouth.[1]
Common side effects include headache, diarrhea, dizziness, and cough.[1] Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.[1] Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.[1]
Cilostazol was approved for medical use in the United States in 1999.[1] It is available as a generic medication.[3] A month supply in the United Kingdom costs the NHS about 5 £ as of 2019.[3] In the United States the wholesale cost of this amount is about US$6.20.[4] In 2017, it was the 301st most commonly prescribed medication in the United States, with more than one million prescriptions.[5]
References[edit]
- ^ a b c d e f g h i j "Cilostazol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 9 September 2020.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 231–232. ISBN 9780857113382.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^ "Cilostazol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.