User:Mr. Ibrahem/Crofelemer
 | |
| Clinical data | |
|---|---|
| Pronunciation | kroe fel' e mer[1] |
| Trade names | Mytesi, Fulyzaq, others |
| Other names | SP-303 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a613016 |
| License data |
|
| Routes of administration | By mouth (tablets) |
| Drug class | Botanical[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Little or no absorption from the gut |
| Chemical and physical data | |
| Formula | (C15O6,7H12)n |
| Molar mass | 860–9100 g·mol−1 |
Crofelemer, sold under the brand name Mytesi, is a medication used to treat diarrhea in people on treatment for HIV.[2] It should not be used for cases due to infection.[1] It is taken by mouth.[2]
Side effects are generally mild.[1] They may include intestinal gas, nausea, constipation, and cough.[1] Safety in pregnancy is unclear.[3] It is believed to work by blocking cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels in the intestines.[1]
Crofelemer was approved for medical use in the United States in 2012.[2] In the United States it costs about 2,400 USD per month as of 2022.[4] It is made from the sap of the South American plant Croton lechleri.[1]
References[edit]
- ^ a b c d e f g h "Crofelemer". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 May 2021. Retrieved 7 January 2022.
- ^ a b c d "DailyMed - MYTESI- crofelemer tablet, coated". dailymed.nlm.nih.gov. Archived from the original on 14 April 2021. Retrieved 7 January 2022.
- ^ "Crofelemer Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 7 January 2022.
- ^ "Mytesi Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 7 January 2022.