User:Mr. Ibrahem/Felodipine

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Mr. Ibrahem/Felodipine
Clinical data
Trade namesPlendil
AHFS/Drugs.comMonograph
MedlinePlusa692016
Routes of
administration		By mouth
Drug classCalcium channel blocker[1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability15%
MetabolismLiver
Onset of action2.5–5 hours
Elimination half-life25 hours[2]
ExcretionKidney
Identifiers
  • (RS)-3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Chemical and physical data
FormulaC18H19Cl2NO4
Molar mass384.25 g·mol−1
3D model (JSmol)
  • O=C(OCC)\C1=C(\N/C(=C(/C(=O)OC)C1c2cccc(Cl)c2Cl)C)C
  • InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 checkY
  • Key:RZTAMFZIAATZDJ-UHFFFAOYSA-N checkY
  (verify)

Felodipine, sold under the brand name Plendil among others, is a medication is used to treat high blood pressure and heart related chest pain (angina).[1][3] It is one of several first line options.[1] It is taken by mouth.[1]

Common side effects include swelling, headache, and flushing.[1] Other side effects may include syncope and low blood pressure.[1] There are concerns regarding negative effects if used during pregnancy.[5] It is a calcium channel blocker of the dihydropyridine type.[1]

Felodipine was patented in 1978 and approved for medical use in 1988.[6] It is available as a generic medication.[3] In the United Kingdom 4 weeks of 5 mg per day costs about £4 as of 2021.[3] This amount is about 11 USD in the United States.[7] It is also available in combination with ramipril.[3]

References[edit]

  1. ^ a b c d e f g h i "Felodipine Monograph for Professionals". Drugs.com. Archived from the original on 15 August 2020. Retrieved 10 December 2021.
  2. ^ "Felopidine UK label". UK Electronic Medicines Compendium. 15 September 2015. Archived from the original on 16 August 2019. Retrieved 9 March 2021.
  3. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 174. ISBN 978-0857114105.
  4. ^ Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 115, 2013, pp. 887-890
  5. ^ "Felodipine (Plendil) Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 10 December 2021.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495. Archived from the original on 27 August 2021. Retrieved 9 March 2021.
  7. ^ "Felodipine ER Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 December 2021.
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