User:Mr. Ibrahem/Fludrocortisone
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| Clinical data | |
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| Trade names | Astonin, Cortineff, Florinef, Florinefe, others |
| Other names | StC-1400; 9α-Fluorohydrocortisone; 9α-Fluorocortisol; 9α-Fluoro-17α-hydroxycorticosterone; 9α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | By mouth |
| Drug class | Corticosteroid; glucocorticoid; mineralocorticoid |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | High |
| Metabolism | Liver |
| Elimination half-life | 3.5 hours |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C21H29FO5 |
| Molar mass | 380.456 g·mol−1 |
| 3D model (JSmol) | |
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Fludrocortisone, sold under the brand name Florinef, among others, is a corticosteroid used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.[1][2] In adrenal insufficiency, it is generally taken together with hydrocortisone.[2] Fludrocortisone is taken by mouth[2] and is most commonly used in its acetate form.[4]
Common side effects include high blood pressure, swelling, heart failure, and low blood potassium.[2] Other serious side effects can include low immune system function, cataracts, muscle weakness, and mood changes.[2] It is unclear if use during pregnancy is safe for the baby.[5] Fludrocortisone is mostly a mineralocorticoid; however, it also has glucocorticoid effects.[2]
Fludrocortisone was patented in 1953.[6] It is on the World Health Organization's List of Essential Medicines.[7] In the United Kingdom it costs the NHS about 1.5 pounds per month.[8] In the United States the wholesale cost of a month of medications is about $12.[9]
References
[edit]- ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 558–. ISBN 978-1-4757-2085-3. Archived from the original on 5 November 2017.
- ^ a b c d e f g h "Fludrocortisone Acetate". The American Society of Health-System Pharmacists. Archived from the original on 5 July 2017. Retrieved 8 December 2016.
- ^ Cite error: The named reference
whowas invoked but never defined (see the help page). - ^ Richard O. Day; Daniel E. Furst; Piet L.C.M. van Riel; Barry Bresnihan (30 May 2010). Antirheumatic Therapy: Actions and Outcomes. Springer Science & Business Media. pp. 21–. ISBN 978-3-7643-7726-7. Archived from the original on 5 November 2017.
- ^ "Fludrocortisone Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 24 December 2016. Retrieved 24 December 2016.
- ^ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 484. ISBN 9783527607495. Archived from the original on 2017-11-05.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 494. ISBN 9780857111562.
- ^ "NADAC as of 2016-12-21 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Archived from the original on 24 December 2016. Retrieved 24 December 2016.