User:Mr. Ibrahem/Letrozole

Mr. Ibrahem/Letrozole
Clinical data
Trade names	Femara, others
AHFS/Drugs.com	Monograph
MedlinePlus	a698004
License data	US FDA: Letrozole;
Routes of; administration	By mouth (tablets)
Drug class	Aromatase inhibitor; Antiestrogen
Legal status
Legal status	CA: Schedule VII; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	99.9%
Protein binding	60%, mainly to albumin
Metabolism	pharmacologically-inactive metabolites Bis(4-cyanophenyl)methanol and 4,4'-dicyanobenzophenone.
Elimination half-life	2 days
Excretion	Kidneys
Identifiers
	IUPAC name 4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile;
Chemical and physical data
Formula	C17H11N5
Molar mass	285.310 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc1ccc(cc1)C(c2ccc(C#N)cc2)n3ncnc3;
	InChI InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H ; Key:HPJKCIUCZWXJDR-UHFFFAOYSA-N ;
	(verify)

Letrozole, sold under the brand name Femara among others, is a medication used for breast cancer.^[3] It has also be used in female infertility to bring about ovulation.^[3] For breast cancer, it is only used after menopause.^[2] It is taken by mouth.^[3]

Common side effects include high cholesterol, hot flushes, joint pain, and swelling.^[3] Other side effects may include infertility, tiredness, and osteoporosis.^[3] Use in pregnancy may harm the baby.^[3] It is an aromatase inhibitor.^[3]

Letrozole was patented in 1986 and approved for medical use in 1996.^[4] It is available as a generic medication.^[5] In the United States 3 months of treatment costs about 20 USD as of 2021.^[5] In the United Kingdom this amount costs the NHS about £7.^[2]

References[edit]

^ ^a ^b ^c 003330 Letrozole
^ ^a ^b ^c ^d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 999. ISBN 978-0857114105.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Letrozole Monograph for Professionals". Drugs.com. Archived from the original on 10 August 2020. Retrieved 21 November 2021.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 516. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2020-09-19.
^ ^a ^b "Letrozole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 21 November 2021.

[Letrozole-1] 003330 Letrozole

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 999. ISBN 978-0857114105.

[AHFS2021-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Letrozole Monograph for Professionals". Drugs.com. Archived from the original on 10 August 2020. Retrieved 21 November 2021.

[Fis2006-4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 516. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2020-09-19.

[GX2021-5] "Letrozole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 21 November 2021.

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