User:Mr. Ibrahem/Lomustine
Clinical data | |
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Trade names | CeeNU, Gleostine, CCNU, others |
Other names | 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682207 |
Pregnancy category |
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Routes of administration | By mouth (capsules) |
Drug class | Alkylating agent[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | ~100% |
Protein binding | 50% |
Metabolism | Liver |
Metabolites | Monoxydroxylated metabolites, trans-4-hydroxy-CCNU, cis-4-hydroxy-CCNU[2] |
Elimination half-life | 16–48 hours (metabolites) |
Identifiers | |
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Chemical and physical data | |
Formula | C9H16ClN3O2 |
Molar mass | 233.70 g·mol−1 |
3D model (JSmol) | |
Melting point | 90 °C (194 °F) |
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Lomustine sold under the brand name CeeNU, is a medication used to treat brain tumors, melanoma, and Hodgkin lymphoma (HL).[1][3] In HL it is used when other treatments have not worked.[1] It is taken by mouth.[1]
Common side effects include pulmonary fibrosis, low platelets, low white blood cells, low red blood cells, nausea, kidney problems, and liver problems.[1] Other side effects may include hair loss, confusion, vision loss, and mouth inflammation.[3] It should not be used in pregnancy or breastfeeding.[3] It is an alkylating nitrosourea compound.[1]
Lomustine was approved for medical use in the United States in 1976.[1] It is available as a generic medication.[3] In the United States it costs about 1,050 USD per 100 mg pill as of 2021.[4] This amount in the United Kingdom costs the NHS about £50.[3]
References[edit]
- ^ a b c d e f g h i "Lomustine Monograph for Professionals". Drugs.com. Archived from the original on 17 August 2019. Retrieved 24 November 2021.
- ^ Lee FY, Workman P, Roberts JT, Bleehen NM (1985). "Clinical pharmacokinetics of oral CCNU (lomustine)". Cancer Chemotherapy and Pharmacology. 14 (2): 125–31. doi:10.1007/bf00434350. PMID 3971475. S2CID 29619378.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 941. ISBN 978-0857114105.
- ^ "Gleostine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 24 November 2021.