User:Mr. Ibrahem/Methylergometrine
Clinical data | |
---|---|
Trade names | Methergine, Ergotrate, others |
Other names | Methylergometrine maleate, methylergonovine,[1] methylergobasin,[1] d-lysergic acid 1-butanolamide |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601077 |
Pregnancy category |
|
Routes of administration | Injection into a muscle or vein, by mouth[2] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Metabolism | Liver |
Elimination half-life | 30–120 min |
Excretion | Mostly bile |
Identifiers | |
| |
Chemical and physical data | |
Formula | C20H25N3O2 |
Molar mass | 339.439 g·mol−1 |
3D model (JSmol) | |
Melting point | 172 °C (342 °F) |
Solubility in water | insoluble mg/mL (20 °C) |
| |
| |
(what is this?) (verify) |
Methylergometrine, sold under the brand name Methergine among others, is a medication used to treat post partum bleeding due to poor uterine contraction.[2] It is less preferred to oxytocin for this use.[1] It has also been used to check if people have angina due to coronary vasospasms.[2] It is used by injection into a muscle, by mouth, or less commonly by injection into a vein.[1][2]
Common side effects include high blood pressure, seizures, headache, nausea, and low blood pressure.[2] Other side effects may include ringing in the ears, numbness, confusion, and chest pain.[1] Caution is advised in those who have liver problems, kidney problems, or poor blood flow.[1] Safety in pregnancy or breastfeeding is unclear and thus in these situations use is not advised.[1][2] It is in the family of medicines known as oxytocics and ergot alkaloids.[2][4]
Methylergometrine is derived from ergometrine which was initially isolated from the fungus Claviceps purpurea in 1935.[5] In the United States it is available as a generic medication and costs about 68 USD for 6 tablets of 0.2 mg as of 2020.[6] In the developing world this amount costs about 0.13 USD as of 2015 while the injectable form is about 0.18 USD per dose.[7][8]
References[edit]
- ^ a b c d e f g h "METHYLERGOMETRINE injectable - Essential drugs". medicalguidelines.msf.org. Archived from the original on 29 August 2021. Retrieved 2 September 2020.
- ^ a b c d e f g "Methylergonovine Maleate Monograph for Professionals". Drugs.com. Archived from the original on 20 September 2016. Retrieved 2 September 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 December 2020. Retrieved 2 September 2020.
- ^ Clinical Pharmacology During Pregnancy. Academic Press. 2012. p. 310. ISBN 978-0-12-386008-8. Archived from the original on 2021-08-29. Retrieved 2020-09-02.
- ^ Briggs, Gerald G.; Nageotte, Michael (2009). Diseases, Complications, and Drug Therapy in Obstetrics: A Guide for Clinicians. ASHP. p. 264. ISBN 978-1-58528-337-8. Archived from the original on 2021-08-29. Retrieved 2020-09-02.
- ^ "Methergine Prices and Methergine Coupons". GoodRx. Archived from the original on 16 August 2016. Retrieved 30 October 2020.
- ^ "Single Drug Information – International Medical Products Price Guide". Archived from the original on 28 August 2021. Retrieved 30 October 2020.
- ^ "Single Drug Information – International Medical Products Price Guide". Archived from the original on 28 August 2021. Retrieved 30 October 2020.