User:Mr. Ibrahem/Obeticholic acid
Appearance
Clinical data | |
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Trade names | Ocaliva |
Other names | 6α-ethyl-chenodeoxycholic acid; INT-747 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a616033 |
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Routes of administration | By mouth |
Drug class | Modified bile acid[1] |
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Chemical and physical data | |
Formula | C26H44O4 |
Molar mass | 420.634 g·mol−1 |
3D model (JSmol) | |
Melting point | 108–110 °C (226–230 °F) [2] |
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Obeticholic acid (OCA), sold under the brand name Ocaliva, is a medication used to treat primary biliary cholangitis.[3] It is generally used in addition to ursodeoxycholic acid when this is insufficiently effective.[3] It is taken by mouth.[3]
Common side effects include itching and tiredness.[1] Other side effects may include liver problems.[3] It is a modified form of bile acid and works by attaching to farnesoid X receptors and decreasing bile production by the liver.[1]
Obeticholic acid was approved for medical use in the United States and Europe in 2016.[4][1] In the United Kingdom it costs the NHS about £2,400 per month as of 2021.[3] In the United States this amount costs about 8,000 USD.[5]
References
[edit]- ^ a b c d e f "Ocaliva". Archived from the original on 8 November 2021. Retrieved 6 November 2021.
- ^ Gioiello, Antimo; Macchiarulo, Antonio; Carotti, Andrea; Filipponi, Paolo; Costantino, Gabriele; Rizzo, Giovanni; Adorini, Luciano; Pellicciari, Roberto (April 2011). "Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine". Bioorganic & Medicinal Chemistry. 19 (8): 2650–2658. doi:10.1016/j.bmc.2011.03.004. PMID 21459580.
- ^ a b c d e f g h BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 96. ISBN 978-0857114105.
- ^ "Obeticholic Acid Monograph for Professionals". Drugs.com. Archived from the original on 16 July 2017. Retrieved 6 November 2021.
- ^ "Ocaliva Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 April 2021. Retrieved 6 November 2021.