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User:Mr. Ibrahem/Prazosin

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Mr. Ibrahem/Prazosin
Clinical data
Trade namesMinipress, Vasoflex, Lentopres, others
AHFS/Drugs.comMonograph
MedlinePlusa682245
License data
Pregnancy
category
Addiction
liability		None
Routes of
administration		By mouth
Drug classα1-blocker[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability~60%
Protein binding97%[3]
Onset of action30–90 minutes[4]
Elimination half-life2–3 hours[3]
Duration of action10–24 hours[3]
Identifiers
  • [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone
Chemical and physical data
FormulaC19H21N5O4
Molar mass383.408 g·mol−1
3D model (JSmol)
  • O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)c4occc4
  • InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) checkY
  • Key:IENZQIKPVFGBNW-UHFFFAOYSA-N checkY
  (verify)

Prazosin is a medication primarily used to treat high blood pressure, symptoms of an enlarged prostate, and posttraumatic stress disorder (PTSD).[2] It is a less preferred treatment of high blood pressure.[2] Other uses may include heart failure and Raynaud syndrome.[6] It is taken by mouth.[2]

Common side effects include dizziness, sleepiness, nausea, and heart palpitations.[2] Serious side effects may include low blood pressure with standing and depression.[2][6] Prazosin is an α1-blocker.[2] It works to decrease blood pressure by dilating blood vessels and helps with an enlarged prostate by relaxing the outflow of the bladder.[2] How it works in PTSD is not entirely clear.[2]

Prazosin was patented in 1965 and came into medical use in 1974.[7] It is available as a generic medication.[2] A month supply in the United Kingdom costs about £3.50 as of 2019.[6] In the United States, the wholesale cost of this amount is about US$20.[8] In 2017, it was the 227th most commonly prescribed medication in the United States, with more than two million prescriptions.[9][10]

References

[edit]
  1. ^ a b "Prazosin (Minipress) Use During Pregnancy". Drugs.com. 26 November 2019. Archived from the original on 21 October 2020. Retrieved 30 January 2020.
  2. ^ a b c d e f g h i j k l "Prazosin Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 April 2019. Retrieved 18 March 2019.
  3. ^ a b c "Prazosin". drugs.com. Archived from the original on 3 December 2020. Retrieved 15 March 2020.
  4. ^ Packer M, Meller J, Gorlin R, Herman MV (March 1979). "Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure". Circulation. 59 (3): 531–9. doi:10.1161/01.cir.59.3.531. PMID 761333.
  5. ^ Cite error: The named reference WHO2020DDD was invoked but never defined (see the help page).
  6. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 766. ISBN 9780857113382.
  7. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 455. ISBN 9783527607495. Archived from the original on 22 December 2019. Retrieved 28 February 2019.
  8. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  10. ^ "Prazosin Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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