User:Mr. Ibrahem/Protriptyline

Mr. Ibrahem/Protriptyline
Clinical data
Trade names	Vivactyl, others
Other names	Amimethyline; Protriptyline hydrochloride; MK-240
AHFS/Drugs.com	Monograph
MedlinePlus	a604025
Routes of; administration	By mouth
Drug class	Tricyclic antidepressant (TCA)
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	77–93%
Protein binding	92%
Metabolism	Liver
Elimination half-life	54–92 hours
Excretion	Urine: 50%; Feces: minor
Identifiers
	IUPAC name 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine;
Chemical and physical data
Formula	C19H21N
Molar mass	263.384 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3cc2c(\C=C/c1c(cccc1)C2CCCNC)cc3;
	InChI InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3 ; Key:BWPIARFWQZKAIA-UHFFFAOYSA-N ;
	(verify)

Protriptyline, sold under the brand name Vivactil among others, is a medication used to treat depression.^[1] While it has been used for obstructive sleep apnea it has not been found useful for this.^[1] It is taken by mouth.^[1]

Common side effects include anxiety, dizziness, dry mouth, fast heart rate, blurry vision, and constipation.^[1] Other side effects may include psychosis, mania, sunburns, and suicide.^[1] Safety in pregnancy and breastfeeding is unclear.^[3] It is a tricyclic antidepressant (TCA).^[1]

Protriptyline was approved for medical use in the United States in 1967.^[1] In the United States 60 tablets of 10 mg costs about 80 USD as of 2021.^[4] As of 2000 it is no longer commercially available in Australia or the United Kingdom.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Protriptyline Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 29 October 2021.
^ ^a ^b ^c ^d Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0. Archived from the original on 16 December 2019. Retrieved 14 October 2021.
^ "Protriptyline (Vivactil) Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 29 October 2021.
^ "Protriptyline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.
^ "Protriptyline". web.archive.org. NHS. 20 August 2013. Archived from the original on 20 August 2013. Retrieved 29 October 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Protriptyline Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 29 October 2021.

[LemkeWilliams2012-2] Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0. Archived from the original on 16 December 2019. Retrieved 14 October 2021.

[3] "Protriptyline (Vivactil) Use During Pregnancy". Drugs.com. Archived from the original on 24 November 2020. Retrieved 29 October 2021.

[4] "Protriptyline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.

[UK2000-5] "Protriptyline". web.archive.org. NHS. 20 August 2013. Archived from the original on 20 August 2013. Retrieved 29 October 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

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