User:Mr. Ibrahem/Prucalopride

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Mr. Ibrahem/Prucalopride
Clinical data
Trade namesPrudac, Resolor, Resotran, other
AHFS/Drugs.comMonograph
MedlinePlusa619011
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth
Drug class5-HT4 receptor agonist[1]
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Identifiers
  • 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
Chemical and physical data
FormulaC18H26ClN3O3
Molar mass367.87 g·mol−1
3D model (JSmol)
  • COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
  • InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) ☒N
  • Key:ZPMNHBXQOOVQJL-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Prucalopride, sold under the brand name Resolor among others, is a medication used to treat chronic constipation of unknown cause.[1][2] It may be used when other laxatives are not effective; though is not recommended in Scotland.[3] It is taken by mouth.[1]

Common side effects include headache, nausea, diarrhea, and abdominal pain.[1] Other side effects may include allergic reactions and suicide.[2] Safety in pregnancy is unclear.[2] It is a 5-HT4 receptor agonist which works by stimulating movement of the gut.[1]

Prucalopride was approved for medical use in Europe in 2009,[1] Canada in 2011,[4] Israel in 2014,[5] and the United States in 2018.[2] In the United Kingdom four weeks of medication costs the NHS about £60 as of 2021.[3] In the United States this amount costs about 430 USD.[6]

References[edit]

  1. ^ a b c d e f g h i "Resolor". Archived from the original on 31 January 2010. Retrieved 29 October 2021.
  2. ^ a b c d "Prucalopride Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 29 October 2021.
  3. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 64. ISBN 978-0857114105.
  4. ^ "Health Canada, Notice of Decision for Resotran". hc-sc.gc.ca. Archived from the original on 18 March 2017. Retrieved 1 May 2018.
  5. ^ "Digestive Remedies in Israel". www.euromonitor.com. Archived from the original on 13 March 2018. Retrieved 1 May 2018.
  6. ^ "Motegrity Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.
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