User:Mr. Ibrahem/Ribociclib

Mr. Ibrahem/Ribociclib
Clinical data
Trade names	Kisqali
Other names	LEE 011
AHFS/Drugs.com	Monograph
MedlinePlus	a617008
License data	US DailyMed: Ribociclib;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	Unknown
Protein binding	~70%
Metabolism	Liver (CYP3A4)
Elimination half-life	32.0 (29.7–54.7) hrs
Excretion	69% feces, 23% urine
Identifiers
	IUPAC name 7-Cyclopentyl-N,N-dimethyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;
Chemical and physical data
Formula	C23H30N8O
Molar mass	434.548 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)C(=O)c1cc2cnc(nc2n1C3CCCC3)Nc4ccc(cn4)N5CCNCC5;
	InChI InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28); Key:RHXHGRAEPCAFML-UHFFFAOYSA-N;

Ribociclib, sold under the brand name Kisqali, is a medication used to treat certain kinds of breast cancer.^[1] Specifically it is used for HR-positive, HER2-negative disease.^[1] It is taken by mouth.^[1]

Common side effects include low neutrophils, nausea, tiredness, diarrhea, hair loss, headache, rash, and cough.^[2] Other side effects may include low phosphate, QT prolongation, and liver problems.^[3]^[4] Use in pregnancy may harm the baby.^[1] It works by blocking the enzymes CDK4 and CDK6.^[3]

Ribociclib was approved for medical use in Europe and the United States in 2017.^[3]^[1] In the United States it costs about 13,800 USD per 4 weeks as of 2021.^[5] This amount in the United Kingdom costs the NHS about £2,950.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f "Ribociclib Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 17 October 2021.
^ ^a ^b "DailyMed - KISQALI- ribociclib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 4 April 2021. Retrieved 17 October 2021.
^ ^a ^b ^c "Kisqali". Archived from the original on 29 August 2021. Retrieved 17 October 2021.
^ ^a ^b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1055. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Ribociclib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f "Ribociclib Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 17 October 2021.

[PI2021-2] "DailyMed - KISQALI- ribociclib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 4 April 2021. Retrieved 17 October 2021.

[EPAR2021-3] "Kisqali". Archived from the original on 29 August 2021. Retrieved 17 October 2021.

[BNF80-4] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1055. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[5] "Ribociclib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 October 2021.

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