User:Mr. Ibrahem/Saxagliptin

Mr. Ibrahem/Saxagliptin
Clinical data
Trade names	Onglyza
Other names	Saxagliptin hydrochloride, BMS-477118
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a610003
License data	EU EMA: by INN; US FDA: Saxagliptin;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth (tablets)
Drug class	DPP-4 inhibitor
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	~75% (Tmax = 2 h)
Protein binding	negligible
Metabolism	Hepatic (CYP3A4 and CYP3A5)
Elimination half-life	2.5 h (saxagliptin), 3.1 h (main metabolite)
Excretion	22% (Bile), 75% (Urine)
Identifiers
	IUPAC name (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile;
Chemical and physical data
Formula	C18H25N3O2
Molar mass	315.417 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N1[C@H](C#N)C[C@@H]2C[C@H]12)[C@@H](N)C35CC4CC(C3)CC(O)(C4)C5;
	InChI InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1 ; Key:QGJUIPDUBHWZPV-SGTAVMJGSA-N ;
	(what is this?) (verify)

Saxagliptin, sold under the brand name Onglyza, is a medication used to treat type 2 diabetes.^[1] It is typically used either with metformin or when metformin is not tolerated.^[2] It is taken by mouth.^[1]

Common side effects include headache and urinary tract infection.^[1] Other side effects may include pancreatitis, joint pain, low blood sugar, and heart failure.^[1] While there is no evidence of harm in pregnancy, its use has not been well studied.^[3] It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, which indirectly increases insulin when required.^[1]

Saxagliptin was approved for medical use in the United States and Europe in 2009.^[4]^[1] In the United Kingdom 4 weeks of treatment costs the NHS about £32 as of 2021.^[2] This amount in the United States costs about 400 USD.^[5] It is also available in combination with other medication including metformin or dapagliflozin.^[2]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "SAXagliptin Monograph for Professionals". Drugs.com. Archived from the original on 23 April 2021. Retrieved 11 October 2021.
^ ^a ^b ^c ^d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 732. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Saxagliptin (Onglyza) Use During Pregnancy". Drugs.com. Archived from the original on 21 April 2021. Retrieved 11 October 2021.
^ "Onglyza". Archived from the original on 28 August 2021. Retrieved 11 October 2021.
^ "Saxagliptin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 October 2021. Retrieved 11 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "SAXagliptin Monograph for Professionals". Drugs.com. Archived from the original on 23 April 2021. Retrieved 11 October 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 732. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Preg2021-3] "Saxagliptin (Onglyza) Use During Pregnancy". Drugs.com. Archived from the original on 21 April 2021. Retrieved 11 October 2021.

[EPAR2021-4] "Onglyza". Archived from the original on 28 August 2021. Retrieved 11 October 2021.

[5] "Saxagliptin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 October 2021. Retrieved 11 October 2021.

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