User:Mr. Ibrahem/Shingles vaccine

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Mr. Ibrahem/Shingles vaccine
Shingles vaccines (Shingrix and Zostavax)
Vaccine description
TargetHerpes zoster, postherpetic neuralgia[1]
Vaccine typeShingrix (recombinant protein subunit)
Zostavax (attenuated)
Clinical data
Trade namesShingrix, Zostavax
Other namesZoster vaccine recombinant (RZV)
Zoster vaccine live (ZVL)
AHFS/Drugs.comShingrix Monograph
Zostavax Monograph
License data
Pregnancy
category
Routes of
administration		Shingrix (intramuscular)
Zostavax (subcutaneous)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)[3]
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
  (verify)

Shingles vaccine, also known as zoster vaccine, of which there are two types, Shingrix and Zostavax, are vaccines that reduce the risk of shingles and postherpetic neuralgia, due to reactivation of the chickenpox virus (varicella zoster virus (VZV)).[1] Shingrix appears to prevent more cases of shingles than Zostavax, although side effects are more frequent and it requires two doses.[5][6] Shingrix is approved in over 50 years old, regardless of prior chickenpox, shingles, or shingles vaccine.[1] For those with weakened immune systems, Shingrix is preferable.[7] They are given by injection.[6]

Shingrix is a recombinant subunit vaccine.[8] Zostavax is a live attenuated vaccine which basically consists of a larger-than-normal dose of chickenpox vaccine.[9][10] Unlike Shingrix, Zostavax is not suitable for people with immunosuppression or who are pregnant.[9][11] The side effects of both vaccines are generally mild to moderate and can include pain at the site of injection, tiredness, and headache.[6][12]

Shingrix was approved for medical use in the United States in 2017 while Zostavax was approved for medical use in 2006.[13] In the United States Shingrix costs 310 USD for two dose as of 2021.[14] In the United Kingdom a dose of Zostavax costs the NHS about £100.[15] As of 2020, Zostavax is no longer available in the United States.[1] As of 2023, Zostavax is being replaced by Shingrix in the UK's national immunisation program.[7]

References[edit]

  1. ^ a b c d Bonville, Cynthia; Domachowske, Joseph (2021). "33. Varicella and Shingles". In Domachowske, Joseph; Suryadevara, Manika (eds.). Vaccines: A Clinical Overview and Practical Guide. Switzerland: Springer. pp. 392–395. ISBN 978-3-030-58416-0. Archived from the original on 19 June 2022. Retrieved 17 June 2022.
  2. ^ a b "Zoster vaccine live (Zostavax) Use During Pregnancy". Drugs.com. 3 January 2020. Archived from the original on 16 May 2021. Retrieved 23 January 2020.
  3. ^ "Zostavax vaccine - Summary of Product Characteristics (SmPC)". (emc). 28 January 2019. Archived from the original on 16 May 2021. Retrieved 6 September 2020.
  4. ^ "Zoster vaccine, inactivated (Shingrix) Use During Pregnancy". Drugs.com. 12 March 2018. Archived from the original on 16 May 2021. Retrieved 23 January 2020.
  5. ^ Tricco AC, Zarin W, Cardoso R, Veroniki AA, Khan PA, Nincic V, et al. (October 2018). "Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis". BMJ. 363: k4029. doi:10.1136/bmj.k4029. PMC 6201212. PMID 30361202.
  6. ^ a b c Gagliardi AM, Andriolo BN, Torloni MR, et al. (November 2019). "Vaccines for preventing herpes zoster in older adults". The Cochrane Database of Systematic Reviews. 2019 (11). doi:10.1002/14651858.CD008858.pub4. PMC 6836378. PMID 31696946.
  7. ^ a b "28a. Shingles (herpes zoster)". Shingles (herpes zoster). UK Health Security Agency. 26 July 2023. Archived from the original on 2 June 2023. Retrieved 16 October 2023. From September 2023, Shingrix is replacing Zostavax in the routine immunisation programme.
  8. ^ "Zoster Vaccine Recombinant Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 5 August 2021.
  9. ^ a b Saguil A, Kane S, Mercado M, Lauters R (November 2017). "Herpes zoster and postherpetic neuralgia: prevention and management". American Family Physician. 96 (10): 656–663. PMID 29431387. Archived from the original on 25 April 2021. Retrieved 21 July 2021.
  10. ^ Gershon AA, Breuer J, Cohen JI, Cohrs RJ, Gershon MD, Gilden D, et al. (July 2015). "Varicella zoster virus infection". Nature Reviews. Disease Primers. 1: 15016. doi:10.1038/nrdp.2015.16. PMC 5381807. PMID 27188665.
  11. ^ "Shingles Zostavax Vaccination | What You Should Know | CDC". www.cdc.gov. 25 February 2021. Archived from the original on 17 November 2018. Retrieved 5 August 2021.
  12. ^ "Zoster Vaccine Live Monograph for Professionals". Drugs.com. Archived from the original on 7 September 2015. Retrieved 5 August 2021.
  13. ^ "Varicella and herpes zoster vaccines: WHO position paper, June 2014" (PDF). Releve epidemiologique hebdomadaire. 89 (25): 265–87. 20 June 2014. PMID 24983077. Archived (PDF) from the original on 20 September 2018. Retrieved 5 August 2021.
  14. ^ "Shingrix Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 June 2021. Retrieved 5 August 2021.
  15. ^ "14. Vaccines". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. pp. 1393–1394. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)
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