User:Mr. Ibrahem/Sufentanil

Mr. Ibrahem/Sufentanil
Clinical data
Trade names	Dsuvia, Sufenta, Zalviso, others
Other names	R30730
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US DailyMed: Sufentanil;
Routes of; administration	Intravenous therapy (IV), intramuscular injection (IM), subcutaneous injection (SQ), epidural, intrathecal
Drug class	Opioid
Legal status
Legal status	AU: S8 (Controlled drug); CA: Schedule I; DE: Anlage III (Special prescription form required); UK: Class A; US: Schedule II; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	162 minutes
Duration of action	Up to 4 hr
Identifiers
	IUPAC name N-[4-(Methoxymethyl)-1-(2-thiofuran-2-ylethyl)-4-piperidyl]-N-phenylpropanamide;
Chemical and physical data
Formula	C22H30N2O2S
Molar mass	386.55 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	97 °C (207 °F)
	SMILES O=C(N(c1ccccc1)C2(COC)CCN(CC2)CCc3sccc3)CC;
	InChI InChI=1S/C22H30N2O2S/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20/h4-10,17H,3,11-16,18H2,1-2H3 ; Key:GGCSSNBKKAUURC-UHFFFAOYSA-N ;
	(verify)

Sufentanil, sold under the brand names Sufenta among others, is an opioid medication used to treat moderate to severe pain and during anesthesia.^[1]^[2] It may be given under the tongue, by injection into a vein, or into epidural space.^[1]^[2] Effects last for up to 4 hours.^[1]

Common side effects include respiratory depression (insufficient breathing) and stiff muscles.^[1] Other side effects may include abuse, adrenal insufficiency, low blood pressure, androgen deficiency, and serotonin syndrome.^[1] It works by attaching to μ-opioid receptors in the brain.^[2]

Sufentanil was first made in 174 and approved for medical use in the United States in 1984.^[3]^[1] In the United States it costs about 50 USD for 500 ucg as of 2021.^[4] In the United States it is classified as a Schedule II controlled substance.^[1]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "SUFentanil Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 15 October 2021.
^ ^a ^b ^c ^d "Dzuveo". Archived from the original on 23 November 2020. Retrieved 15 October 2021.
^ Baheti, Dwarkadas K.; Laheri, Vandana V. (31 March 2018). Understanding Anesthetic Equipment & Procedures: A Practical Approach. JP Medical Ltd. p. 16. ISBN 978-93-5270-316-6. Archived from the original on 17 October 2021. Retrieved 15 October 2021.
^ "Sufentanil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 October 2020. Retrieved 15 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "SUFentanil Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 15 October 2021.

[EPAR2021-2] "Dzuveo". Archived from the original on 23 November 2020. Retrieved 15 October 2021.

[3] Baheti, Dwarkadas K.; Laheri, Vandana V. (31 March 2018). Understanding Anesthetic Equipment & Procedures: A Practical Approach. JP Medical Ltd. p. 16. ISBN 978-93-5270-316-6. Archived from the original on 17 October 2021. Retrieved 15 October 2021.

[4] "Sufentanil Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 October 2020. Retrieved 15 October 2021.

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