User:Mr. Ibrahem/Trifluridine

Mr. Ibrahem/Trifluridine
Clinical data
Trade names	Viroptic; Lonsurf (+tipiracil)
Other names	α,α,α-trifluorothymidine; 5-trifluromethyl-2′-deoxyuridine; FTD5-trifluoro-2′-deoxythymidine; TFT; CF3dUrd; FTD; F3TDR; F3Thd
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN;
Routes of; administration	Eye drops; tablets (+tipiracil)
Drug class	Antiviral
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Pharmacokinetic data
Bioavailability	Negligible (eye drops);; ≥57% (by mouth)
Protein binding	>96%
Metabolism	Thymidine phosphorylase
Elimination half-life	12 minutes (eye drops);; 1.4–2.1 hrs (combination with tipiracil)
Excretion	Mostly via urine
Identifiers
	IUPAC name 1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-(1H,3H)-pyrimidine-2,4-dione;
Chemical and physical data
Formula	C10H11F3N2O5
Molar mass	296.202 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)C=1C(=O)NC(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)C2)CO;
	InChI InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1 ; Key:VSQQQLOSPVPRAZ-RRKCRQDMSA-N ;
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Trifluridine, also called trifluorothymidine (TFT) is an antiviral medication used to treat herpes simplex infections of the eye.^[1] It may also be used for vaccinia infections of the eye that can occur following smallpox vaccination.^[1] It is used as an eye drop.^[1]

Common side effects include irrigation, eyelid swelling, and redness of the eyes.^[1] It is believed to work by stopping the creation of viral DNA.^[1]

Trifluridine was approved for medical use in the United States in 1980.^[1]^[2] It is available as a generic medication and is also sold under the trade name Viroptic.^[3]^[1] In the United States a 7.5 ml container costs about 74 USD.^[3] It is also a component of the anti-cancer medication trifluridine/tipiracil.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Trifluridine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.
^ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-09-20.
^ ^a ^b "Viroptic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 19 September 2021.
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Trifluridine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.

[2] Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-09-20.

[GX2021-3] "Viroptic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 19 September 2021.

[BNF80-4] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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