User:Mr. Ibrahem/Triprolidine
Clinical data | |
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Trade names | Actidil, Myidil With pseudoephedrine: Actifed |
AHFS/Drugs.com | Monograph |
Pregnancy category |
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Routes of administration | By mouth[1] |
Drug class | First generation antihistamine[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 4% oral |
Protein binding | 90% |
Metabolism | Liver (CYP2D6) |
Elimination half-life | 4–6 hours |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C19H22N2 |
Molar mass | 278.399 g·mol−1 |
3D model (JSmol) | |
Melting point | 60 °C (140 °F) |
Solubility in water | 500 mg/mL (20 °C) |
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Triprolidine, sold under the brand name Zymine among others, is a medication used to treat allergies and the symptoms of the common cold.[1] It is taken by mouth.[1] Use is not recommended in children less than 2 years old.[1]
Common side effects include sleepiness, dry mouth, nausea, dizziness, blurry vision, and urinary retention.[1] Safety in pregnancy is unclear; though use during breastfeeding appears okay.[2] Other side effects may include low blood pressure.[1] It is a first generation antihistamine.[1]
Triprolidine was patented in 1948 and came into medical use in 1953.[3] It is available as a generic medication and over the counter.[4][5] In the United States 30 ml costs less around 20 USD.[4] It may be sold together with other agents such as pseudoephedrine.[1]
References[edit]
- ^ a b c d e f g h i j k "Triprolidine Monograph for Professionals". Drugs.com. Archived from the original on 29 August 2021. Retrieved 20 September 2021.
- ^ "Triprolidine Use During Pregnancy". Drugs.com. Archived from the original on 29 August 2021. Retrieved 20 September 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495. Archived from the original on 2021-05-12. Retrieved 2020-09-20.
- ^ a b "Compare Triprolidine Prices - GoodRx". GoodRx. Retrieved 20 September 2021.
- ^ "Over-the-counter cough and cold medicines for children". GOV.UK. Archived from the original on 27 July 2019. Retrieved 20 September 2021.