Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 03:30, 16 November 2007 (UTC)
[edit]Proteins without matches (15)
[edit]Proteins with a High Potential Match (3)
[edit]Redirected Proteins (7)
[edit]Manual Inspection (Page not found) (18)
[edit]
Protein Status Grid - Date: 03:30, 16 November 2007 (UTC)
[edit]Vebose Log - Date: 03:30, 16 November 2007 (UTC)
[edit]- INFO: Beginning work on AMBP... {November 15, 2007 7:10:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:10:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AMBP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bik.
| PDB = {{PDB2|1bik}}
| Name = Alpha-1-microglobulin/bikunin precursor
| HGNCid = 453
| Symbol = AMBP
| AltSymbols =; HCP; ITI; ITIL; UTI
| OMIM = 176870
| ECnumber =
| Homologene = 1234
| MGIid = 88002
| GeneAtlas_image1 = PBB_GE_AMBP_205477_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0019855 |text = calcium channel inhibitor activity}} {{GNF_GO|id=GO:0019862 |text = IgA binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0030304 |text = trypsin inhibitor activity}} {{GNF_GO|id=GO:0030568 |text = plasmin inhibitor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046904 |text = calcium oxalate binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0042167 |text = heme catabolic process}} {{GNF_GO|id=GO:0046329 |text = negative regulation of JNK cascade}} {{GNF_GO|id=GO:0050777 |text = negative regulation of immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 259
| Hs_Ensembl = ENSG00000106927
| Hs_RefseqProtein = NP_001624
| Hs_RefseqmRNA = NM_001633
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 115862231
| Hs_GenLoc_end = 115880536
| Hs_Uniprot = P02760
| Mm_EntrezGene = 11699
| Mm_Ensembl = ENSMUSG00000028356
| Mm_RefseqmRNA = NM_007443
| Mm_RefseqProtein = NP_031469
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 62629637
| Mm_GenLoc_end = 62640516
| Mm_Uniprot = Q925W1
}}
}}
'''Alpha-1-microglobulin/bikunin precursor''', also known as '''AMBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Akerström B, Lögdberg L, Berggård T, ''et al.'' |title=alpha(1)-Microglobulin: a yellow-brown lipocalin. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 172-84 |year= 2000 |pmid= 11058759 |doi= }}
*{{cite journal | author=Kobayashi H, Suzuki M, Hirashima Y, Terao T |title=The protease inhibitor bikunin, a novel anti-metastatic agent. |journal=Biol. Chem. |volume=384 |issue= 5 |pages= 749-54 |year= 2004 |pmid= 12817471 |doi= }}
*{{cite journal | author=Ekström B, Berggård I |title=Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties. |journal=J. Biol. Chem. |volume=252 |issue= 22 |pages= 8048-57 |year= 1977 |pmid= 72071 |doi= }}
*{{cite journal | author=Salier JP, Simon D, Rouet P, ''et al.'' |title=Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. |journal=Genomics |volume=14 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1385302 |doi= }}
*{{cite journal | author=Escribano J, Lopex-Otin C, Hjerpe A, ''et al.'' |title=Location and characterization of the three carbohydrate prosthetic groups of human protein HC. |journal=FEBS Lett. |volume=266 |issue= 1-2 |pages= 167-70 |year= 1990 |pmid= 1694784 |doi= }}
*{{cite journal | author=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, ''et al.'' |title=Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene. |journal=Eur. J. Biochem. |volume=191 |issue= 1 |pages= 131-9 |year= 1990 |pmid= 1696200 |doi= }}
*{{cite journal | author=Falkenberg C, Grubb A, Akerström B |title=Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue. |journal=J. Biol. Chem. |volume=265 |issue= 27 |pages= 16150-7 |year= 1990 |pmid= 1697852 |doi= }}
*{{cite journal | author=Nazimova SV, Akulenko IV, Zaĭtseva IV, ''et al.'' |title=[Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy] |journal=Akusherstvo i ginekologiia |volume= |issue= 7 |pages= 70-2 |year= 1990 |pmid= 1700638 |doi= }}
*{{cite journal | author=Vetr H, Gebhard W |title=Structure of the human alpha 1-microglobulin-bikunin gene. |journal=Biol. Chem. Hoppe-Seyler |volume=371 |issue= 12 |pages= 1185-96 |year= 1991 |pmid= 1708673 |doi= }}
*{{cite journal | author=Escribano J, Grubb A, Calero M, Méndez E |title=The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC. |journal=J. Biol. Chem. |volume=266 |issue= 24 |pages= 15758-63 |year= 1991 |pmid= 1714898 |doi= }}
*{{cite journal | author=Enghild JJ, Salvesen G, Hefta SA, ''et al.'' |title=Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 747-51 |year= 1991 |pmid= 1898736 |doi= }}
*{{cite journal | author=Reisinger P, Hochstrasser K, Albrecht GJ, ''et al.'' |title=Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase. |journal=Biol. Chem. Hoppe-Seyler |volume=366 |issue= 5 |pages= 479-83 |year= 1985 |pmid= 2408638 |doi= }}
*{{cite journal | author=Bourguignon J, Diarra-Mehrpour M, Sesboüé R, ''et al.'' |title=Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=131 |issue= 3 |pages= 1146-53 |year= 1985 |pmid= 2413856 |doi= }}
*{{cite journal | author=Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F |title=Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 5 |pages= 1472-5 |year= 1986 |pmid= 2419908 |doi= }}
*{{cite journal | author=Traboni C, Cortese R |title=Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin). |journal=Nucleic Acids Res. |volume=14 |issue= 15 |pages= 6340 |year= 1986 |pmid= 2428011 |doi= }}
*{{cite journal | author=Kaumeyer JF, Polazzi JO, Kotick MP |title=The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC). |journal=Nucleic Acids Res. |volume=14 |issue= 20 |pages= 7839-50 |year= 1986 |pmid= 2430261 |doi= }}
*{{cite journal | author=Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, ''et al.'' |title=[Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors] |journal=Vopr. Med. Khim. |volume=35 |issue= 5 |pages= 130-2 |year= 1990 |pmid= 2482577 |doi= }}
*{{cite journal | author=Schreitmüller T, Hochstrasser K, Reisinger PW, ''et al.'' |title=cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins. |journal=Biol. Chem. Hoppe-Seyler |volume=368 |issue= 8 |pages= 963-70 |year= 1987 |pmid= 3663330 |doi= }}
*{{cite journal | author=Morii M, Travis J |title=The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein. |journal=Biol. Chem. Hoppe-Seyler |volume=366 |issue= 1 |pages= 19-21 |year= 1985 |pmid= 3890890 |doi= }}
*{{cite journal | author=Takagi T, Takagi K, Kawai T |title=Complete amino acid sequence of human alpha 1-microglobulin. |journal=Biochem. Biophys. Res. Commun. |volume=98 |issue= 4 |pages= 997-1001 |year= 1981 |pmid= 6164372 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATP2A2... {November 15, 2007 7:11:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:11:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
| HGNCid = 812
| Symbol = ATP2A2
| AltSymbols =; DAR; ATP2B; DD; MGC45367; SERCA2
| OMIM = 108740
| ECnumber =
| Homologene = 80167
| MGIid = 88110
| GeneAtlas_image1 = PBB_GE_ATP2A2_212361_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATP2A2_209186_at_tn.png
| GeneAtlas_image3 = PBB_GE_ATP2A2_212362_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} {{GNF_GO|id=GO:0048155 |text = S100 alpha binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016529 |text = sarcoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 488
| Hs_Ensembl = ENSG00000174437
| Hs_RefseqProtein = NP_001672
| Hs_RefseqmRNA = NM_001681
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 109203815
| Hs_GenLoc_end = 109273278
| Hs_Uniprot = P16615
| Mm_EntrezGene = 11938
| Mm_Ensembl = ENSMUSG00000029467
| Mm_RefseqmRNA = NM_009722
| Mm_RefseqProtein = NP_033852
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 122703319
| Mm_GenLoc_end = 122762791
| Mm_Uniprot = O54994
}}
}}
'''ATPase, Ca++ transporting, cardiac muscle, slow twitch 2''', also known as '''ATP2A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=488| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=488| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=de Meis L |title=Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. |journal=Biosci. Rep. |volume=21 |issue= 2 |pages= 113-37 |year= 2002 |pmid= 11725862 |doi= }}
*{{cite journal | author=Frank KF, Bölck B, Brixius K, ''et al.'' |title=Modulation of SERCA: implications for the failing human heart. |journal=Basic Res. Cardiol. |volume=97 Suppl 1 |issue= |pages= I72-8 |year= 2002 |pmid= 12479238 |doi= }}
*{{cite journal | author=Ren YQ, Gao M, Liang YH, ''et al.'' |title=Five mutations of ATP2A2 gene in Chinese patients with Darier's disease and a literature review of 86 cases reported in China. |journal=Arch. Dermatol. Res. |volume=298 |issue= 2 |pages= 58-63 |year= 2007 |pmid= 16552539 |doi= 10.1007/s00403-006-0658-0 }}
*{{cite journal | author=Lytton J, MacLennan DH |title=Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. |journal=J. Biol. Chem. |volume=263 |issue= 29 |pages= 15024-31 |year= 1988 |pmid= 2844796 |doi= }}
*{{cite journal | author=Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan DH |title=Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26492-6 |year= 1994 |pmid= 7929371 |doi= }}
*{{cite journal | author=Otsu K, Fujii J, Periasamy M, ''et al.'' |title=Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes. |journal=Genomics |volume=17 |issue= 2 |pages= 507-9 |year= 1993 |pmid= 8406504 |doi= 10.1006/geno.1993.1357 }}
*{{cite journal | author=Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR |title=Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23696-702 |year= 1997 |pmid= 9295312 |doi= }}
*{{cite journal | author=Kuo TH, Kim HR, Zhu L, ''et al.'' |title=Modulation of endoplasmic reticulum calcium pump by Bcl-2. |journal=Oncogene |volume=17 |issue= 15 |pages= 1903-10 |year= 1998 |pmid= 9788433 |doi= 10.1038/sj.onc.1202110 }}
*{{cite journal | author=Sakuntabhai A, Ruiz-Perez V, Carter S, ''et al.'' |title=Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 271-7 |year= 1999 |pmid= 10080178 |doi= 10.1038/6784 }}
*{{cite journal | author=Sakuntabhai A, Burge S, Monk S, Hovnanian A |title=Spectrum of novel ATP2A2 mutations in patients with Darier's disease. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1611-9 |year= 2000 |pmid= 10441323 |doi= }}
*{{cite journal | author=Ruiz-Perez VL, Carter SA, Healy E, ''et al.'' |title=ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1621-30 |year= 2000 |pmid= 10441324 |doi= }}
*{{cite journal | author=Jacobsen NJ, Lyons I, Hoogendoorn B, ''et al.'' |title=ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1631-6 |year= 2000 |pmid= 10441325 |doi= }}
*{{cite journal | author=Asahi M, McKenna E, Kurzydlowski K, ''et al.'' |title=Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15034-8 |year= 2000 |pmid= 10809745 |doi= }}
*{{cite journal | author=Sakuntabhai A, Dhitavat J, Burge S, Hovnanian A |title=Mosaicism for ATP2A2 mutations causes segmental Darier's disease. |journal=J. Invest. Dermatol. |volume=115 |issue= 6 |pages= 1144-7 |year= 2001 |pmid= 11121153 |doi= 10.1046/j.1523-1747.2000.00182.x }}
*{{cite journal | author=Chami M, Gozuacik D, Lagorce D, ''et al.'' |title=SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. |journal=J. Cell Biol. |volume=153 |issue= 6 |pages= 1301-14 |year= 2001 |pmid= 11402072 |doi= }}
*{{cite journal | author=Asahi M, Green NM, Kurzydlowski K, ''et al.'' |title=Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10061-6 |year= 2001 |pmid= 11526231 |doi= 10.1073/pnas.181348298 }}
*{{cite journal | author=Kimura Y, Inui M |title=Reconstitution of the cytoplasmic interaction between phospholamban and Ca(2+)-ATPase of cardiac sarcoplasmic reticulum. |journal=Mol. Pharmacol. |volume=61 |issue= 3 |pages= 667-73 |year= 2002 |pmid= 11854448 |doi= }}
*{{cite journal | author=Münch G, Bölck B, Karczewski P, Schwinger RH |title=Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium. |journal=J. Mol. Cell. Cardiol. |volume=34 |issue= 3 |pages= 321-34 |year= 2002 |pmid= 11945024 |doi= 10.1006/jmcc.2001.1515 }}
*{{cite journal | author=Chao SC, Yang MH, Lee JY |title=Mutation analysis of the ATP2A2 gene in Taiwanese patients with Darier's disease. |journal=Br. J. Dermatol. |volume=146 |issue= 6 |pages= 958-63 |year= 2002 |pmid= 12072062 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BIRC2... {November 15, 2007 7:10:39 PM PST}
- SEARCH REDIRECT: Control Box Found: BIRC2 {November 15, 2007 7:11:07 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:11:08 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:11:08 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:11:08 PM PST}
- UPDATED: Updated protein page: BIRC2 {November 15, 2007 7:11:16 PM PST}
- INFO: Beginning work on BMP7... {November 15, 2007 7:11:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:12:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BMP7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bmp.
| PDB = {{PDB2|1bmp}}, {{PDB2|1lx5}}, {{PDB2|1lxi}}, {{PDB2|1m4u}}
| Name = Bone morphogenetic protein 7 (osteogenic protein 1)
| HGNCid = 1074
| Symbol = BMP7
| AltSymbols =; OP-1
| OMIM = 112267
| ECnumber =
| Homologene = 20410
| MGIid = 103302
| GeneAtlas_image1 = PBB_GE_BMP7_209591_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BMP7_209590_at_tn.png
| GeneAtlas_image3 = PBB_GE_BMP7_211259_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0001822 |text = kidney development}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007435 |text = salivary gland morphogenesis}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0040007 |text = growth}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045597 |text = positive regulation of cell differentiation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0048468 |text = cell development}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}} {{GNF_GO|id=GO:0051216 |text = cartilage development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 655
| Hs_Ensembl = ENSG00000101144
| Hs_RefseqProtein = NP_001710
| Hs_RefseqmRNA = NM_001719
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 55177211
| Hs_GenLoc_end = 55275091
| Hs_Uniprot = P18075
| Mm_EntrezGene = 12162
| Mm_Ensembl = ENSMUSG00000008999
| Mm_RefseqmRNA = NM_007557
| Mm_RefseqProtein = NP_031583
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 172512625
| Mm_GenLoc_end = 172583232
| Mm_Uniprot = P23359
}}
}}
'''Bone morphogenetic protein 7 (osteogenic protein 1)''', also known as '''BMP7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BMP7 bone morphogenetic protein 7 (osteogenic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=655| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.<ref name="entrez">{{cite web | title = Entrez Gene: BMP7 bone morphogenetic protein 7 (osteogenic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=655| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reddi AH |title=Bone morphogenetic proteins and skeletal development: the kidney-bone connection. |journal=Pediatr. Nephrol. |volume=14 |issue= 7 |pages= 598-601 |year= 2000 |pmid= 10912525 |doi= }}
*{{cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
*{{cite journal | author=Brown A, Stock G, Patel AA, ''et al.'' |title=Osteogenic protein-1 : a review of its utility in spinal applications. |journal=BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy |volume=20 |issue= 4 |pages= 243-51 |year= 2007 |pmid= 16831023 |doi= }}
*{{cite journal | author=Hahn GV, Cohen RB, Wozney JM, ''et al.'' |title=A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. |journal=Genomics |volume=14 |issue= 3 |pages= 759-62 |year= 1992 |pmid= 1427904 |doi= }}
*{{cite journal | author=Celeste AJ, Iannazzi JA, Taylor RC, ''et al.'' |title=Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9843-7 |year= 1991 |pmid= 2263636 |doi= }}
*{{cite journal | author=Ozkaynak E, Rueger DC, Drier EA, ''et al.'' |title=OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. |journal=EMBO J. |volume=9 |issue= 7 |pages= 2085-93 |year= 1990 |pmid= 2357959 |doi= }}
*{{cite journal | author=Helder MN, Ozkaynak E, Sampath KT, ''et al.'' |title=Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. |journal=J. Histochem. Cytochem. |volume=43 |issue= 10 |pages= 1035-44 |year= 1995 |pmid= 7560881 |doi= }}
*{{cite journal | author=Liu F, Ventura F, Doody J, Massagué J |title=Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3479-86 |year= 1995 |pmid= 7791754 |doi= }}
*{{cite journal | author=ten Dijke P, Yamashita H, Sampath TK, ''et al.'' |title=Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 16985-8 |year= 1994 |pmid= 8006002 |doi= }}
*{{cite journal | author=Vukicevic S, Latin V, Chen P, ''et al.'' |title=Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: high affinity binding to basement membranes. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 2 |pages= 693-700 |year= 1994 |pmid= 8297380 |doi= 10.1006/bbrc.1994.1100 }}
*{{cite journal | author=Griffith DL, Keck PC, Sampath TK, ''et al.'' |title=Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 878-83 |year= 1996 |pmid= 8570652 |doi= }}
*{{cite journal | author=Yamada N, Kato M, ten Dijke P, ''et al.'' |title=Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours. |journal=Br. J. Cancer |volume=73 |issue= 5 |pages= 624-9 |year= 1996 |pmid= 8605097 |doi= }}
*{{cite journal | author=Macías-Silva M, Hoodless PA, Tang SJ, ''et al.'' |title=Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25628-36 |year= 1998 |pmid= 9748228 |doi= }}
*{{cite journal | author=Barbara NP, Wrana JL, Letarte M |title=Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 584-94 |year= 1999 |pmid= 9872992 |doi= }}
*{{cite journal | author=Dorai H, Shepard A, Ozkaynak E, ''et al.'' |title=The 5' flanking region of the human bone morphogenetic protein-7 gene. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 823-31 |year= 2001 |pmid= 11401538 |doi= 10.1006/bbrc.2001.4645 }}
*{{cite journal | author=Kawai S, Sugiura T |title=Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator. |journal=Bone |volume=29 |issue= 1 |pages= 54-61 |year= 2001 |pmid= 11472891 |doi= }}
*{{cite journal | author=Morrell NW, Yang X, Upton PD, ''et al.'' |title=Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. |journal=Circulation |volume=104 |issue= 7 |pages= 790-5 |year= 2001 |pmid= 11502704 |doi= }}
*{{cite journal | author=Matsaba T, Ramoshebi LN, Crooks J, Ripamonti U |title=Transforming growth factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic protein-1 via the synergistic upregulation of molecular markers. |journal=Growth Factors |volume=19 |issue= 2 |pages= 73-86 |year= 2002 |pmid= 11769973 |doi= }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BTRC... {November 15, 2007 7:21:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:22:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BTRC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p22.
| PDB = {{PDB2|1p22}}
| Name = Beta-transducin repeat containing
| HGNCid = 1144
| Symbol = BTRC
| AltSymbols =; BETA-TRCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP
| OMIM = 603482
| ECnumber =
| Homologene = 39330
| MGIid = 1338871
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8945
| Hs_Ensembl = ENSG00000166167
| Hs_RefseqProtein = NP_003930
| Hs_RefseqmRNA = NM_003939
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 103103810
| Hs_GenLoc_end = 103307068
| Hs_Uniprot = Q9Y297
| Mm_EntrezGene = 12234
| Mm_Ensembl = ENSMUSG00000025217
| Mm_RefseqmRNA = NM_001037758
| Mm_RefseqProtein = NP_001032847
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 45417062
| Mm_GenLoc_end = 45583324
| Mm_Uniprot =
}}
}}
'''Beta-transducin repeat containing''', also known as '''BTRC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BTRC beta-transducin repeat containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8945| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.<ref name="entrez">{{cite web | title = Entrez Gene: BTRC beta-transducin repeat containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8945| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Maniatis T |title=A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. |journal=Genes Dev. |volume=13 |issue= 5 |pages= 505-10 |year= 1999 |pmid= 10072378 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Margottin F, Bour SP, Durand H, ''et al.'' |title=A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. |journal=Mol. Cell |volume=1 |issue= 4 |pages= 565-74 |year= 1998 |pmid= 9660940 |doi= }}
*{{cite journal | author=Yaron A, Hatzubai A, Davis M, ''et al.'' |title=Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. |journal=Nature |volume=396 |issue= 6711 |pages= 590-4 |year= 1999 |pmid= 9859996 |doi= 10.1038/25159 }}
*{{cite journal | author=Winston JT, Strack P, Beer-Romero P, ''et al.'' |title=The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 270-83 |year= 1999 |pmid= 9990852 |doi= }}
*{{cite journal | author=Spencer E, Jiang J, Chen ZJ |title=Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 284-94 |year= 1999 |pmid= 9990853 |doi= }}
*{{cite journal | author=Kitagawa M, Hatakeyama S, Shirane M, ''et al.'' |title=An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. |journal=EMBO J. |volume=18 |issue= 9 |pages= 2401-10 |year= 1999 |pmid= 10228155 |doi= 10.1093/emboj/18.9.2401 }}
*{{cite journal | author=Fujiwara T, Suzuki M, Tanigami A, ''et al.'' |title=The BTRC gene, encoding a human F-box/WD40-repeat protein, maps to chromosome 10q24-q25. |journal=Genomics |volume=58 |issue= 1 |pages= 104-5 |year= 1999 |pmid= 10331953 |doi= 10.1006/geno.1999.5792 }}
*{{cite journal | author=Wu C, Ghosh S |title=beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29591-4 |year= 1999 |pmid= 10514424 |doi= }}
*{{cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, ''et al.'' |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177-9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2 }}
*{{cite journal | author=Stone DM, Murone M, Luoh S, ''et al.'' |title=Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. |journal=J. Cell. Sci. |volume=112 ( Pt 23) |issue= |pages= 4437-48 |year= 2000 |pmid= 10564661 |doi= }}
*{{cite journal | author=Suzuki H, Chiba T, Suzuki T, ''et al.'' |title=Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2877-84 |year= 2000 |pmid= 10644755 |doi= }}
*{{cite journal | author=Read MA, Brownell JE, Gladysheva TB, ''et al.'' |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326-33 |year= 2000 |pmid= 10713156 |doi= }}
*{{cite journal | author=Sadot E, Simcha I, Iwai K, ''et al.'' |title=Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system. |journal=Oncogene |volume=19 |issue= 16 |pages= 1992-2001 |year= 2000 |pmid= 10803460 |doi= 10.1038/sj.onc.1203519 }}
*{{cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, ''et al.'' |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255-8 |year= 2000 |pmid= 10828603 |doi= }}
*{{cite journal | author=Orian A, Gonen H, Bercovich B, ''et al.'' |title=SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2580-91 |year= 2000 |pmid= 10835356 |doi= 10.1093/emboj/19.11.2580 }}
*{{cite journal | author=Strack P, Caligiuri M, Pelletier M, ''et al.'' |title=SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. |journal=Oncogene |volume=19 |issue= 31 |pages= 3529-36 |year= 2000 |pmid= 10918611 |doi= 10.1038/sj.onc.1203647 }}
*{{cite journal | author=Kleijnen MF, Shih AH, Zhou P, ''et al.'' |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409-19 |year= 2000 |pmid= 10983987 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DDIT3... {November 15, 2007 7:12:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:13:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DNA-damage-inducible transcript 3
| HGNCid = 2726
| Symbol = DDIT3
| AltSymbols =; CEBPZ; CHOP; CHOP10; GADD153; MGC4154
| OMIM = 126337
| ECnumber =
| Homologene = 3012
| MGIid = 109247
| GeneAtlas_image1 = PBB_GE_DDIT3_209383_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0030503 |text = regulation of cell redox homeostasis}} {{GNF_GO|id=GO:0030968 |text = unfolded protein response}} {{GNF_GO|id=GO:0042789 |text = mRNA transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1649
| Hs_Ensembl = ENSG00000175197
| Hs_RefseqProtein = NP_004074
| Hs_RefseqmRNA = NM_004083
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56196640
| Hs_GenLoc_end = 56200567
| Hs_Uniprot = P35638
| Mm_EntrezGene = 13198
| Mm_Ensembl = ENSMUSG00000025408
| Mm_RefseqmRNA = NM_007837
| Mm_RefseqProtein = NP_031863
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 126693757
| Mm_GenLoc_end = 126699237
| Mm_Uniprot = Q3V405
}}
}}
'''DNA-damage-inducible transcript 3''', also known as '''DDIT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDIT3 DNA-damage-inducible transcript 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ramji DP, Foka P |title=CCAAT/enhancer-binding proteins: structure, function and regulation. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 561-75 |year= 2002 |pmid= 12006103 |doi= 10.1042/BJ20020508 }}
*{{cite journal | author=Oyadomari S, Mori M |title=Roles of CHOP/GADD153 in endoplasmic reticulum stress. |journal=Cell Death Differ. |volume=11 |issue= 4 |pages= 381-9 |year= 2004 |pmid= 14685163 |doi= 10.1038/sj.cdd.4401373 }}
*{{cite journal | author=Aman P, Ron D, Mandahl N, ''et al.'' |title=Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). |journal=Genes Chromosomes Cancer |volume=5 |issue= 4 |pages= 278-85 |year= 1993 |pmid= 1283316 |doi= }}
*{{cite journal | author=Park JS, Luethy JD, Wang MG, ''et al.'' |title=Isolation, characterization and chromosomal localization of the human GADD153 gene. |journal=Gene |volume=116 |issue= 2 |pages= 259-67 |year= 1992 |pmid= 1339368 |doi= }}
*{{cite journal | author=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439-53 |year= 1992 |pmid= 1547942 |doi= }}
*{{cite journal | author=Papathanasiou MA, Kerr NC, Robbins JH, ''et al.'' |title=Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1009-16 |year= 1991 |pmid= 1990262 |doi= }}
*{{cite journal | author=Eneroth M, Mandahl N, Heim S, ''et al.'' |title=Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2. |journal=Cancer Genet. Cytogenet. |volume=48 |issue= 1 |pages= 101-7 |year= 1990 |pmid= 2372777 |doi= }}
*{{cite journal | author=Rabbitts TH, Forster A, Larson R, Nathan P |title=Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 175-80 |year= 1993 |pmid= 7503811 |doi= 10.1038/ng0693-175 }}
*{{cite journal | author=Crozat A, Aman P, Mandahl N, Ron D |title=Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. |journal=Nature |volume=363 |issue= 6430 |pages= 640-4 |year= 1993 |pmid= 8510758 |doi= 10.1038/363640a0 }}
*{{cite journal | author=Chen BP, Wolfgang CD, Hai T |title=Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1157-68 |year= 1996 |pmid= 8622660 |doi= }}
*{{cite journal | author=Panagopoulos I, Höglund M, Mertens F, ''et al.'' |title=Fusion of the EWS and CHOP genes in myxoid liposarcoma. |journal=Oncogene |volume=12 |issue= 3 |pages= 489-94 |year= 1996 |pmid= 8637704 |doi= }}
*{{cite journal | author=Wang XZ, Ron D |title=Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. |journal=Science |volume=272 |issue= 5266 |pages= 1347-9 |year= 1996 |pmid= 8650547 |doi= }}
*{{cite journal | author=Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ |title=Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14285-9 |year= 1996 |pmid= 8662954 |doi= }}
*{{cite journal | author=Ubeda M, Vallejo M, Habener JF |title=CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7589-99 |year= 1999 |pmid= 10523647 |doi= }}
*{{cite journal | author=Cui K, Coutts M, Stahl J, Sytkowski AJ |title=Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7591-6 |year= 2000 |pmid= 10713066 |doi= }}
*{{cite journal | author=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343-50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200 }}
*{{cite journal | author=Satoh T, Toyoda M, Hoshino H, ''et al.'' |title=Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. |journal=Oncogene |volume=21 |issue= 14 |pages= 2171-80 |year= 2002 |pmid= 11948400 |doi= 10.1038/sj.onc.1205279 }}
*{{cite journal | author=Qiao D, Im E, Qi W, Martinez JD |title=Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis. |journal=Biochim. Biophys. Acta |volume=1583 |issue= 1 |pages= 108-16 |year= 2002 |pmid= 12069855 |doi= }}
*{{cite journal | author=Talukder AH, Wang RA, Kumar R |title=Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells. |journal=Oncogene |volume=21 |issue= 27 |pages= 4289-300 |year= 2002 |pmid= 12082616 |doi= 10.1038/sj.onc.1205529 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EIF4EBP1... {November 15, 2007 7:13:28 PM PST}
- SEARCH REDIRECT: Control Box Found: EIF4EBP1 {November 15, 2007 7:13:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:14:00 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:14:00 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:14:00 PM PST}
- UPDATED: Updated protein page: EIF4EBP1 {November 15, 2007 7:14:08 PM PST}
- INFO: Beginning work on FCGR2B... {November 15, 2007 7:14:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:14:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FCGR2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fcg.
| PDB = {{PDB2|1fcg}}, {{PDB2|1h9v}}, {{PDB2|2fcb}}
| Name = Fc fragment of IgG, low affinity IIb, receptor (CD32)
| HGNCid = 3618
| Symbol = FCGR2B
| AltSymbols =; CD32; FCG2; FCGR2; IGFR2; CD32B
| OMIM = 604590
| ECnumber =
| Homologene = 2974
| MGIid = 95499
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019864 |text = IgG binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2213
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001129592
| Hs_RefseqmRNA = XM_001129592
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14130
| Mm_Ensembl = ENSMUSG00000026656
| Mm_RefseqmRNA = NM_001077189
| Mm_RefseqProtein = NP_001070657
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 172797236
| Mm_GenLoc_end = 172812709
| Mm_Uniprot = P97918
}}
}}
'''Fc fragment of IgG, low affinity IIb, receptor (CD32)''', also known as '''FCGR2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2213| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsuchiya N, Kyogoku C |title=Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia. |journal=Autoimmunity |volume=38 |issue= 5 |pages= 347-52 |year= 2005 |pmid= 16227149 |doi= 10.1080/08916930500123926 }}
*{{cite journal | author=Qiu WQ, de Bruin D, Brownstein BH, ''et al.'' |title=Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. |journal=Science |volume=248 |issue= 4956 |pages= 732-5 |year= 1990 |pmid= 2139735 |doi= }}
*{{cite journal | author=Engelhardt W, Geerds C, Frey J |title=Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II. |journal=Eur. J. Immunol. |volume=20 |issue= 6 |pages= 1367-77 |year= 1990 |pmid= 2142460 |doi= }}
*{{cite journal | author=Seki T |title=Identification of multiple isoforms of the low-affinity human IgG Fc receptor. |journal=Immunogenetics |volume=30 |issue= 1 |pages= 5-12 |year= 1989 |pmid= 2526077 |doi= }}
*{{cite journal | author=Brooks DG, Qiu WQ, Luster AD, Ravetch JV |title=Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1369-85 |year= 1989 |pmid= 2529342 |doi= }}
*{{cite journal | author=Stuart SG, Simister NE, Clarkson SB, ''et al.'' |title=Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3657-66 |year= 1990 |pmid= 2531080 |doi= }}
*{{cite journal | author=Stengelin S, Stamenkovic I, Seed B |title=Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. |journal=EMBO J. |volume=7 |issue= 4 |pages= 1053-9 |year= 1988 |pmid= 3402431 |doi= }}
*{{cite journal | author=Engelhardt W, Matzke J, Schmidt RE |title=Activation-dependent expression of low affinity IgG receptors Fc gamma RII(CD32) and Fc gamma RIII(CD16) in subpopulations of human T lymphocytes. |journal=Immunobiology |volume=192 |issue= 5 |pages= 297-320 |year= 1995 |pmid= 7649565 |doi= }}
*{{cite journal | author=D'Ambrosio D, Hippen KL, Minskoff SA, ''et al.'' |title=Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. |journal=Science |volume=268 |issue= 5208 |pages= 293-7 |year= 1995 |pmid= 7716523 |doi= }}
*{{cite journal | author=Warmerdam PA, van den Herik-Oudijk IE, Parren PW, ''et al.'' |title=Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses. |journal=Int. Immunol. |volume=5 |issue= 3 |pages= 239-47 |year= 1993 |pmid= 8466861 |doi= }}
*{{cite journal | author=Bewarder N, Weinrich V, Budde P, ''et al.'' |title=In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4735-43 |year= 1996 |pmid= 8756631 |doi= }}
*{{cite journal | author=Sandilands GP, MacPherson SA, Burnett ER, ''et al.'' |title=Differential expression of CD32 isoforms following alloactivation of human T cells. |journal=Immunology |volume=91 |issue= 2 |pages= 204-11 |year= 1997 |pmid= 9227318 |doi= }}
*{{cite journal | author=De SK, Venkateshan CN, Seth P, ''et al.'' |title=Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines. |journal=Blood |volume=91 |issue= 6 |pages= 2108-17 |year= 1998 |pmid= 9490697 |doi= }}
*{{cite journal | author=Metes D, Ernst LK, Chambers WH, ''et al.'' |title=Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. |journal=Blood |volume=91 |issue= 7 |pages= 2369-80 |year= 1998 |pmid= 9516136 |doi= }}
*{{cite journal | author=Sondermann P, Huber R, Jacob U |title=Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1095-103 |year= 1999 |pmid= 10064577 |doi= 10.1093/emboj/18.5.1095 }}
*{{cite journal | author=Muraille E, Bruhns P, Pesesse X, ''et al.'' |title=The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. |journal=Immunol. Lett. |volume=72 |issue= 1 |pages= 7-15 |year= 2000 |pmid= 10789675 |doi= }}
*{{cite journal | author=Pricop L, Redecha P, Teillaud JL, ''et al.'' |title=Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines. |journal=J. Immunol. |volume=166 |issue= 1 |pages= 531-7 |year= 2001 |pmid= 11123333 |doi= }}
*{{cite journal | author=Lyden TW, Robinson JM, Tridandapani S, ''et al.'' |title=The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2. |journal=J. Immunol. |volume=166 |issue= 6 |pages= 3882-9 |year= 2001 |pmid= 11238632 |doi= }}
*{{cite journal | author=Bharadwaj D, Mold C, Markham E, Du Clos TW |title=Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. |journal=J. Immunol. |volume=166 |issue= 11 |pages= 6735-41 |year= 2001 |pmid= 11359830 |doi= }}
*{{cite journal | author=Jessup CF, Ridings J, Ho A, ''et al.'' |title=The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes. |journal=Hum. Immunol. |volume=62 |issue= 7 |pages= 679-85 |year= 2001 |pmid= 11423173 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FGF7... {November 15, 2007 7:14:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:15:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGF7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qqk.
| PDB = {{PDB2|1qqk}}
| Name = Fibroblast growth factor 7 (keratinocyte growth factor)
| HGNCid = 3685
| Symbol = FGF7
| AltSymbols =; HBGF-7; KGF
| OMIM = 148180
| ECnumber =
| Homologene = 7316
| MGIid = 95521
| GeneAtlas_image1 = PBB_GE_FGF7_205782_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2252
| Hs_Ensembl = ENSG00000140285
| Hs_RefseqProtein = NP_002000
| Hs_RefseqmRNA = NM_002009
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 47502751
| Hs_GenLoc_end = 47566815
| Hs_Uniprot = P21781
| Mm_EntrezGene = 14178
| Mm_Ensembl = ENSMUSG00000027208
| Mm_RefseqmRNA = NM_008008
| Mm_RefseqProtein = NP_032034
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 125726225
| Mm_GenLoc_end = 125781969
| Mm_Uniprot = Q544I6
}}
}}
'''Fibroblast growth factor 7 (keratinocyte growth factor)''', also known as '''FGF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beer HD, Gassmann MG, Munz B, ''et al.'' |title=Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. |journal=J. Investig. Dermatol. Symp. Proc. |volume=5 |issue= 1 |pages= 34-9 |year= 2001 |pmid= 11147673 |doi= 10.1046/j.1087-0024.2000.00009.x }}
*{{cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924-40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001 }}
*{{cite journal | author=Finch PW, Rubin JS |title=Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. |journal=Adv. Cancer Res. |volume=91 |issue= |pages= 69-136 |year= 2004 |pmid= 15327889 |doi= 10.1016/S0065-230X(04)91003-2 }}
*{{cite journal | author=Ishibashi T, Bottaro DP, Chan A, ''et al.'' |title=Expression cloning of a human dual-specificity phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 24 |pages= 12170-4 |year= 1993 |pmid= 1281549 |doi= }}
*{{cite journal | author=Kelley MJ, Pech M, Seuanez HN, ''et al.'' |title=Emergence of the keratinocyte growth factor multigene family during the great ape radiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9287-91 |year= 1992 |pmid= 1409637 |doi= }}
*{{cite journal | author=Aaronson SA, Bottaro DP, Miki T, ''et al.'' |title=Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. |journal=Ann. N. Y. Acad. Sci. |volume=638 |issue= |pages= 62-77 |year= 1992 |pmid= 1664700 |doi= }}
*{{cite journal | author=Finch PW, Rubin JS, Miki T, ''et al.'' |title=Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. |journal=Science |volume=245 |issue= 4919 |pages= 752-5 |year= 1989 |pmid= 2475908 |doi= }}
*{{cite journal | author=Rubin JS, Osada H, Finch PW, ''et al.'' |title=Purification and characterization of a newly identified growth factor specific for epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 3 |pages= 802-6 |year= 1989 |pmid= 2915979 |doi= }}
*{{cite journal | author=Ron D, Reich R, Chedid M, ''et al.'' |title=Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5388-94 |year= 1993 |pmid= 7680645 |doi= }}
*{{cite journal | author=Yan G, Fukabori Y, McBride G, ''et al.'' |title=Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4513-22 |year= 1993 |pmid= 7687739 |doi= }}
*{{cite journal | author=Mattei MG, deLapeyrière O, Bresnick J, ''et al.'' |title=Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. |journal=Mamm. Genome |volume=6 |issue= 3 |pages= 196-7 |year= 1995 |pmid= 7749227 |doi= }}
*{{cite journal | author=Werner S, Smola H, Liao X, ''et al.'' |title=The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. |journal=Science |volume=266 |issue= 5186 |pages= 819-22 |year= 1994 |pmid= 7973639 |doi= }}
*{{cite journal | author=Wilson SE, Walker JW, Chwang EL, He YG |title=Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. |journal=Invest. Ophthalmol. Vis. Sci. |volume=34 |issue= 8 |pages= 2544-61 |year= 1993 |pmid= 8392040 |doi= }}
*{{cite journal | author=Guo L, Degenstein L, Fuchs E |title=Keratinocyte growth factor is required for hair development but not for wound healing. |journal=Genes Dev. |volume=10 |issue= 2 |pages= 165-75 |year= 1996 |pmid= 8566750 |doi= }}
*{{cite journal | author=Ornitz DM, Xu J, Colvin JS, ''et al.'' |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292-7 |year= 1996 |pmid= 8663044 |doi= }}
*{{cite journal | author=Post M, Souza P, Liu J, ''et al.'' |title=Keratinocyte growth factor and its receptor are involved in regulating early lung branching. |journal=Development |volume=122 |issue= 10 |pages= 3107-15 |year= 1996 |pmid= 8898224 |doi= }}
*{{cite journal | author=Zimonjic DB, Kelley MJ, Rubin JS, ''et al.'' |title=Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11461-5 |year= 1997 |pmid= 9326632 |doi= }}
*{{cite journal | author=Winkles JA, Alberts GF, Chedid M, ''et al.'' |title=Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. |journal=J. Cell. Physiol. |volume=173 |issue= 3 |pages= 380-6 |year= 1997 |pmid= 9369951 |doi= 10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G }}
*{{cite journal | author=Ishibashi T, Tanaka T, Nibu K, ''et al.'' |title=Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps. |journal=Ann. Otol. Rhinol. Laryngol. |volume=107 |issue= 10 Pt 1 |pages= 885-90 |year= 1998 |pmid= 9794620 |doi= }}
*{{cite journal | author=Mongiat M, Taylor K, Otto J, ''et al.'' |title=The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7095-100 |year= 2000 |pmid= 10702276 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTATIP... {November 15, 2007 7:23:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:23:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HTATIP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ou2.
| PDB = {{PDB2|2ou2}}
| Name = HIV-1 Tat interacting protein, 60kDa
| HGNCid = 5275
| Symbol = HTATIP
| AltSymbols =; ESA1; HTATIP1; PLIP; TIP; TIP60; cPLA2
| OMIM = 601409
| ECnumber =
| Homologene = 4657
| MGIid = 1932051
| GeneAtlas_image1 = PBB_GE_HTATIP_206689_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTATIP_209192_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_HTATIP_214258_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0035267 |text = NuA4 histone acetyltransferase complex}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0016573 |text = histone acetylation}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10524
| Hs_Ensembl = ENSG00000172977
| Hs_RefseqProtein = NP_006379
| Hs_RefseqmRNA = NM_006388
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 65236315
| Hs_GenLoc_end = 65243650
| Hs_Uniprot = Q92993
| Mm_EntrezGene = 81601
| Mm_Ensembl = ENSMUSG00000024926
| Mm_RefseqmRNA = NM_178637
| Mm_RefseqProtein = NP_848752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 5603418
| Mm_GenLoc_end = 5610029
| Mm_Uniprot = Q3UJQ1
}}
}}
'''HIV-1 Tat interacting protein, 60kDa''', also known as '''HTATIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10524| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10524| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal | author=Sapountzi V, Logan IR, Robson CN |title=Cellular functions of TIP60. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 9 |pages= 1496-509 |year= 2006 |pmid= 16698308 |doi= 10.1016/j.biocel.2006.03.003 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Kamine J, Elangovan B, Subramanian T, ''et al.'' |title=Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. |journal=Virology |volume=216 |issue= 2 |pages= 357-66 |year= 1996 |pmid= 8607265 |doi= 10.1006/viro.1996.0071 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Yamamoto T, Horikoshi M |title=Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30595-8 |year= 1998 |pmid= 9388189 |doi= }}
*{{cite journal | author=Kimura A, Horikoshi M |title=Tip60 acetylates six lysines of a specific class in core histones in vitro. |journal=Genes Cells |volume=3 |issue= 12 |pages= 789-800 |year= 1999 |pmid= 10096020 |doi= }}
*{{cite journal | author=Dechend R, Hirano F, Lehmann K, ''et al.'' |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316-23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717 }}
*{{cite journal | author=Brady ME, Ozanne DM, Gaughan L, ''et al.'' |title=Tip60 is a nuclear hormone receptor coactivator. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17599-604 |year= 1999 |pmid= 10364196 |doi= }}
*{{cite journal | author=Creaven M, Hans F, Mutskov V, ''et al.'' |title=Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat. |journal=Biochemistry |volume=38 |issue= 27 |pages= 8826-30 |year= 1999 |pmid= 10393559 |doi= 10.1021/bi9907274 }}
*{{cite journal | author=Sliva D, Zhu YX, Tsai S, ''et al.'' |title=Tip60 interacts with human interleukin-9 receptor alpha-chain. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 149-55 |year= 1999 |pmid= 10486269 |doi= 10.1006/bbrc.1999.1083 }}
*{{cite journal | author=Gavaravarapu S, Kamine J |title=Tip60 inhibits activation of CREB protein by protein kinase A. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 3 |pages= 758-66 |year= 2000 |pmid= 10720489 |doi= 10.1006/bbrc.2000.2358 }}
*{{cite journal | author=Husi H, Ward MA, Choudhary JS, ''et al.'' |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661-9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 }}
*{{cite journal | author=Ikura T, Ogryzko VV, Grigoriev M, ''et al.'' |title=Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. |journal=Cell |volume=102 |issue= 4 |pages= 463-73 |year= 2000 |pmid= 10966108 |doi= }}
*{{cite journal | author=Ran Q, Pereira-Smith OM |title=Identification of an alternatively spliced form of the Tat interactive protein (Tip60), Tip60(beta). |journal=Gene |volume=258 |issue= 1-2 |pages= 141-6 |year= 2001 |pmid= 11111051 |doi= }}
*{{cite journal | author=Lee HJ, Chun M, Kandror KV |title=Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 16597-600 |year= 2001 |pmid= 11262386 |doi= 10.1074/jbc.C000909200 }}
*{{cite journal | author=Hlubek F, Löhberg C, Meiler J, ''et al.'' |title=Tip60 is a cell-type-specific transcriptional regulator. |journal=J. Biochem. |volume=129 |issue= 4 |pages= 635-41 |year= 2001 |pmid= 11275565 |doi= }}
*{{cite journal | author=Sheridan AM, Force T, Yoon HJ, ''et al.'' |title=PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4470-81 |year= 2001 |pmid= 11416127 |doi= 10.1128/MCB.21.14.4470-4481.2001 }}
*{{cite journal | author=Cao X, Südhof TC |title=A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. |journal=Science |volume=293 |issue= 5527 |pages= 115-20 |year= 2001 |pmid= 11441186 |doi= 10.1126/science.1058783 }}
*{{cite journal | author=Legube G, Linares LK, Lemercier C, ''et al.'' |title=Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. |journal=EMBO J. |volume=21 |issue= 7 |pages= 1704-12 |year= 2002 |pmid= 11927554 |doi= 10.1093/emboj/21.7.1704 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1A... {November 15, 2007 7:15:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:15:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1A
| HGNCid = 5286
| Symbol = HTR1A
| AltSymbols =; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1
| OMIM = 109760
| ECnumber =
| Homologene = 20148
| MGIid = 96273
| GeneAtlas_image1 = PBB_GE_HTR1A_221351_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3350
| Hs_Ensembl = ENSG00000178394
| Hs_RefseqProtein = NP_000515
| Hs_RefseqmRNA = NM_000524
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 63292034
| Hs_GenLoc_end = 63293302
| Hs_Uniprot = P08908
| Mm_EntrezGene = 15550
| Mm_Ensembl = ENSMUSG00000021721
| Mm_RefseqmRNA = NM_008308
| Mm_RefseqProtein = NP_032334
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 106564148
| Mm_GenLoc_end = 106568501
| Mm_Uniprot = Q8BGS4
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1A''', also known as '''HTR1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3350| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=el Mestikawy S, Fargin A, Raymond JR, ''et al.'' |title=The 5-HT1A receptor: an overview of recent advances. |journal=Neurochem. Res. |volume=16 |issue= 1 |pages= 1-10 |year= 1991 |pmid= 2052135 |doi= }}
*{{cite journal | author=Hensler JG |title=Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. |journal=Life Sci. |volume=72 |issue= 15 |pages= 1665-82 |year= 2003 |pmid= 12559389 |doi= }}
*{{cite journal | author=Van Oekelen D, Luyten WH, Leysen JE |title=5-HT2A and 5-HT2C receptors and their atypical regulation properties. |journal=Life Sci. |volume=72 |issue= 22 |pages= 2429-49 |year= 2003 |pmid= 12650852 |doi= }}
*{{cite journal | author=Lesch KP, Gutknecht L |title=Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics. |journal=Int. J. Neuropsychopharmacol. |volume=7 |issue= 4 |pages= 381-5 |year= 2005 |pmid= 15683551 |doi= 10.1017/S1461145704004845 }}
*{{cite journal | author=Kalipatnapu S, Chattopadhyay A |title=Membrane protein solubilization: recent advances and challenges in solubilization of serotonin1A receptors. |journal=IUBMB Life |volume=57 |issue= 7 |pages= 505-12 |year= 2006 |pmid= 16081372 |doi= 10.1080/15216540500167237 }}
*{{cite journal | author=Varrault A, Bockaert J, Waeber C |title=Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. |journal=Mol. Biol. Cell |volume=3 |issue= 9 |pages= 961-9 |year= 1992 |pmid= 1330092 |doi= }}
*{{cite journal | author=Levy FO, Gudermann T, Perez-Reyes E, ''et al.'' |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553-62 |year= 1992 |pmid= 1559993 |doi= }}
*{{cite journal | author=Melmer G, Sherrington R, Mankoo B, ''et al.'' |title=A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76. |journal=Genomics |volume=11 |issue= 3 |pages= 767-9 |year= 1992 |pmid= 1685484 |doi= }}
*{{cite journal | author=Parks CL, Chang LS, Shenk T |title=A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region. |journal=Nucleic Acids Res. |volume=19 |issue= 25 |pages= 7155-60 |year= 1992 |pmid= 1766875 |doi= }}
*{{cite journal | author=Gilliam TC, Freimer NB, Kaufmann CA, ''et al.'' |title=Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. |journal=Genomics |volume=5 |issue= 4 |pages= 940-4 |year= 1990 |pmid= 2591972 |doi= }}
*{{cite journal | author=Kobilka BK, Frielle T, Collins S, ''et al.'' |title=An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. |journal=Nature |volume=329 |issue= 6134 |pages= 75-9 |year= 1987 |pmid= 3041227 |doi= 10.1038/329075a0 }}
*{{cite journal | author=Fargin A, Raymond JR, Lohse MJ, ''et al.'' |title=The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. |journal=Nature |volume=335 |issue= 6188 |pages= 358-60 |year= 1988 |pmid= 3138543 |doi= 10.1038/335358a0 }}
*{{cite journal | author=Nakhai B, Nielsen DA, Linnoila M, Goldman D |title=Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. |journal=Biochem. Biophys. Res. Commun. |volume=210 |issue= 2 |pages= 530-6 |year= 1995 |pmid= 7755630 |doi= }}
*{{cite journal | author=Aune TM, McGrath KM, Sarr T, ''et al.'' |title=Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. |journal=J. Immunol. |volume=151 |issue= 3 |pages= 1175-83 |year= 1993 |pmid= 8393041 |doi= }}
*{{cite journal | author=Parks CL, Shenk T |title=The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4417-30 |year= 1996 |pmid= 8626793 |doi= }}
*{{cite journal | author=Stockmeier CA, Shapiro LA, Dilley GE, ''et al.'' |title=Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. |journal=J. Neurosci. |volume=18 |issue= 18 |pages= 7394-401 |year= 1998 |pmid= 9736659 |doi= }}
*{{cite journal | author=Kawanishi Y, Harada S, Tachikawa H, ''et al.'' |title=Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. |journal=Am. J. Med. Genet. |volume=81 |issue= 5 |pages= 434-9 |year= 1998 |pmid= 9754630 |doi= }}
*{{cite journal | author=Price JC, Kelley DE, Ryan CM, ''et al.'' |title=Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study. |journal=Brain Res. |volume=927 |issue= 1 |pages= 97-103 |year= 2002 |pmid= 11814436 |doi= }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MUC5AC... {November 15, 2007 7:16:24 PM PST}
- SEARCH REDIRECT: Control Box Found: MUC5AC {November 15, 2007 7:16:43 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:16:45 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:16:45 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:16:45 PM PST}
- UPDATED: Updated protein page: MUC5AC {November 15, 2007 7:16:51 PM PST}
- INFO: Beginning work on MYB... {November 15, 2007 7:16:51 PM PST}
- SEARCH REDIRECT: Control Box Found: MYB {November 15, 2007 7:17:23 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:17:24 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:17:24 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:17:24 PM PST}
- UPDATED: Updated protein page: MYB {November 15, 2007 7:17:32 PM PST}
- INFO: Beginning work on ND6... {November 15, 2007 7:15:56 PM PST}
- SEARCH REDIRECT: Control Box Found: ND6 {November 15, 2007 7:16:16 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:16:18 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:16:18 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:16:18 PM PST}
- UPDATED: Updated protein page: ND6 {November 15, 2007 7:16:24 PM PST}
- INFO: Beginning work on NR3C2... {November 15, 2007 7:15:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:15:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR3C2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gdc.
| PDB = {{PDB2|1gdc}}, {{PDB2|1rgd}}, {{PDB2|1y9r}}, {{PDB2|1ya3}}, {{PDB2|2a3i}}, {{PDB2|2aa2}}, {{PDB2|2aa5}}, {{PDB2|2aa6}}, {{PDB2|2aa7}}, {{PDB2|2aax}}, {{PDB2|2ab2}}, {{PDB2|2abi}}, {{PDB2|2gda}}
| Name = Nuclear receptor subfamily 3, group C, member 2
| HGNCid = 7979
| Symbol = NR3C2
| AltSymbols =; MCR; MGC133092; MLR; MR
| OMIM = 600983
| ECnumber =
| Homologene = 694
| MGIid = 99459
| GeneAtlas_image1 = PBB_GE_NR3C2_205259_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006883 |text = cellular sodium ion homeostasis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4306
| Hs_Ensembl = ENSG00000151623
| Hs_RefseqProtein = NP_000892
| Hs_RefseqmRNA = NM_000901
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 149219370
| Hs_GenLoc_end = 149582973
| Hs_Uniprot = P08235
| Mm_EntrezGene = 110784
| Mm_Ensembl = ENSMUSG00000031618
| Mm_RefseqmRNA = XM_899576
| Mm_RefseqProtein = XP_904669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 79804344
| Mm_GenLoc_end = 80138602
| Mm_Uniprot = Q3UW58
}}
}}
'''Nuclear receptor subfamily 3, group C, member 2''', also known as '''NR3C2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR3C2 nuclear receptor subfamily 3, group C, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4306| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hellal-Levy C, Fagart J, Souque A, Rafestin-Oblin ME |title=Mechanistic aspects of mineralocorticoid receptor activation. |journal=Kidney Int. |volume=57 |issue= 4 |pages= 1250-5 |year= 2000 |pmid= 10760050 |doi= 10.1046/j.1523-1755.2000.00958.x }}
*{{cite journal | author=Sheppard KE |title=Nuclear receptors. II. Intestinal corticosteroid receptors. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 5 |pages= G742-6 |year= 2002 |pmid= 11960770 |doi= 10.1152/ajpgi.00531.2001 }}
*{{cite journal | author=Kjellander CG |title=[The psychotherapeutic society--utopia or nightmare?] |journal=Lakartidningen |volume=72 |issue= 12 |pages= 1160-1 |year= 1975 |pmid= 1134129 |doi= }}
*{{cite journal | author=Alnemri ES, Maksymowych AB, Robertson NM, Litwack G |title=Overexpression and characterization of the human mineralocorticoid receptor. |journal=J. Biol. Chem. |volume=266 |issue= 27 |pages= 18072-81 |year= 1991 |pmid= 1655735 |doi= }}
*{{cite journal | author=Morrison N, Harrap SB, Arriza JL, ''et al.'' |title=Regional chromosomal assignment of the human mineralocorticoid receptor gene to 4q31.1. |journal=Hum. Genet. |volume=85 |issue= 1 |pages= 130-2 |year= 1990 |pmid= 2162806 |doi= }}
*{{cite journal | author=Fan YS, Eddy RL, Byers MG, ''et al.'' |title=The human mineralocorticoid receptor gene (MLR) is located on chromosome 4 at q31.2. |journal=Cytogenet. Cell Genet. |volume=52 |issue= 1-2 |pages= 83-4 |year= 1990 |pmid= 2558856 |doi= }}
*{{cite journal | author=Arriza JL, Weinberger C, Cerelli G, ''et al.'' |title=Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. |journal=Science |volume=237 |issue= 4812 |pages= 268-75 |year= 1987 |pmid= 3037703 |doi= }}
*{{cite journal | author=Bloem LJ, Guo C, Pratt JH |title=Identification of a splice variant of the rat and human mineralocorticoid receptor genes. |journal=J. Steroid Biochem. Mol. Biol. |volume=55 |issue= 2 |pages= 159-62 |year= 1996 |pmid= 7495694 |doi= }}
*{{cite journal | author=Jalaguier S, Mornet D, Mesnier D, ''et al.'' |title=Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation. |journal=FEBS Lett. |volume=384 |issue= 2 |pages= 112-6 |year= 1996 |pmid= 8612804 |doi= }}
*{{cite journal | author=Thénot S, Henriquet C, Rochefort H, Cavaillès V |title=Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12062-8 |year= 1997 |pmid= 9115274 |doi= }}
*{{cite journal | author=Zennaro MC, Farman N, Bonvalet JP, Lombès M |title=Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 5 |pages= 1345-52 |year= 1997 |pmid= 9141514 |doi= }}
*{{cite journal | author=Bruner KL, Derfoul A, Robertson NM, ''et al.'' |title=The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. |journal=Receptors & signal transduction |volume=7 |issue= 2 |pages= 85-98 |year= 1998 |pmid= 9392437 |doi= }}
*{{cite journal | author=Geller DS, Rodriguez-Soriano J, Vallo Boado A, ''et al.'' |title=Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. |journal=Nat. Genet. |volume=19 |issue= 3 |pages= 279-81 |year= 1998 |pmid= 9662404 |doi= 10.1038/966 }}
*{{cite journal | author=Lupo B, Mesnier D, Auzou G |title=Cysteines 849 and 942 of human mineralocorticoid receptor are crucial for steroid binding. |journal=Biochemistry |volume=37 |issue= 35 |pages= 12153-9 |year= 1998 |pmid= 9724527 |doi= 10.1021/bi980593e }}
*{{cite journal | author=Halushka MK, Fan JB, Bentley K, ''et al.'' |title=Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 239-47 |year= 1999 |pmid= 10391210 |doi= 10.1038/10297 }}
*{{cite journal | author=Freeman BC, Felts SJ, Toft DO, Yamamoto KR |title=The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. |journal=Genes Dev. |volume=14 |issue= 4 |pages= 422-34 |year= 2000 |pmid= 10691735 |doi= }}
*{{cite journal | author=Geller DS, Farhi A, Pinkerton N, ''et al.'' |title=Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. |journal=Science |volume=289 |issue= 5476 |pages= 119-23 |year= 2000 |pmid= 10884226 |doi= }}
*{{cite journal | author=Hellal-Levy C, Fagart J, Souque A, ''et al.'' |title=Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor. |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1210-21 |year= 2001 |pmid= 10935545 |doi= }}
*{{cite journal | author=Watzka M, Beyenburg S, Blümcke I, ''et al.'' |title=Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus. |journal=Neurosci. Lett. |volume=290 |issue= 2 |pages= 121-4 |year= 2000 |pmid= 10936692 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on P4HB... {November 15, 2007 7:17:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:18:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_P4HB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bjx.
| PDB = {{PDB2|1bjx}}, {{PDB2|1mek}}, {{PDB2|1x5c}}, {{PDB2|2bjx}}
| Name = Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
| HGNCid = 8548
| Symbol = P4HB
| AltSymbols =; DSI; ERBA2L; GIT; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
| OMIM = 176790
| ECnumber =
| Homologene = 55495
| MGIid = 97464
| GeneAtlas_image1 = PBB_GE_P4HB_200656_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_P4HB_200654_at_tn.png
| Function = {{GNF_GO|id=GO:0003756 |text = protein disulfide isomerase activity}} {{GNF_GO|id=GO:0004656 |text = procollagen-proline 4-dioxygenase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015035 |text = protein disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0018401 |text = peptidyl-proline hydroxylation to 4-hydroxy-L-proline}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5034
| Hs_Ensembl = ENSG00000185624
| Hs_RefseqProtein = NP_000909
| Hs_RefseqmRNA = NM_000918
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 77394326
| Hs_GenLoc_end = 77411680
| Hs_Uniprot = P07237
| Mm_EntrezGene = 18453
| Mm_Ensembl = ENSMUSG00000025130
| Mm_RefseqmRNA = NM_011032
| Mm_RefseqProtein = NP_035162
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 120376394
| Mm_GenLoc_end = 120389026
| Mm_Uniprot = Q3TF72
}}
}}
'''Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide''', also known as '''P4HB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P4HB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5034| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.<ref name="entrez">{{cite web | title = Entrez Gene: P4HB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5034| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pihlajaniemi T, Myllylä R, Kivirikko KI |title=Prolyl 4-hydroxylase and its role in collagen synthesis. |journal=J. Hepatol. |volume=13 Suppl 3 |issue= |pages= S2-7 |year= 1992 |pmid= 1667665 |doi= }}
*{{cite journal | author=Wilkinson B, Gilbert HF |title=Protein disulfide isomerase. |journal=Biochim. Biophys. Acta |volume=1699 |issue= 1-2 |pages= 35-44 |year= 2004 |pmid= 15158710 |doi= 10.1016/j.bbapap.2004.02.017 }}
*{{cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi= }}
*{{cite journal | author=Chessler SD, Byers PH |title=Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a deletion in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat pattern. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7751-7 |year= 1992 |pmid= 1339453 |doi= }}
*{{cite journal | author=Vuori K, Myllylä R, Pihlajaniemi T, Kivirikko KI |title=Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7211-4 |year= 1992 |pmid= 1559965 |doi= }}
*{{cite journal | author=Tasanen K, Oikarinen J, Kivirikko KI, Pihlajaniemi T |title=Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 11513-9 |year= 1992 |pmid= 1597478 |doi= }}
*{{cite journal | author=Bauw G, Rasmussen HH, van den Bulcke M, ''et al.'' |title=Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. |journal=Electrophoresis |volume=11 |issue= 7 |pages= 528-36 |year= 1990 |pmid= 1699755 |doi= 10.1002/elps.1150110703 }}
*{{cite journal | author=Ward LD, Hong J, Whitehead RH, Simpson RJ |title=Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis. |journal=Electrophoresis |volume=11 |issue= 10 |pages= 883-91 |year= 1991 |pmid= 2079031 |doi= 10.1002/elps.1150111019 }}
*{{cite journal | author=Tasanen K, Parkkonen T, Chow LT, ''et al.'' |title=Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase. |journal=J. Biol. Chem. |volume=263 |issue= 31 |pages= 16218-24 |year= 1988 |pmid= 2846539 |doi= }}
*{{cite journal | author=Koivu J, Myllylä R, Helaakoski T, ''et al.'' |title=A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase. |journal=J. Biol. Chem. |volume=262 |issue= 14 |pages= 6447-9 |year= 1987 |pmid= 3032969 |doi= }}
*{{cite journal | author=Pihlajaniemi T, Helaakoski T, Tasanen K, ''et al.'' |title=Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. |journal=EMBO J. |volume=6 |issue= 3 |pages= 643-9 |year= 1987 |pmid= 3034602 |doi= }}
*{{cite journal | author=Morris JI, Varandani PT |title=Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase). |journal=Biochim. Biophys. Acta |volume=949 |issue= 2 |pages= 169-80 |year= 1988 |pmid= 3342239 |doi= }}
*{{cite journal | author=Gosden JR, Middleton PG, Rout D, De Angelis C |title=Chromosomal localization of the human oncogene ERBA2. |journal=Cytogenet. Cell Genet. |volume=43 |issue= 3-4 |pages= 150-3 |year= 1987 |pmid= 3467900 |doi= }}
*{{cite journal | author=Cheng SY, Gong QH, Parkison C, ''et al.'' |title=The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum. |journal=J. Biol. Chem. |volume=262 |issue= 23 |pages= 11221-7 |year= 1987 |pmid= 3611107 |doi= }}
*{{cite journal | author=Helaakoski T, Annunen P, Vuori K, ''et al.'' |title=Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 10 |pages= 4427-31 |year= 1995 |pmid= 7753822 |doi= }}
*{{cite journal | author=Shoulders CC, Brett DJ, Bayliss JD, ''et al.'' |title=Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein. |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2109-16 |year= 1994 |pmid= 8111381 |doi= }}
*{{cite journal | author=Kemmink J, Darby NJ, Dijkstra K, ''et al.'' |title=Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase. |journal=Protein Sci. |volume=4 |issue= 12 |pages= 2587-93 |year= 1996 |pmid= 8580850 |doi= }}
*{{cite journal | author=Kemmink J, Darby NJ, Dijkstra K, ''et al.'' |title=Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy. |journal=Biochemistry |volume=35 |issue= 24 |pages= 7684-91 |year= 1996 |pmid= 8672469 |doi= 10.1021/bi960335m }}
*{{cite journal | author=Ji H, Reid GE, Moritz RL, ''et al.'' |title=A two-dimensional gel database of human colon carcinoma proteins. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 605-13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PDE4D... {November 15, 2007 7:18:13 PM PST}
- SEARCH REDIRECT: Control Box Found: PDE4D {November 15, 2007 7:18:41 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:18:42 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:18:42 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:18:42 PM PST}
- UPDATED: Updated protein page: PDE4D {November 15, 2007 7:18:49 PM PST}
- INFO: Beginning work on PLA2G4A... {November 15, 2007 7:18:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:19:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PLA2G4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bci.
| PDB = {{PDB2|1bci}}, {{PDB2|1cjy}}, {{PDB2|1rlw}}
| Name = Phospholipase A2, group IVA (cytosolic, calcium-dependent)
| HGNCid = 9035
| Symbol = PLA2G4A
| AltSymbols =; MGC126350; PLA2G4; cPLA2-alpha
| OMIM = 600522
| ECnumber =
| Homologene = 32059
| MGIid = 1195256
| GeneAtlas_image1 = PBB_GE_PLA2G4A_210145_at_tn.png
| Function = {{GNF_GO|id=GO:0004622 |text = lysophospholipase activity}} {{GNF_GO|id=GO:0004623 |text = phospholipase A2 activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006663 |text = platelet activating factor biosynthetic process}} {{GNF_GO|id=GO:0006690 |text = icosanoid metabolic process}} {{GNF_GO|id=GO:0009395 |text = phospholipid catabolic process}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5321
| Hs_Ensembl = ENSG00000116711
| Hs_RefseqProtein = NP_077734
| Hs_RefseqmRNA = NM_024420
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 185064708
| Hs_GenLoc_end = 185224736
| Hs_Uniprot = P47712
| Mm_EntrezGene = 18783
| Mm_Ensembl = ENSMUSG00000056220
| Mm_RefseqmRNA = NM_008869
| Mm_RefseqProtein = NP_032895
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 151591836
| Mm_GenLoc_end = 151723502
| Mm_Uniprot = Q3UMQ1
}}
}}
'''Phospholipase A2, group IVA (cytosolic, calcium-dependent)''', also known as '''PLA2G4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5321| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.<ref name="entrez">{{cite web | title = Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5321| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dennis EA |title=Diversity of group types, regulation, and function of phospholipase A2. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13057-60 |year= 1994 |pmid= 8175726 |doi= }}
*{{cite journal | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi= }}
*{{cite journal | author=Hirabayashi T, Murayama T, Shimizu T |title=Regulatory mechanism and physiological role of cytosolic phospholipase A2. |journal=Biol. Pharm. Bull. |volume=27 |issue= 8 |pages= 1168-73 |year= 2005 |pmid= 15305015 |doi= }}
*{{cite journal | author=Law MH, Cotton RG, Berger GE |title=The role of phospholipases A2 in schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 547-56 |year= 2006 |pmid= 16585943 |doi= 10.1038/sj.mp.4001819 }}
*{{cite journal | author=Shimizu T, Ohto T, Kita Y |title=Cytosolic phospholipase A2: biochemical properties and physiological roles. |journal=IUBMB Life |volume=58 |issue= 5-6 |pages= 328-33 |year= 2006 |pmid= 16754327 |doi= 10.1080/15216540600702289 }}
*{{cite journal | author=Sharp JD, White DL, Chiou XG, ''et al.'' |title=Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 14850-3 |year= 1991 |pmid= 1869522 |doi= }}
*{{cite journal | author=Clark JD, Lin LL, Kriz RW, ''et al.'' |title=A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. |journal=Cell |volume=65 |issue= 6 |pages= 1043-51 |year= 1991 |pmid= 1904318 |doi= }}
*{{cite journal | author=Tay A, Simon JS, Squire J, ''et al.'' |title=Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. |journal=Genomics |volume=26 |issue= 1 |pages= 138-41 |year= 1995 |pmid= 7782073 |doi= }}
*{{cite journal | author=Wu T, Ikezono T, Angus CW, Shelhamer JH |title=Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene. |journal=Nucleic Acids Res. |volume=22 |issue= 23 |pages= 5093-8 |year= 1995 |pmid= 7800505 |doi= }}
*{{cite journal | author=Miyashita A, Crystal RG, Hay JG |title=Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene. |journal=Nucleic Acids Res. |volume=23 |issue= 2 |pages= 293-301 |year= 1995 |pmid= 7862535 |doi= }}
*{{cite journal | author=Morri H, Ozaki M, Watanabe Y |title=5'-flanking region surrounding a human cytosolic phospholipase A2 gene. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 6-11 |year= 1995 |pmid= 7999086 |doi= }}
*{{cite journal | author=Sharp JD, Pickard RT, Chiou XG, ''et al.'' |title=Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 23250-4 |year= 1994 |pmid= 8083230 |doi= }}
*{{cite journal | author=Lin LL, Wartmann M, Lin AY, ''et al.'' |title=cPLA2 is phosphorylated and activated by MAP kinase. |journal=Cell |volume=72 |issue= 2 |pages= 269-78 |year= 1993 |pmid= 8381049 |doi= }}
*{{cite journal | author=Flati V, Haque SJ, Williams BR |title=Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor three. |journal=EMBO J. |volume=15 |issue= 7 |pages= 1566-71 |year= 1996 |pmid= 8612580 |doi= }}
*{{cite journal | author=de Carvalho MG, McCormack AL, Olson E, ''et al.'' |title=Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6987-97 |year= 1996 |pmid= 8636128 |doi= }}
*{{cite journal | author=Freed KA, Moses EK, Brennecke SP, Rice GE |title=Differential expression of type II, IV and cytosolic PLA2 messenger RNA in human intrauterine tissues at term. |journal=Mol. Hum. Reprod. |volume=3 |issue= 6 |pages= 493-9 |year= 1997 |pmid= 9239738 |doi= }}
*{{cite journal | author=Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, ''et al.'' |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1-9 |year= 1997 |pmid= 9377118 |doi= }}
*{{cite journal | author=Perisic O, Fong S, Lynch DE, ''et al.'' |title=Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1596-604 |year= 1998 |pmid= 9430701 |doi= }}
*{{cite journal | author=Börsch-Haubold AG, Bartoli F, Asselin J, ''et al.'' |title=Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4449-58 |year= 1998 |pmid= 9468497 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRLR... {November 15, 2007 7:19:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:19:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRLR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bp3.
| PDB = {{PDB2|1bp3}}
| Name = Prolactin receptor
| HGNCid = 9446
| Symbol = PRLR
| AltSymbols =; hPRLrI
| OMIM = 176761
| ECnumber =
| Homologene = 733
| MGIid = 97763
| GeneAtlas_image1 = PBB_GE_PRLR_210476_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRLR_216638_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRLR_206346_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004925 |text = prolactin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0042978 |text = ornithine decarboxylase activator activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006694 |text = steroid biosynthetic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007171 |text = transmembrane receptor protein tyrosine kinase activation (dimerization)}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030856 |text = regulation of epithelial cell differentiation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0042977 |text = tyrosine phosphorylation of JAK2 protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5618
| Hs_Ensembl = ENSG00000113494
| Hs_RefseqProtein = NP_000940
| Hs_RefseqmRNA = NM_000949
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 35084621
| Hs_GenLoc_end = 35266334
| Hs_Uniprot = P16471
| Mm_EntrezGene = 19116
| Mm_Ensembl = ENSMUSG00000005268
| Mm_RefseqmRNA = NM_011169
| Mm_RefseqProtein = NP_035299
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 10121963
| Mm_GenLoc_end = 10274098
| Mm_Uniprot = Q8C5N1
}}
}}
'''Prolactin receptor''', also known as '''PRLR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRLR prolactin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5618| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bole-Feysot C, Goffin V, Edery M, ''et al.'' |title=Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. |journal=Endocr. Rev. |volume=19 |issue= 3 |pages= 225-68 |year= 1998 |pmid= 9626554 |doi= }}
*{{cite journal | author=Clevenger CV, Kline JB |title=Prolactin receptor signal transduction. |journal=Lupus |volume=10 |issue= 10 |pages= 706-18 |year= 2002 |pmid= 11721697 |doi= }}
*{{cite journal | author=Rozakis-Adcock M, Kelly PA |title=Identification of ligand binding determinants of the prolactin receptor. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7428-33 |year= 1992 |pmid= 1559983 |doi= }}
*{{cite journal | author=Di Carlo R, Muccioli G, Papotti M, Bussolati G |title=Characterization of prolactin receptor in human brain and choroid plexus. |journal=Brain Res. |volume=570 |issue= 1-2 |pages= 341-6 |year= 1992 |pmid= 1617425 |doi= }}
*{{cite journal | author=Arden KC, Boutin JM, Djiane J, ''et al.'' |title=The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. |journal=Cytogenet. Cell Genet. |volume=53 |issue= 2-3 |pages= 161-5 |year= 1990 |pmid= 2369845 |doi= }}
*{{cite journal | author=Boutin JM, Edery M, Shirota M, ''et al.'' |title=Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells. |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1455-61 |year= 1990 |pmid= 2558309 |doi= }}
*{{cite journal | author=Turcot-Lemay L, Kelly PA |title=Prolactin receptors in human breast tumors. |journal=J. Natl. Cancer Inst. |volume=68 |issue= 3 |pages= 381-3 |year= 1982 |pmid= 6278192 |doi= }}
*{{cite journal | author=Russell DH, Matrisian L, Kibler R, ''et al.'' |title=Prolactin receptors on human lymphocytes and their modulation by cyclosporine. |journal=Biochem. Biophys. Res. Commun. |volume=121 |issue= 3 |pages= 899-906 |year= 1984 |pmid= 6331435 |doi= }}
*{{cite journal | author=Clevenger CV, Chang WP, Ngo W, ''et al.'' |title=Expression of prolactin and prolactin receptor in human breast carcinoma. Evidence for an autocrine/paracrine loop. |journal=Am. J. Pathol. |volume=146 |issue= 3 |pages= 695-705 |year= 1995 |pmid= 7534043 |doi= }}
*{{cite journal | author=Rao YP, Buckley DJ, Olson MD, Buckley AR |title=Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells. |journal=J. Cell. Physiol. |volume=163 |issue= 2 |pages= 266-76 |year= 1995 |pmid= 7706371 |doi= 10.1002/jcp.1041630207 }}
*{{cite journal | author=Fuh G, Wells JA |title=Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13133-7 |year= 1995 |pmid= 7768908 |doi= }}
*{{cite journal | author=Clevenger CV, Ngo W, Sokol DL, ''et al.'' |title=Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13246-53 |year= 1995 |pmid= 7768923 |doi= }}
*{{cite journal | author=Somers W, Ultsch M, De Vos AM, Kossiakoff AA |title=The X-ray structure of a growth hormone-prolactin receptor complex. |journal=Nature |volume=372 |issue= 6505 |pages= 478-81 |year= 1994 |pmid= 7984244 |doi= 10.1038/372478a0 }}
*{{cite journal | author=Maaskant RA, Bogic LV, Gilger S, ''et al.'' |title=The human prolactin receptor in the fetal membranes, decidua, and placenta. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 1 |pages= 396-405 |year= 1996 |pmid= 8550784 |doi= }}
*{{cite journal | author=Ormandy CJ, Camus A, Barra J, ''et al.'' |title=Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. |journal=Genes Dev. |volume=11 |issue= 2 |pages= 167-78 |year= 1997 |pmid= 9009200 |doi= }}
*{{cite journal | author=Pezet A, Buteau H, Kelly PA, Edery M |title=The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 2 |pages= 199-208 |year= 1997 |pmid= 9202403 |doi= }}
*{{cite journal | author=Schwärzler P, Untergasser G, Hermann M, ''et al.'' |title=Prolactin gene expression and prolactin protein in premenopausal and postmenopausal human ovaries. |journal=Fertil. Steril. |volume=68 |issue= 4 |pages= 696-701 |year= 1997 |pmid= 9341613 |doi= }}
*{{cite journal | author=Buteau H, Pezet A, Ferrag F, ''et al.'' |title=N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting. |journal=Mol. Endocrinol. |volume=12 |issue= 4 |pages= 544-55 |year= 1998 |pmid= 9544990 |doi= }}
*{{cite journal | author=Kopchick J, Chen XZ, Li Y, ''et al.'' |title=Differential in vivo activities of bovine growth hormone analogues. |journal=Transgenic Res. |volume=7 |issue= 1 |pages= 61-71 |year= 1998 |pmid= 9556914 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTCH1... {November 15, 2007 7:19:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:20:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Patched homolog 1 (Drosophila)
| HGNCid = 9585
| Symbol = PTCH1
| AltSymbols =; PTC; BCNS; FLJ42602; HPE7; NBCCS; PTC1; PTCH
| OMIM = 601309
| ECnumber =
| Homologene = 223
| MGIid = 105373
| GeneAtlas_image1 = PBB_GE_PTCH1_209815_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTCH1_208522_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTCH1_209816_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005113 |text = patched binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008158 |text = hedgehog receptor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001841 |text = neural tube formation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007224 |text = smoothened signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0040015 |text = negative regulation of body size}} {{GNF_GO|id=GO:0043109 |text = regulation of smoothened activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5727
| Hs_Ensembl = ENSG00000185920
| Hs_RefseqProtein = NP_000255
| Hs_RefseqmRNA = NM_000264
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 97245083
| Hs_GenLoc_end = 97318923
| Hs_Uniprot = Q13635
| Mm_EntrezGene = 19206
| Mm_Ensembl = ENSMUSG00000021466
| Mm_RefseqmRNA = NM_008957
| Mm_RefseqProtein = NP_032983
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 63520755
| Mm_GenLoc_end = 63574742
| Mm_Uniprot = Q3LG17
}}
}}
'''Patched homolog 1 (Drosophila)''', also known as '''PTCH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTCH1 patched homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5727| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene functions as a tumor suppressor. Mutations of this gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.<ref name="entrez">{{cite web | title = Entrez Gene: PTCH1 patched homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5727| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Villavicencio EH, Walterhouse DO, Iannaccone PM |title=The sonic hedgehog-patched-gli pathway in human development and disease. |journal=Am. J. Hum. Genet. |volume=67 |issue= 5 |pages= 1047-54 |year= 2000 |pmid= 11001584 |doi= }}
*{{cite journal | author=Corcoran RB, Scott MP |title=A mouse model for medulloblastoma and basal cell nevus syndrome. |journal=J. Neurooncol. |volume=53 |issue= 3 |pages= 307-18 |year= 2002 |pmid= 11718263 |doi= }}
*{{cite journal | author=Lindström E, Shimokawa T, Toftgård R, Zaphiropoulos PG |title=PTCH mutations: distribution and analyses. |journal=Hum. Mutat. |volume=27 |issue= 3 |pages= 215-9 |year= 2006 |pmid= 16419085 |doi= 10.1002/humu.20296 }}
*{{cite journal | author=Gailani MR, Bale SJ, Leffell DJ, ''et al.'' |title=Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. |journal=Cell |volume=69 |issue= 1 |pages= 111-7 |year= 1992 |pmid= 1348213 |doi= }}
*{{cite journal | author=Hahn H, Christiansen J, Wicking C, ''et al.'' |title=A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12125-8 |year= 1996 |pmid= 8647801 |doi= }}
*{{cite journal | author=Johnson RL, Rothman AL, Xie J, ''et al.'' |title=Human homolog of patched, a candidate gene for the basal cell nevus syndrome. |journal=Science |volume=272 |issue= 5268 |pages= 1668-71 |year= 1996 |pmid= 8658145 |doi= }}
*{{cite journal | author=Hahn H, Wicking C, Zaphiropoulous PG, ''et al.'' |title=Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. |journal=Cell |volume=85 |issue= 6 |pages= 841-51 |year= 1996 |pmid= 8681379 |doi= }}
*{{cite journal | author=Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, ''et al.'' |title=The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. |journal=Nat. Genet. |volume=14 |issue= 1 |pages= 78-81 |year= 1996 |pmid= 8782823 |doi= 10.1038/ng0996-78 }}
*{{cite journal | author=Chidambaram A, Goldstein AM, Gailani MR, ''et al.'' |title=Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients. |journal=Cancer Res. |volume=56 |issue= 20 |pages= 4599-601 |year= 1996 |pmid= 8840969 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Stone DM, Hynes M, Armanini M, ''et al.'' |title=The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. |journal=Nature |volume=384 |issue= 6605 |pages= 129-34 |year= 1996 |pmid= 8906787 |doi= 10.1038/384129a0 }}
*{{cite journal | author=Wicking C, Shanley S, Smyth I, ''et al.'' |title=Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. |journal=Am. J. Hum. Genet. |volume=60 |issue= 1 |pages= 21-6 |year= 1997 |pmid= 8981943 |doi= }}
*{{cite journal | author=Lench NJ, Telford EA, High AS, ''et al.'' |title=Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome. |journal=Hum. Genet. |volume=100 |issue= 5-6 |pages= 497-502 |year= 1997 |pmid= 9341860 |doi= }}
*{{cite journal | author=Aszterbaum M, Rothman A, Johnson RL, ''et al.'' |title=Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. |journal=J. Invest. Dermatol. |volume=110 |issue= 6 |pages= 885-8 |year= 1998 |pmid= 9620294 |doi= 10.1046/j.1523-1747.1998.00222.x }}
*{{cite journal | author=Carpenter D, Stone DM, Brush J, ''et al.'' |title=Characterization of two patched receptors for the vertebrate hedgehog protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13630-4 |year= 1998 |pmid= 9811851 |doi= }}
*{{cite journal | author=Liu JH, Wei S, Burnette PK, ''et al.'' |title=Functional association of TGF-beta receptor II with cyclin B. |journal=Oncogene |volume=18 |issue= 1 |pages= 269-75 |year= 1999 |pmid= 9926943 |doi= 10.1038/sj.onc.1202263 }}
*{{cite journal | author=Hasenpusch-Theil K, Bataille V, Laehdetie J, ''et al.'' |title=Gorlin syndrome: identification of 4 novel germ-line mutations of the human patched (PTCH) gene. Mutations in brief no. 137. Online. |journal=Hum. Mutat. |volume=11 |issue= 6 |pages= 480 |year= 1999 |pmid= 10200051 |doi= 10.1002/(SICI)1098-1004(1998)11:6<480::AID-HUMU9>3.0.CO;2-4 }}
*{{cite journal | author=Dong J, Gailani MR, Pomeroy SL, ''et al.'' |title=Identification of PATCHED mutations in medulloblastomas by direct sequencing. |journal=Hum. Mutat. |volume=16 |issue= 1 |pages= 89-90 |year= 2000 |pmid= 10874314 |doi= 10.1002/1098-1004(200007)16:1<89::AID-HUMU18>3.0.CO;2-7 }}
*{{cite journal | author=Reifenberger J, Arnold N, Kiechle M, ''et al.'' |title=Coincident PTCH and BRCA1 germline mutations in a patient with nevoid basal cell carcinoma syndrome and familial breast cancer. |journal=J. Invest. Dermatol. |volume=116 |issue= 3 |pages= 472-4 |year= 2001 |pmid= 11231326 |doi= 10.1046/j.1523-1747.2001.01279-2.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC9A3R1... {November 15, 2007 7:22:30 PM PST}
- SEARCH REDIRECT: Control Box Found: SLC9A3R1 {November 15, 2007 7:22:55 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 15, 2007 7:22:56 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 15, 2007 7:22:56 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 15, 2007 7:22:56 PM PST}
- UPDATED: Updated protein page: SLC9A3R1 {November 15, 2007 7:23:03 PM PST}
- INFO: Beginning work on TAC1... {November 15, 2007 7:20:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:21:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TAC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b19.
| PDB = {{PDB2|2b19}}
| Name = Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
| HGNCid = 11517
| Symbol = TAC1
| AltSymbols =; Hs.2563; NK2; NKNA; TAC2
| OMIM = 162320
| ECnumber =
| Homologene = 2394
| MGIid = 98474
| GeneAtlas_image1 = PBB_GE_TAC1_206552_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007217 |text = tachykinin signaling pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007320 |text = insemination}} {{GNF_GO|id=GO:0009582 |text = detection of abiotic stimulus}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0048265 |text = response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6863
| Hs_Ensembl = ENSG00000006128
| Hs_RefseqProtein = NP_003173
| Hs_RefseqmRNA = NM_003182
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 97199311
| Hs_GenLoc_end = 97207696
| Hs_Uniprot = P20366
| Mm_EntrezGene = 21333
| Mm_Ensembl = ENSMUSG00000061762
| Mm_RefseqmRNA = XM_984642
| Mm_RefseqProtein = XP_989736
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 7505071
| Mm_GenLoc_end = 7512973
| Mm_Uniprot = Q149W7
}}
}}
'''Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)''', also known as '''TAC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6863| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.<ref name="entrez">{{cite web | title = Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6863| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kowall NW, Quigley BJ, Krause JE, ''et al.'' |title=Substance P and substance P receptor histochemistry in human neurodegenerative diseases. |journal=Regul. Pept. |volume=46 |issue= 1-2 |pages= 174-85 |year= 1993 |pmid= 7692486 |doi= }}
*{{cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892-906 |year= 1997 |pmid= 9272936 |doi= }}
*{{cite journal | author=Rameshwar P, Oh HS, Yook C, ''et al.'' |title=Substance p-fibronectin-cytokine interactions in myeloproliferative disorders with bone marrow fibrosis. |journal=Acta Haematol. |volume=109 |issue= 1 |pages= 1-10 |year= 2003 |pmid= 12486316 |doi= }}
*{{cite journal | author=Saito R, Takano Y, Kamiya HO |title=Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. |journal=J. Pharmacol. Sci. |volume=91 |issue= 2 |pages= 87-94 |year= 2003 |pmid= 12686752 |doi= }}
*{{cite journal | author=Di Angelantonio S, Giniatullin R, Costa V, ''et al.'' |title=Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. |journal=Br. J. Pharmacol. |volume=139 |issue= 6 |pages= 1061-73 |year= 2004 |pmid= 12871824 |doi= 10.1038/sj.bjp.0705337 }}
*{{cite journal | author=Bannon MJ, Poosch MS, Haverstick DM, ''et al.'' |title=Preprotachykinin gene expression in the human basal ganglia: characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing. |journal=Brain Res. Mol. Brain Res. |volume=12 |issue= 1-3 |pages= 225-31 |year= 1992 |pmid= 1312203 |doi= }}
*{{cite journal | author=Chiwakata C, Brackmann B, Hunt N, ''et al.'' |title=Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. |journal=Endocrinology |volume=128 |issue= 5 |pages= 2441-8 |year= 1991 |pmid= 1708336 |doi= }}
*{{cite journal | author=McGregor GP, Conlon JM |title=Characterization of the C-terminal flanking peptide of human beta-preprotachykinin. |journal=Peptides |volume=11 |issue= 5 |pages= 907-10 |year= 1991 |pmid= 2284201 |doi= }}
*{{cite journal | author=Theodorsson-Norheim E, Jörnvall H, Andersson M, ''et al.'' |title=Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. |journal=Eur. J. Biochem. |volume=166 |issue= 3 |pages= 693-7 |year= 1987 |pmid= 3038549 |doi= }}
*{{cite journal | author=Harmar AJ, Armstrong A, Pascall JC, ''et al.'' |title=cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A. |journal=FEBS Lett. |volume=208 |issue= 1 |pages= 67-72 |year= 1986 |pmid= 3770210 |doi= }}
*{{cite journal | author=Bhogal N, Donnelly D, Findlay JB |title=The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27269-74 |year= 1994 |pmid= 7961636 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Tian Y, Wu LH, Oxender DL, Chung FZ |title=The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20250-7 |year= 1996 |pmid= 8702757 |doi= }}
*{{cite journal | author=Tanabe T, Otani H, Zeng XT, ''et al.'' |title=Inhibitory effects of calcitonin gene-related peptide on substance-P-induced superoxide production in human neutrophils. |journal=Eur. J. Pharmacol. |volume=314 |issue= 1-2 |pages= 175-83 |year= 1997 |pmid= 8957234 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Zimmer A, Zimmer AM, Baffi J, ''et al.'' |title=Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2630-5 |year= 1998 |pmid= 9482938 |doi= }}
*{{cite journal | author=Ho WZ, Lai JP, Zhu XH, ''et al.'' |title=Human monocytes and macrophages express substance P and neurokinin-1 receptor. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5654-60 |year= 1998 |pmid= 9548509 |doi= }}
*{{cite journal | author=Lai JP, Douglas SD, Ho WZ |title=Human lymphocytes express substance P and its receptor. |journal=J. Neuroimmunol. |volume=86 |issue= 1 |pages= 80-6 |year= 1998 |pmid= 9655475 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TWIST1... {November 15, 2007 7:21:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:21:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)
| HGNCid = 12428
| Symbol = TWIST1
| AltSymbols =; ACS3; BPES2; BPES3; SCS; TWIST
| OMIM = 601622
| ECnumber =
| Homologene = 402
| MGIid = 98872
| GeneAtlas_image1 = PBB_GE_TWIST1_213943_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0035137 |text = hindlimb morphogenesis}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045843 |text = negative regulation of striated muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7291
| Hs_Ensembl = ENSG00000122691
| Hs_RefseqProtein = NP_000465
| Hs_RefseqmRNA = NM_000474
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 19121633
| Hs_GenLoc_end = 19123820
| Hs_Uniprot = Q15672
| Mm_EntrezGene = 22160
| Mm_Ensembl = ENSMUSG00000035799
| Mm_RefseqmRNA = NM_011658
| Mm_RefseqProtein = NP_035788
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 34542918
| Mm_GenLoc_end = 34545078
| Mm_Uniprot = P26687
}}
}}
'''Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)''', also known as '''TWIST1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7291| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.<ref name="entrez">{{cite web | title = Entrez Gene: TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7291| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Seto ML, Lee SJ, Sze RW, Cunningham ML |title=Another TWIST on Baller-Gerold syndrome. |journal=Am. J. Med. Genet. |volume=104 |issue= 4 |pages= 323-30 |year= 2002 |pmid= 11754069 |doi= }}
*{{cite journal | author=Brueton LA, van Herwerden L, Chotai KA, Winter RM |title=The mapping of a gene for craniosynostosis: evidence for linkage of the Saethre-Chotzen syndrome to distal chromosome 7p. |journal=J. Med. Genet. |volume=29 |issue= 10 |pages= 681-5 |year= 1992 |pmid= 1433226 |doi= }}
*{{cite journal | author=Bianchi DW, Cirillo-Silengo M, Luzzatti L, Greenstein RM |title=Interstitial deletion of the short arm of chromosome 7 without craniosynostosis. |journal=Clin. Genet. |volume=19 |issue= 6 |pages= 456-61 |year= 1982 |pmid= 7296937 |doi= }}
*{{cite journal | author=Rose CS, King AA, Summers D, ''et al.'' |title=Localization of the genetic locus for Saethre-Chotzen syndrome to a 6 cM region of chromosome 7 using four cases with apparently balanced translocations at 7p21.2. |journal=Hum. Mol. Genet. |volume=3 |issue= 8 |pages= 1405-8 |year= 1995 |pmid= 7987323 |doi= }}
*{{cite journal | author=Maw M, Kar B, Biswas J, ''et al.'' |title=Linkage of blepharophimosis syndrome in a large Indian pedigree to chromosome 7p. |journal=Hum. Mol. Genet. |volume=5 |issue= 12 |pages= 2049-54 |year= 1997 |pmid= 8968762 |doi= }}
*{{cite journal | author=Howard TD, Paznekas WA, Green ED, ''et al.'' |title=Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. |journal=Nat. Genet. |volume=15 |issue= 1 |pages= 36-41 |year= 1997 |pmid= 8988166 |doi= 10.1038/ng0197-36 }}
*{{cite journal | author=el Ghouzzi V, Le Merrer M, Perrin-Schmitt F, ''et al.'' |title=Mutations of the TWIST gene in the Saethre-Chotzen syndrome. |journal=Nat. Genet. |volume=15 |issue= 1 |pages= 42-6 |year= 1997 |pmid= 8988167 |doi= 10.1038/ng0197-42 }}
*{{cite journal | author=Bourgeois P, Stoetzel C, Bolcato-Bellemin AL, ''et al.'' |title=The human H-twist gene is located at 7p21 and encodes a B-HLH protein that is 96% similar to its murine M-twist counterpart. |journal=Mamm. Genome |volume=7 |issue= 12 |pages= 915-7 |year= 1997 |pmid= 8995765 |doi= }}
*{{cite journal | author=Wang SM, Coljee VW, Pignolo RJ, ''et al.'' |title=Cloning of the human twist gene: its expression is retained in adult mesodermally-derived tissues. |journal=Gene |volume=187 |issue= 1 |pages= 83-92 |year= 1997 |pmid= 9073070 |doi= }}
*{{cite journal | author=Krebs I, Weis I, Hudler M, ''et al.'' |title=Translocation breakpoint maps 5 kb 3' from TWIST in a patient affected with Saethre-Chotzen syndrome. |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1079-86 |year= 1997 |pmid= 9215678 |doi= }}
*{{cite journal | author=Rose CS, Patel P, Reardon W, ''et al.'' |title=The TWIST gene, although not disrupted in Saethre-Chotzen patients with apparently balanced translocations of 7p21, is mutated in familial and sporadic cases. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1369-73 |year= 1997 |pmid= 9259286 |doi= }}
*{{cite journal | author=Hamamori Y, Wu HY, Sartorelli V, Kedes L |title=The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6563-73 |year= 1997 |pmid= 9343420 |doi= }}
*{{cite journal | author=Gripp KW, Stolle CA, Celle L, ''et al.'' |title=TWIST gene mutation in a patient with radial aplasia and craniosynostosis: further evidence for heterogeneity of Baller-Gerold syndrome. |journal=Am. J. Med. Genet. |volume=82 |issue= 2 |pages= 170-6 |year= 1999 |pmid= 9934984 |doi= }}
*{{cite journal | author=Hamamori Y, Sartorelli V, Ogryzko V, ''et al.'' |title=Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. |journal=Cell |volume=96 |issue= 3 |pages= 405-13 |year= 1999 |pmid= 10025406 |doi= }}
*{{cite journal | author=Kunz J, Hudler M, Fritz B |title=Identification of a frameshift mutation in the gene TWIST in a family affected with Robinow-Sorauf syndrome. |journal=J. Med. Genet. |volume=36 |issue= 8 |pages= 650-2 |year= 1999 |pmid= 10465122 |doi= }}
*{{cite journal | author=Maestro R, Dei Tos AP, Hamamori Y, ''et al.'' |title=Twist is a potential oncogene that inhibits apoptosis. |journal=Genes Dev. |volume=13 |issue= 17 |pages= 2207-17 |year= 1999 |pmid= 10485844 |doi= }}
*{{cite journal | author=El Ghouzzi V, Legeai-Mallet L, Aresta S, ''et al.'' |title=Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location. |journal=Hum. Mol. Genet. |volume=9 |issue= 5 |pages= 813-9 |year= 2000 |pmid= 10749989 |doi= }}
*{{cite journal | author=Lee MS, Lowe G, Flanagan S, ''et al.'' |title=Human Dermo-1 has attributes similar to twist in early bone development. |journal=Bone |volume=27 |issue= 5 |pages= 591-602 |year= 2000 |pmid= 11062344 |doi= }}
*{{cite journal | author=Dollfus H, Kumaramanickavel G, Biswas P, ''et al.'' |title=Identification of a new TWIST mutation (7p21) with variable eyelid manifestations supports locus homogeneity of BPES at 3q22. |journal=J. Med. Genet. |volume=38 |issue= 7 |pages= 470-2 |year= 2001 |pmid= 11474656 |doi= }}
*{{cite journal | author=Elanko N, Sibbring JS, Metcalfe KA, ''et al.'' |title=A survey of TWIST for mutations in craniosynostosis reveals a variable length polyglycine tract in asymptomatic individuals. |journal=Hum. Mutat. |volume=18 |issue= 6 |pages= 535-41 |year= 2002 |pmid= 11748846 |doi= 10.1002/humu.1230 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VCAN... {November 15, 2007 7:12:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:12:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Versican
| HGNCid = 2464
| Symbol = VCAN
| AltSymbols =; CSPG2; DKFZp686K06110; ERVR; PG-M; WGN; WGN1
| OMIM = 118661
| ECnumber =
| Homologene = 3228
| MGIid = 102889
| GeneAtlas_image1 = PBB_GE_VCAN_204620_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VCAN_204619_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_VCAN_211571_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005540 |text = hyaluronic acid binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008037 |text = cell recognition}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1462
| Hs_Ensembl = ENSG00000038427
| Hs_RefseqProtein = NP_004376
| Hs_RefseqmRNA = NM_004385
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 82803339
| Hs_GenLoc_end = 82912737
| Hs_Uniprot = P13611
| Mm_EntrezGene = 13003
| Mm_Ensembl = ENSMUSG00000021614
| Mm_RefseqmRNA = XM_488510
| Mm_RefseqProtein = XP_488510
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 90131260
| Mm_GenLoc_end = 90216522
| Mm_Uniprot = P70267
}}
}}
'''Versican''', also known as '''VCAN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VCAN versican| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1462| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wight TN, Merrilees MJ |title=Proteoglycans in atherosclerosis and restenosis: key roles for versican. |journal=Circ. Res. |volume=94 |issue= 9 |pages= 1158-67 |year= 2004 |pmid= 15142969 |doi= 10.1161/01.RES.0000126921.29919.51 }}
*{{cite journal | author=Kenagy RD, Plaas AH, Wight TN |title=Versican degradation and vascular disease. |journal=Trends Cardiovasc. Med. |volume=16 |issue= 6 |pages= 209-15 |year= 2006 |pmid= 16839865 |doi= 10.1016/j.tcm.2006.03.011 }}
*{{cite journal | author=Perides G, Rahemtulla F, Lane WS, ''et al.'' |title=Isolation of a large aggregating proteoglycan from human brain. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23883-7 |year= 1992 |pmid= 1429726 |doi= }}
*{{cite journal | author=Iozzo RV, Naso MF, Cannizzaro LA, ''et al.'' |title=Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). |journal=Genomics |volume=14 |issue= 4 |pages= 845-51 |year= 1993 |pmid= 1478664 |doi= }}
*{{cite journal | author=Perides G, Lane WS, Andrews D, ''et al.'' |title=Isolation and partial characterization of a glial hyaluronate-binding protein. |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5981-7 |year= 1989 |pmid= 2466833 |doi= }}
*{{cite journal | author=Bignami A, Lane WS, Andrews D, Dahl D |title=Structural similarity of hyaluronate binding proteins in brain and cartilage. |journal=Brain Res. Bull. |volume=22 |issue= 1 |pages= 67-70 |year= 1989 |pmid= 2469524 |doi= }}
*{{cite journal | author=Zimmermann DR, Ruoslahti E |title=Multiple domains of the large fibroblast proteoglycan, versican. |journal=EMBO J. |volume=8 |issue= 10 |pages= 2975-81 |year= 1990 |pmid= 2583089 |doi= }}
*{{cite journal | author=Krusius T, Gehlsen KR, Ruoslahti E |title=A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences. |journal=J. Biol. Chem. |volume=262 |issue= 27 |pages= 13120-5 |year= 1987 |pmid= 2820964 |doi= }}
*{{cite journal | author=Naso MF, Zimmermann DR, Iozzo RV |title=Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. |journal=J. Biol. Chem. |volume=269 |issue= 52 |pages= 32999-3008 |year= 1995 |pmid= 7528742 |doi= }}
*{{cite journal | author=Brown DM, Graemiger RA, Hergersberg M, ''et al.'' |title=Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14. |journal=Arch. Ophthalmol. |volume=113 |issue= 5 |pages= 671-5 |year= 1995 |pmid= 7748141 |doi= }}
*{{cite journal | author=Dours-Zimmermann MT, Zimmermann DR |title=A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican. |journal=J. Biol. Chem. |volume=269 |issue= 52 |pages= 32992-8 |year= 1995 |pmid= 7806529 |doi= }}
*{{cite journal | author=Zako M, Shinomura T, Ujita M, ''et al.'' |title=Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3914-8 |year= 1995 |pmid= 7876137 |doi= }}
*{{cite journal | author=Yao LY, Moody C, Schönherr E, ''et al.'' |title=Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry. |journal=Matrix Biol. |volume=14 |issue= 3 |pages= 213-25 |year= 1994 |pmid= 7921538 |doi= }}
*{{cite journal | author=Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF, ''et al.'' |title=Distribution of the large aggregating proteoglycan versican in adult human tissues. |journal=J. Histochem. Cytochem. |volume=44 |issue= 4 |pages= 303-12 |year= 1996 |pmid= 8601689 |doi= }}
*{{cite journal | author=Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR |title=Differential expression of versican isoforms in brain tumors. |journal=J. Neuropathol. Exp. Neurol. |volume=55 |issue= 5 |pages= 528-33 |year= 1996 |pmid= 8627343 |doi= }}
*{{cite journal | author=Sartipy P, Johansen B, Camejo G, ''et al.'' |title=Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity. |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 26307-14 |year= 1996 |pmid= 8824283 |doi= }}
*{{cite journal | author=Aspberg A, Miura R, Bourdoulous S, ''et al.'' |title=The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 19 |pages= 10116-21 |year= 1997 |pmid= 9294172 |doi= }}
*{{cite journal | author=Sartipy P, Bondjers G, Hurt-Camejo E |title=Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=18 |issue= 12 |pages= 1934-41 |year= 1999 |pmid= 9848887 |doi= }}
*{{cite journal | author=Perveen R, Hart-Holden N, Dixon MJ, ''et al.'' |title=Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3. |journal=Genomics |volume=57 |issue= 2 |pages= 219-26 |year= 1999 |pmid= 10198161 |doi= 10.1006/geno.1999.5766 }}
*{{cite journal | author=Lemire JM, Braun KR, Maurel P, ''et al.'' |title=Versican/PG-M isoforms in vascular smooth muscle cells. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=19 |issue= 7 |pages= 1630-9 |year= 1999 |pmid= 10397680 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VDAC1... {November 15, 2007 7:21:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 15, 2007 7:21:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Voltage-dependent anion channel 1
| HGNCid = 12669
| Symbol = VDAC1
| AltSymbols =; MGC111064; PORIN; PORIN-31-HL
| OMIM = 604492
| ECnumber =
| Homologene = 36115
| MGIid = 106919
| GeneAtlas_image1 = PBB_GE_VDAC1_212038_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VDAC1_217140_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008308 |text = voltage-gated ion-selective channel activity}} {{GNF_GO|id=GO:0015283 |text = apoptogenic cytochrome c release channel activity}} {{GNF_GO|id=GO:0015482 |text = voltage-gated anion channel porin activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0006820 |text = anion transport}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7416
| Hs_Ensembl = ENSG00000073905
| Hs_RefseqProtein = NP_003365
| Hs_RefseqmRNA = NM_003374
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 133335506
| Hs_GenLoc_end = 133368723
| Hs_Uniprot = P21796
| Mm_EntrezGene = 22333
| Mm_Ensembl = ENSMUSG00000020402
| Mm_RefseqmRNA = NM_011694
| Mm_RefseqProtein = NP_035824
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 52204283
| Mm_GenLoc_end = 52232820
| Mm_Uniprot = Q3THL7
}}
}}
'''Voltage-dependent anion channel 1''', also known as '''VDAC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VDAC1 voltage-dependent anion channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7416| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Verrier F, Mignotte B, Jan G, Brenner C |title=Study of PTPC composition during apoptosis for identification of viral protein target. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 126-42 |year= 2004 |pmid= 15033708 |doi= }}
*{{cite journal | author=McEnery MW, Snowman AM, Trifiletti RR, Snyder SH |title=Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3170-4 |year= 1992 |pmid= 1373486 |doi= }}
*{{cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
*{{cite journal | author=Jürgens L, Ilsemann P, Kratzin HD, ''et al.'' |title=Studies on human porin. IV. The primary structures of "Porin 31HM" purified from human skeletal muscle membranes and of "Porin 31HL" derived from human B lymphocyte membranes are identical. |journal=Biol. Chem. Hoppe-Seyler |volume=372 |issue= 7 |pages= 455-63 |year= 1991 |pmid= 1657034 |doi= }}
*{{cite journal | author=Kayser H, Kratzin HD, Thinnes FP, ''et al.'' |title=[Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL).] |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 12 |pages= 1265-78 |year= 1990 |pmid= 2559745 |doi= }}
*{{cite journal | author=Blachly-Dyson E, Baldini A, Litt M, ''et al.'' |title=Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. |journal=Genomics |volume=20 |issue= 1 |pages= 62-7 |year= 1994 |pmid= 7517385 |doi= 10.1006/geno.1994.1127 }}
*{{cite journal | author=Brdiczka D, Kaldis P, Wallimann T |title=In vitro complex formation between the octamer of mitochondrial creatine kinase and porin. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27640-4 |year= 1994 |pmid= 7525559 |doi= }}
*{{cite journal | author=Yu WH, Wolfgang W, Forte M |title=Subcellular localization of human voltage-dependent anion channel isoforms. |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13998-4006 |year= 1995 |pmid= 7539795 |doi= }}
*{{cite journal | author=Thomas L, Blachly-Dyson E, Colombini M, Forte M |title=Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5446-9 |year= 1993 |pmid= 7685903 |doi= }}
*{{cite journal | author=Blachly-Dyson E, Zambronicz EB, Yu WH, ''et al.'' |title=Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 1835-41 |year= 1993 |pmid= 8420959 |doi= }}
*{{cite journal | author=Schleiff E, Shore GC, Goping IS |title=Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins. |journal=FEBS Lett. |volume=404 |issue= 2-3 |pages= 314-8 |year= 1997 |pmid= 9119086 |doi= }}
*{{cite journal | author=Reymann S, Haase W, Krick W, ''et al.'' |title=Endosomes: another extra-mitochondrial location of type-1 porin/voltage-dependent anion-selective channels. |journal=Pflugers Arch. |volume=436 |issue= 3 |pages= 478-80 |year= 1998 |pmid= 9644232 |doi= }}
*{{cite journal | author=Narita M, Shimizu S, Ito T, ''et al.'' |title=Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14681-6 |year= 1999 |pmid= 9843949 |doi= }}
*{{cite journal | author=Crompton M, Virji S, Ward JM |title=Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 729-35 |year= 1999 |pmid= 9874241 |doi= }}
*{{cite journal | author=Messina A, Oliva M, Rosato C, ''et al.'' |title=Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 3 |pages= 707-10 |year= 1999 |pmid= 10049775 |doi= 10.1006/bbrc.1998.0136 }}
*{{cite journal | author=Shimizu S, Narita M, Tsujimoto Y |title=Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. |journal=Nature |volume=399 |issue= 6735 |pages= 483-7 |year= 1999 |pmid= 10365962 |doi= 10.1038/20959 }}
*{{cite journal | author=Decker WK, Bowles KR, Schatte EC, ''et al.'' |title=Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis. |journal=Mamm. Genome |volume=10 |issue= 10 |pages= 1041-2 |year= 2000 |pmid= 10501981 |doi= }}
*{{cite journal | author=Jacotot E, Ravagnan L, Loeffler M, ''et al.'' |title=The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. |journal=J. Exp. Med. |volume=191 |issue= 1 |pages= 33-46 |year= 2000 |pmid= 10620603 |doi= }}
*{{cite journal | author=Shimizu S, Tsujimoto Y |title=Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 2 |pages= 577-82 |year= 2000 |pmid= 10639121 |doi= }}
*{{cite journal | author=Stadtmüller U, Eben-Brunnen J, Schmid A, ''et al.'' |title=Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation. |journal=Biol. Chem. |volume=380 |issue= 12 |pages= 1461-6 |year= 2000 |pmid= 10661876 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
