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Log file for Protein Box Bot

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Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 22:25, 15 December 2007 (UTC)

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Proteins without matches (1)

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RPGR

Redirected Proteins (23)

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TGFBI IFNB1 RPS6KB1 ITGB4 CTSD
EPHA2 COL4A3 COL4A1 TGFB2 RBL1
CTSL1 CD81 VCP SPTA1 CEACAM1
IFNA1 IGFBP1 RPS6KA3 APAF1 S100A9
S100A8 ATF2 GRIN1

Created (18)

[edit]
TGFBI IFNB1 RPS6KB1 ITGB4 CTSD
COL4A3 CTSL1 CD81 VCP SPTA1
CEACAM1 IFNA1 IGFBP1 RPS6KA3 APAF1
S100A9 ATF2 GRIN1

Manual Inspection (Page not found) (1)

[edit]
RPGR

Updated with Warning (1)

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TGFB2

Updated (4)

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EPHA2 COL4A1 RBL1 S100A8


Protein Status Grid - Date: 22:25, 15 December 2007 (UTC)

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HUGO Symbol Action Summary Target page(s) WP Symbol Search
TGFBI Created Location: TGFBI; [1]
IFNB1 Created Location: IFNB1; [2]
RPS6KB1 Created Location: RPS6KB1; [3]
ITGB4 Created Location: ITGB4; [4]
CTSD Created Location: CTSD; [5]
EPHA2 Updated Location: EPH receptor A2; [6]
COL4A3 Created Location: COL4A3 (gene); [7]
COL4A1 Updated Location: COL4A1; [8]
TGFB2 Updated with Warning Location: TGF beta 2; [9]
RBL1 Updated Location: Retinoblastoma-like protein 1; [10]
CTSL1 Created Location: CTSL1; [11]
CD81 Created Location: CD81 (gene); [12]
VCP Created Location: VCP (gene); [13]
SPTA1 Created Location: SPTA1; [14]
CEACAM1 Created Location: CEACAM1; [15]
IFNA1 Created Location: IFNA1; [16]
IGFBP1 Created Location: IGFBP1; [17]
RPS6KA3 Created Location: RPS6KA3; [18]
APAF1 Created Location: APAF1; [19]
S100A9 Created Location: S100A9; [20]
RPGR Manual Inspection (Page not found) Other Pages: Retinitis pigmentosa GTPase regulator (Unknown Data); RPGR (Redirect -> Retinitis pigmentosa GTPase regulator); CRD (DisAmbig); Crd (No Data); COD1 (No Data); Cod1 (No Data); CORDX1 (No Data); Cordx1 (No Data); PCDX (No Data); Pcdx (No Data); RP15 (No Data); Rp15 (No Data); RP3 (Redirect -> RP-3); Rp3 (No Data); XLRP3 (No Data); Xlrp3 (No Data); Orf15 (No Data); RP-3 (Unknown Data); [21]
S100A8 Updated Location: S100 calcium binding protein A8; [22]
ATF2 Created Location: ATF2 (gene); [23]
GRIN1 Created Location: GRIN1; [24]

Vebose Log - Date: 22:25, 15 December 2007 (UTC)

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APAF1

[edit]
  • INFO: Beginning work on APAF1... {December 15, 2007 2:08:52 PM PST}
  • REDIRECT: Protein Redirected to: APAF1 {December 15, 2007 2:09:17 PM PST}
  • CREATED: Created new protein page: APAF1 {December 15, 2007 2:09:28 PM PST}

ATF2

[edit]
  • INFO: Beginning work on ATF2... {December 15, 2007 2:12:10 PM PST}
  • REDIRECT: Protein Redirected to: ATF2 (gene) {December 15, 2007 2:12:35 PM PST}
  • CREATED: Created new protein page: ATF2 (gene) {December 15, 2007 2:12:46 PM PST}

CD81

[edit]
  • INFO: Beginning work on CD81... {December 15, 2007 2:10:07 PM PST}
  • REDIRECT: Protein Redirected to: CD81 (gene) {December 15, 2007 2:10:31 PM PST}
  • CREATED: Created new protein page: CD81 (gene) {December 15, 2007 2:10:43 PM PST}

CEACAM1

[edit]
  • INFO: Beginning work on CEACAM1... {December 15, 2007 2:09:28 PM PST}
  • REDIRECT: Protein Redirected to: CEACAM1 {December 15, 2007 2:09:56 PM PST}
  • CREATED: Created new protein page: CEACAM1 {December 15, 2007 2:10:07 PM PST}

COL4A1

[edit]
  • INFO: Beginning work on COL4A1... {December 15, 2007 2:10:43 PM PST}
  • REDIRECT: Protein Redirected to: COL4A1 {December 15, 2007 2:11:15 PM PST}
  • UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 15, 2007 2:11:18 PM PST}
  • UPDATE SUMMARY: Updating Summary, No Errors. {December 15, 2007 2:11:18 PM PST}
  • UPDATE CITATIONS: Updating Citations, No Errors. {December 15, 2007 2:11:18 PM PST}
  • UPDATED: Updated protein page: COL4A1 {December 15, 2007 2:11:28 PM PST}

COL4A3

[edit]
  • INFO: Beginning work on COL4A3... {December 15, 2007 2:11:28 PM PST}
  • REDIRECT: Protein Redirected to: COL4A3 (gene) {December 15, 2007 2:12:00 PM PST}
  • CREATED: Created new protein page: COL4A3 (gene) {December 15, 2007 2:12:10 PM PST}

CTSD

[edit]
  • INFO: Beginning work on CTSD... {December 15, 2007 2:12:46 PM PST}
  • REDIRECT: Protein Redirected to: CTSD {December 15, 2007 2:13:10 PM PST}
  • CREATED: Created new protein page: CTSD {December 15, 2007 2:13:32 PM PST}

CTSL1

[edit]
  • INFO: Beginning work on CTSL1... {December 15, 2007 2:13:32 PM PST}
  • REDIRECT: Protein Redirected to: CTSL1 {December 15, 2007 2:13:52 PM PST}
  • CREATED: Created new protein page: CTSL1 {December 15, 2007 2:14:03 PM PST}

EPHA2

[edit]
  • INFO: Beginning work on EPHA2... {December 15, 2007 2:14:03 PM PST}
  • REDIRECT: Protein Redirected to: EPH receptor A2 {December 15, 2007 2:14:22 PM PST}
  • UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 15, 2007 2:14:24 PM PST}
  • UPDATE SUMMARY: Updating Summary, No Errors. {December 15, 2007 2:14:24 PM PST}
  • UPDATE CITATIONS: Updating Citations, No Errors. {December 15, 2007 2:14:24 PM PST}
  • UPDATED: Updated protein page: EPH receptor A2 {December 15, 2007 2:14:31 PM PST}

GRIN1

[edit]
  • INFO: Beginning work on GRIN1... {December 15, 2007 2:14:31 PM PST}
  • REDIRECT: Protein Redirected to: GRIN1 {December 15, 2007 2:15:05 PM PST}
  • CREATED: Created new protein page: GRIN1 {December 15, 2007 2:15:29 PM PST}

IFNA1

[edit]
  • INFO: Beginning work on IFNA1... {December 15, 2007 2:15:29 PM PST}
  • REDIRECT: Protein Redirected to: IFNA1 {December 15, 2007 2:15:53 PM PST}
  • CREATED: Created new protein page: IFNA1 {December 15, 2007 2:16:03 PM PST}

IFNB1

[edit]
  • INFO: Beginning work on IFNB1... {December 15, 2007 2:16:03 PM PST}
  • REDIRECT: Protein Redirected to: IFNB1 {December 15, 2007 2:16:23 PM PST}
  • CREATED: Created new protein page: IFNB1 {December 15, 2007 2:16:32 PM PST}

IGFBP1

[edit]
  • INFO: Beginning work on IGFBP1... {December 15, 2007 2:16:32 PM PST}
  • REDIRECT: Protein Redirected to: IGFBP1 {December 15, 2007 2:17:33 PM PST}
  • CREATED: Created new protein page: IGFBP1 {December 15, 2007 2:17:44 PM PST}

ITGB4

[edit]
  • INFO: Beginning work on ITGB4... {December 15, 2007 2:17:44 PM PST}
  • REDIRECT: Protein Redirected to: ITGB4 {December 15, 2007 2:18:19 PM PST}
  • CREATED: Created new protein page: ITGB4 {December 15, 2007 2:18:29 PM PST}

RBL1

[edit]
  • INFO: Beginning work on RBL1... {December 15, 2007 2:18:29 PM PST}
  • REDIRECT: Protein Redirected to: Retinoblastoma-like protein 1 {December 15, 2007 2:19:02 PM PST}
  • UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 15, 2007 2:19:06 PM PST}
  • UPDATE SUMMARY: Updating Summary, No Errors. {December 15, 2007 2:19:06 PM PST}
  • UPDATE CITATIONS: Updating Citations, No Errors. {December 15, 2007 2:19:06 PM PST}
  • UPDATED: Updated protein page: Retinoblastoma-like protein 1 {December 15, 2007 2:19:16 PM PST}

RPGR

[edit]
  • INFO: Beginning work on RPGR... {December 15, 2007 2:19:16 PM PST}
  • REDIRECT: Page directory gave bad page (RPGR). Continuing with search.. Please correct entry: <6103,RPGR>. {December 15, 2007 2:19:35 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {December 15, 2007 2:20:00 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Retinitis pigmentosa GTPase regulator
 | HGNCid = 10295
 | Symbol = RPGR
 | AltSymbols =; CRD; COD1; CORDX1; PCDX; RP15; RP3; XLRP3; orf15
 | OMIM = 312610
 | ECnumber =  
 | Homologene = 55455
 | MGIid = 1344037
 | GeneAtlas_image1 = PBB_GE_RPGR_207624_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} 
 | Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6103
    | Hs_Ensembl = ENSG00000156313
    | Hs_RefseqProtein = NP_000319
    | Hs_RefseqmRNA = NM_000328
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 38013368
    | Hs_GenLoc_end = 38071732
    | Hs_Uniprot = Q92834
    | Mm_EntrezGene = 19893
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_011285
    | Mm_RefseqProtein = NP_035415
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Retinitis pigmentosa GTPase regulator''', also known as '''RPGR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPGR retinitis pigmentosa GTPase regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6103| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RPGR retinitis pigmentosa GTPase regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6103| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Jin ZB, Hayakawa M, Murakami A, Nao-i N |title=RCC1-like domain and ORF15: essentials in RPGR gene. |journal=Adv. Exp. Med. Biol. |volume=572 |issue=  |pages= 29-33 |year= 2007 |pmid= 17249551 |doi=  }}
*{{cite journal  | author=Ott J, Bhattacharya S, Chen JD, ''et al.'' |title=Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 2 |pages= 701-4 |year= 1990 |pmid= 2300556 |doi=  }}
*{{cite journal  | author=McGuire RE, Sullivan LS, Blanton SH, ''et al.'' |title=X-linked dominant cone-rod degeneration: linkage mapping of a new locus for retinitis pigmentosa (RP 15) to Xp22.13-p22.11. |journal=Am. J. Hum. Genet. |volume=57 |issue= 1 |pages= 87-94 |year= 1995 |pmid= 7611300 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Meindl A, Dry K, Herrmann K, ''et al.'' |title=A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange factor is mutated in X-linked retinitis pigmentosa (RP3). |journal=Nat. Genet. |volume=13 |issue= 1 |pages= 35-42 |year= 1996 |pmid= 8673101 |doi= 10.1038/ng0596-35 }}
*{{cite journal  | author=Roepman R, van Duijnhoven G, Rosenberg T, ''et al.'' |title=Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1. |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 1035-41 |year= 1997 |pmid= 8817343 |doi=  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Fujita R, Buraczynska M, Gieser L, ''et al.'' |title=Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: paucity of mutations in the coding region but splice defects in two families. |journal=Am. J. Hum. Genet. |volume=61 |issue= 3 |pages= 571-80 |year= 1997 |pmid= 9326322 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Buraczynska M, Wu W, Fujita R, ''et al.'' |title=Spectrum of mutations in the RPGR gene that are identified in 20% of families with X-linked retinitis pigmentosa. |journal=Am. J. Hum. Genet. |volume=61 |issue= 6 |pages= 1287-92 |year= 1998 |pmid= 9399904 |doi=  }}
*{{cite journal  | author=Hardcastle AJ, David-Gray ZK, Jay M, ''et al.'' |title=Localization of CSNBX (CSNB4) between the retinitis pigmentosa loci RP2 and RP3 on proximal Xp. |journal=Invest. Ophthalmol. Vis. Sci. |volume=38 |issue= 13 |pages= 2750-5 |year= 1998 |pmid= 9418727 |doi=  }}
*{{cite journal  | author=Yan D, Swain PK, Breuer D, ''et al.'' |title=Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19656-63 |year= 1998 |pmid= 9677393 |doi=  }}
*{{cite journal  | author=Fishman GA, Grover S, Jacobson SG, ''et al.'' |title=X-linked retinitis pigmentosa in two families with a missense mutation in the RPGR gene and putative change of glycine to valine at codon 60. |journal=Ophthalmology |volume=105 |issue= 12 |pages= 2286-96 |year= 1998 |pmid= 9855162 |doi= 10.1016/S0161-6420(98)91231-3 }}
*{{cite journal  | author=Linari M, Ueffing M, Manson F, ''et al.'' |title=The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 4 |pages= 1315-20 |year= 1999 |pmid= 9990021 |doi=  }}
*{{cite journal  | author=Dry KL, Manson FD, Lennon A, ''et al.'' |title=Identification of a 5' splice site mutation in the RPGR gene in a family with X-linked retinitis pigmentosa (RP3). |journal=Hum. Mutat. |volume=13 |issue= 2 |pages= 141-5 |year= 1999 |pmid= 10094550 |doi= 10.1002/(SICI)1098-1004(1999)13:2<141::AID-HUMU6>3.0.CO;2-Q }}
*{{cite journal  | author=Kirschner R, Rosenberg T, Schultz-Heienbrok R, ''et al.'' |title=RPGR transcription studies in mouse and human tissues reveal a retina-specific isoform that is disrupted in a patient with X-linked retinitis pigmentosa. |journal=Hum. Mol. Genet. |volume=8 |issue= 8 |pages= 1571-8 |year= 1999 |pmid= 10401007 |doi=  }}
*{{cite journal  | author=Zito I, Thiselton DL, Gorin MB, ''et al.'' |title=Identification of novel RPGR (retinitis pigmentosa GTPase regulator) mutations in a subset of X-linked retinitis pigmentosa families segregating with the RP3 locus. |journal=Hum. Genet. |volume=105 |issue= 1-2 |pages= 57-62 |year= 1999 |pmid= 10480356 |doi=  }}
*{{cite journal  | author=Miano MG, Testa F, Strazzullo M, ''et al.'' |title=Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa. |journal=Eur. J. Hum. Genet. |volume=7 |issue= 6 |pages= 687-94 |year= 1999 |pmid= 10482958 |doi= 10.1038/sj.ejhg.5200352 }}
*{{cite journal  | author=Hong DH, Pawlyk BS, Shang J, ''et al.'' |title=A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3649-54 |year= 2000 |pmid= 10725384 |doi= 10.1073/pnas.060037497 }}
*{{cite journal  | author=Zito I, Gorin MB, Plant C, ''et al.'' |title=Novel mutations of the RPGR gene in RP3 families. |journal=Hum. Mutat. |volume=15 |issue= 4 |pages= 386 |year= 2000 |pmid= 10737996 |doi= 10.1002/(SICI)1098-1004(200004)15:4<386::AID-HUMU23>3.0.CO;2-4 }}
}}
{{refend}}

{{protein-stub}}

RPS6KA3

[edit]
  • INFO: Beginning work on RPS6KA3... {December 15, 2007 2:20:00 PM PST}
  • REDIRECT: Protein Redirected to: RPS6KA3 {December 15, 2007 2:20:32 PM PST}
  • CREATED: Created new protein page: RPS6KA3 {December 15, 2007 2:20:44 PM PST}

RPS6KB1

[edit]
  • INFO: Beginning work on RPS6KB1... {December 15, 2007 2:20:44 PM PST}
  • REDIRECT: Protein Redirected to: RPS6KB1 {December 15, 2007 2:21:19 PM PST}
  • CREATED: Created new protein page: RPS6KB1 {December 15, 2007 2:21:30 PM PST}

S100A8

[edit]
  • INFO: Beginning work on S100A8... {December 15, 2007 2:21:30 PM PST}
  • REDIRECT: Protein Redirected to: S100 calcium binding protein A8 {December 15, 2007 2:21:50 PM PST}
  • UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 15, 2007 2:21:52 PM PST}
  • UPDATE SUMMARY: Updating Summary, No Errors. {December 15, 2007 2:21:52 PM PST}
  • UPDATE CITATIONS: Updating Citations, No Errors. {December 15, 2007 2:21:52 PM PST}
  • UPDATED: Updated protein page: S100 calcium binding protein A8 {December 15, 2007 2:21:59 PM PST}

S100A9

[edit]
  • INFO: Beginning work on S100A9... {December 15, 2007 2:21:59 PM PST}
  • REDIRECT: Protein Redirected to: S100A9 {December 15, 2007 2:22:17 PM PST}
  • CREATED: Created new protein page: S100A9 {December 15, 2007 2:22:28 PM PST}

SPTA1

[edit]
  • INFO: Beginning work on SPTA1... {December 15, 2007 2:22:28 PM PST}
  • REDIRECT: Protein Redirected to: SPTA1 {December 15, 2007 2:22:50 PM PST}
  • CREATED: Created new protein page: SPTA1 {December 15, 2007 2:23:00 PM PST}

TGFB2

[edit]
  • INFO: Beginning work on TGFB2... {December 15, 2007 2:23:00 PM PST}
  • REDIRECT: Protein Redirected to: TGF beta 2 {December 15, 2007 2:23:32 PM PST}
  • UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 15, 2007 2:23:34 PM PST}
  • SKIP SUMMARY: SKIPPING Summary, No Errors. {December 15, 2007 2:23:34 PM PST}
  • UPDATE CITATIONS: Updating Citations, No Errors. {December 15, 2007 2:23:34 PM PST}
  • UPDATED: Warning while updating page: Could not find summary box. {December 15, 2007 2:23:42 PM PST}
  • UPDATED: Updated protein page (with warnings): TGF beta 2 {December 15, 2007 2:23:42 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_TGFB2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tfg.
 | PDB = {{PDB2|1tfg}}, {{PDB2|2tgi}}
 | Name = Transforming growth factor, beta 2
 | HGNCid = 11768
 | Symbol = TGFB2
 | AltSymbols =; MGC116892; TGF-beta2
 | OMIM = 190220
 | ECnumber =  
 | Homologene = 2432
 | MGIid = 98726
 | GeneAtlas_image1 = PBB_GE_TGFB2_209908_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_TGFB2_209909_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_TGFB2_220407_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0001540 |text = beta-amyloid binding}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005160 |text = transforming growth factor beta receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0043025 |text = cell soma}} 
 | Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0010002 |text = cardioblast differentiation}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030307 |text = positive regulation of cell growth}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0031069 |text = hair follicle morphogenesis}} {{GNF_GO|id=GO:0042060 |text = wound healing}} {{GNF_GO|id=GO:0042416 |text = dopamine biosynthetic process}} {{GNF_GO|id=GO:0042637 |text = catagen}} {{GNF_GO|id=GO:0043525 |text = positive regulation of neuron apoptosis}} {{GNF_GO|id=GO:0045617 |text = negative regulation of keratinocyte differentiation}} {{GNF_GO|id=GO:0045787 |text = positive regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045823 |text = positive regulation of heart contraction}} {{GNF_GO|id=GO:0048103 |text = somatic stem cell division}} {{GNF_GO|id=GO:0048666 |text = neuron development}} {{GNF_GO|id=GO:0048699 |text = generation of neurons}} {{GNF_GO|id=GO:0050777 |text = negative regulation of immune response}} {{GNF_GO|id=GO:0050778 |text = positive regulation of immune response}} {{GNF_GO|id=GO:0051795 |text = positive regulation of catagen}} {{GNF_GO|id=GO:0051891 |text = positive regulation of cardioblast differentiation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7042
    | Hs_Ensembl = ENSG00000092969
    | Hs_RefseqProtein = NP_003229
    | Hs_RefseqmRNA = NM_003238
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 216586200
    | Hs_GenLoc_end = 216684584
    | Hs_Uniprot = P61812
    | Mm_EntrezGene = 21808
    | Mm_Ensembl = ENSMUSG00000039239
    | Mm_RefseqmRNA = NM_009367
    | Mm_RefseqProtein = NP_033393
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 188324430
    | Mm_GenLoc_end = 188406777
    | Mm_Uniprot = Q3TWH5
  }}
}}
'''Transforming growth factor, beta 2''', also known as '''TGFB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TGFB2 transforming growth factor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7042| accessdate = }}</ref>

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==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Clark DA, Coker R |title=Transforming growth factor-beta (TGF-beta). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 3 |pages= 293-8 |year= 1998 |pmid= 9611771 |doi=  }}
*{{cite journal  | author=Wick W, Platten M, Weller M |title=Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. |journal=J. Neurooncol. |volume=53 |issue= 2 |pages= 177-85 |year= 2002 |pmid= 11716069 |doi=  }}
*{{cite journal  | author=Bissell DM |title=Chronic liver injury, TGF-beta, and cancer. |journal=Exp. Mol. Med. |volume=33 |issue= 4 |pages= 179-90 |year= 2002 |pmid= 11795478 |doi=  }}
*{{cite journal  | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
*{{cite journal  | author=Daopin S, Piez KA, Ogawa Y, Davies DR |title=Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. |journal=Science |volume=257 |issue= 5068 |pages= 369-73 |year= 1992 |pmid= 1631557 |doi=  }}
*{{cite journal  | author=Schlunegger MP, Grütter MG |title=An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. |journal=Nature |volume=358 |issue= 6385 |pages= 430-4 |year= 1992 |pmid= 1641027 |doi= 10.1038/358430a0 }}
*{{cite journal  | author=Noma T, Glick AB, Geiser AG, ''et al.'' |title=Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter. |journal=Growth Factors |volume=4 |issue= 4 |pages= 247-55 |year= 1992 |pmid= 1764261 |doi=  }}
*{{cite journal  | author=Bodmer S, Podlisny MB, Selkoe DJ, ''et al.'' |title=Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease. |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 2 |pages= 890-7 |year= 1990 |pmid= 2119582 |doi=  }}
*{{cite journal  | author=Webb NR, Madisen L, Rose TM, Purchio AF |title=Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing. |journal=DNA |volume=7 |issue= 7 |pages= 493-7 |year= 1989 |pmid= 2850146 |doi=  }}
*{{cite journal  | author=Madisen L, Webb NR, Rose TM, ''et al.'' |title=Transforming growth factor-beta 2: cDNA cloning and sequence analysis. |journal=DNA |volume=7 |issue= 1 |pages= 1-8 |year= 1988 |pmid= 3162414 |doi=  }}
*{{cite journal  | author=Barton DE, Foellmer BE, Du J, ''et al.'' |title=Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. |journal=Oncogene Res. |volume=3 |issue= 4 |pages= 323-31 |year= 1989 |pmid= 3226728 |doi=  }}
*{{cite journal  | author=de Martin R, Haendler B, Hofer-Warbinek R, ''et al.'' |title=Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family. |journal=EMBO J. |volume=6 |issue= 12 |pages= 3673-7 |year= 1988 |pmid= 3322813 |doi=  }}
*{{cite journal  | author=Marquardt H, Lioubin MN, Ikeda T |title=Complete amino acid sequence of human transforming growth factor type beta 2. |journal=J. Biol. Chem. |volume=262 |issue= 25 |pages= 12127-31 |year= 1987 |pmid= 3476488 |doi=  }}
*{{cite journal  | author=Philip A, Bostedt L, Stigbrand T, O'Connor-McCourt MD |title=Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 687-93 |year= 1994 |pmid= 7513640 |doi=  }}
*{{cite journal  | author=Lin HY, Moustakas A, Knaus P, ''et al.'' |title=The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. |journal=J. Biol. Chem. |volume=270 |issue= 6 |pages= 2747-54 |year= 1995 |pmid= 7852346 |doi=  }}
*{{cite journal  | author=Hildebrand A, Romarís M, Rasmussen LM, ''et al.'' |title=Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. |journal=Biochem. J. |volume=302 ( Pt 2) |issue=  |pages= 527-34 |year= 1994 |pmid= 8093006 |doi=  }}
*{{cite journal  | author=López-Casillas F, Payne HM, Andres JL, Massagué J |title=Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. |journal=J. Cell Biol. |volume=124 |issue= 4 |pages= 557-68 |year= 1994 |pmid= 8106553 |doi=  }}
*{{cite journal  | author=Fromigué O, Marie PJ, Lomri A |title=Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. |journal=J. Cell. Biochem. |volume=68 |issue= 4 |pages= 411-26 |year= 1998 |pmid= 9493905 |doi=  }}
*{{cite journal  | author=Mori T, Kawara S, Shinozaki M, ''et al.'' |title=Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. |journal=J. Cell. Physiol. |volume=181 |issue= 1 |pages= 153-9 |year= 1999 |pmid= 10457363 |doi= 10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K }}
}}
{{refend}}

{{protein-stub}}

TGFBI

[edit]
  • INFO: Beginning work on TGFBI... {December 15, 2007 2:23:42 PM PST}
  • REDIRECT: Protein Redirected to: TGFBI {December 15, 2007 2:24:08 PM PST}
  • CREATED: Created new protein page: TGFBI {December 15, 2007 2:24:21 PM PST}

VCP

[edit]
  • INFO: Beginning work on VCP... {December 15, 2007 2:24:21 PM PST}
  • REDIRECT: Protein Redirected to: VCP (gene) {December 15, 2007 2:24:52 PM PST}
  • CREATED: Created new protein page: VCP (gene) {December 15, 2007 2:25:03 PM PST}

end log.

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