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Developmental and epileptic encephalopathies

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Developmental and epileptic encephalopathies (DEE), also known as early infantile epileptic encephalopathies (EIEE), are a group of rare developmental disorders characterised by early onset epilepsy and severe developmental delay. The epilepsy typically starts under 2 years of age and can be difficult to treat (intractable). One of the most common is Dravet syndrome which is commonly caused by mutation to SCN1A. However, in approximately 2/3 of people with DEE a genetic cause cannot currently be found.


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  1. ^ Cite error: The named reference aeui4 was invoked but never defined (see the help page).
  2. ^ Office for National Statistics (2020-04-20). "Deaths registered weekly in England and Wales, provisional - Office for National Statistics". www.ons.gov.uk. Retrieved 2020-04-20.