User:Synpath/sandbox

Synpath/sandbox
Clinical data
Pronunciation	/ˈmɔːrfiːn/
Trade names	Statex, MS Contin, Oramorph, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682133
License data	US DailyMed: Morphine;
Pregnancy; category	AU: C; ;
Dependence; liability	High
Addiction; liability	High
Routes of; administration	Inhalation (smoking), insufflation (snorting), by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal
Drug class	Opiate
ATC code	N02AA01 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage III (Special prescription form required); NZ: Class B; UK: POM (Prescription only) / Class A; US: Schedule II / Schedule III; UN: Narcotic Schedules I and III; EU: Rx-only;
Pharmacokinetic data
Bioavailability	20–40% (by mouth), 36–71% (rectally), 100% (IV/IM)
Protein binding	30–40%
Metabolism	Liver: UGT2B7
Metabolites	• Morphine-3-glucuronide (90%); • Morphine-6-glucuronide (10%)
Onset of action	5 minutes (IV), 15 minutes (IM), 20 minutes (PO)
Elimination half-life	2–3 hours
Duration of action	3–7 hours
Excretion	Kidney 90%, bile duct 10%
Identifiers
	IUPAC name (4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol;
CAS Number	57-27-2 ; 64-31-3 (neutral sulfate),; 52-26-6 (hydrochloride);
PubChem CID	5288826;
IUPHAR/BPS	1627;
DrugBank	DB00295 ;
ChemSpider	4450907 ;
UNII	76I7G6D29C;
KEGG	D08233 ;
ChEBI	CHEBI:17303 ;
ChEMBL	ChEMBL70 ;
PDB ligand	MOI (PDBe, RCSB PDB);
Chemical and physical data
Formula	C17H19NO3
Molar mass	285.343 g·mol−1
3D model (JSmol)	Interactive image;
Solubility in water	HCl & sulf.: 60
	SMILES CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5;
	InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 ; Key:BQJCRHHNABKAKU-KBQPJGBKSA-N ;
	(verify)

Synpath/sandbox
Synpath/sandbox
Drug class
	The RRR alpha-tocopherol form of vitamin E
Class identifiers
Use	Vitamin E deficiency, antioxidant
ATC code	A11HA03
Biological target	Reactive oxygen species
Clinical data
Drugs.com	MedFacts Natural Products
External links
MeSH	D014810
Legal status

This is the user sandbox of Synpath. A user sandbox is a subpage of the user's user page. It serves as a testing spot and page development space for the user and is not an encyclopedia article. Create or edit your own sandbox here.

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Template Test

infobox copied from Vitamin E to test adding ImageClass parameter

infobox copied from Morphine

Misc

The RCSB Molecule(s) of the Month are bacterial nanowires like PDB: 7qv7, hydrogen-dependent carbon dioxide reductase (HDCR) -> https://pdb101.rcsb.org/motm/290

I think these should be added to Nanowire as a separate section summarizing their function and structures and hatnote to the main article Bacterial nanowires where there is no current coverage of their structure.
Also consider adding PDB 7xkm to Molecular wire

Natural Nanowires

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Template	Angbr	"M"
Em space	⟨ ⟩	M M
En space	⟨ ⟩	M M
nb space	⟨ ⟩	M M
thin space	⟨ ⟩	M M
hair space	⟨ ⟩	M M

External links from Multiple sequence alignment

portals: GenomeNet EBI EMBNet

programs: PSAlign PRRN/PRRP CHAOS/DIALIGN M-COFFEE MergeAlign POA SAM MEME/MAST EDNA TCS

^ Cite error: The named reference drugs.com-page was invoked but never defined (see the help page).
^ "Morphine Use During Pregnancy". Drugs.com. 14 October 2019. Retrieved 21 August 2020.
^ Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 978-1-4557-0150-6.
^ "Morphine Product information". Health Canada. 9 August 2005. Retrieved 4 April 2024.
^ Cite error: The named reference Black's was invoked but never defined (see the help page).
^ "Sevredol Summary of Product Characteristics (SmPC)". (emc). 13 February 2024. Retrieved 20 February 2024.
^ "MS Contin- morphine sulfate tablet". DailyMed. 27 December 2023. Retrieved 20 February 2024.
^ "Modified-released oral opioids". European Medicines Agency. 18 November 2010. Retrieved 20 February 2024.
^ Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacology & Toxicology. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.
^ Whimster F (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.
^ Liben S (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.
^ Cite error: The named reference AHFS2015 was invoked but never defined (see the help page).
^ Cite error: The named reference Rockwood2009 was invoked but never defined (see the help page).

[drugs.com-page-1] Cite error: The named reference drugs.com-page was invoked but never defined (see the help page).

[Drugs.com_pregnancy-2] "Morphine Use During Pregnancy". Drugs.com. 14 October 2019. Retrieved 21 August 2020.

[3] Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 978-1-4557-0150-6.

[4] "Morphine Product information". Health Canada. 9 August 2005. Retrieved 4 April 2024.

[Black's-5] Cite error: The named reference Black's was invoked but never defined (see the help page).

[6] "Sevredol Summary of Product Characteristics (SmPC)". (emc). 13 February 2024. Retrieved 20 February 2024.

[7] "MS Contin- morphine sulfate tablet". DailyMed. 27 December 2023. Retrieved 20 February 2024.

[8] "Modified-released oral opioids". European Medicines Agency. 18 November 2010. Retrieved 20 February 2024.

[pmid3387374-9] Jonsson T, Christensen CB, Jordening H, Frølund C (April 1988). "The bioavailability of rectally administered morphine". Pharmacology & Toxicology. 62 (4): 203–5. doi:10.1111/j.1600-0773.1988.tb01872.x. PMID 3387374.

[10] Whimster F (1997). Cambridge textbook of accident and emergency medicine. Cambridge: Cambridge University Press. p. 191. ISBN 978-0-521-43379-2. Archived from the original on 8 September 2017.

[11] Liben S (2012). Oxford textbook of palliative care for children (2 ed.). Oxford: Oxford University Press. p. 240. ISBN 978-0-19-959510-5. Archived from the original on 8 September 2017.

[AHFS2015-12] Cite error: The named reference AHFS2015 was invoked but never defined (see the help page).

[Rockwood2009-13] Cite error: The named reference Rockwood2009 was invoked but never defined (see the help page).

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