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Cited Articles - Protein Biomarkers for the Diagnosis of Alzheimer's Disease

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The ability to treat Alzheimer's disease is greatly hindered by the lack of sensitive and specific diagnostic tools. Traditional diagnostic methods have an average accuracy of 70 to 80%, while others cannot definitively provide a diagnosis until post-mortem neuropathological tissue analysis[1]. There is a hotbed of research being conducted to change this bleak landscape for the growing number of people inflicted with the debilitating neurodegenerative disease. Based on the pathophysiology of the disease, a more sensitive diagnostic would be able to identify the disease 10 to 15 years before patients begin presenting with clinical symptoms[2]. A recent study aimed at developing an early diagnostic tool identified a panel of 37 protein biomarkers in cerebrospinal fluid that was able to improve the specificity of diagnosis of Alzheimer's disease when combined with established tau/amyloid-β42 ratios[2].

Summary of Characteristics of Target Article

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In this course, we'll be working a stub article to the status of a B class or GA (Good Article).

Stub Article

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A stub article provides a minimal description and is very basic in nature. It will leave most if not all readers wanting more information.

B Class Article

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B class articles are generally decent articles. They provide integral information and will not leave readers who are looking for a basic understanding wanting. However, erudite readers who want more comprehensive information, or a deeper dive into the topic, will require more details than the article provides. The article may also require additional citations and improvements to style.

Good Article (GA)

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GA articles have passed an official review and are considered high quality articles. They aren't as good as encyclopedia articles, but they're close. Some improvements may be realized after expert editing on subject and style or comparison to a Featured Article (FA) of a similar topic.

Wikipedia's 5 Pillars:

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There are five pillars that Wikipedia uses to guide editors' contributions. Following these pillars will help ensure that content on Wikipedia is appropriate.

  1. Wikipedia Is an Online Encyclopedia
    Wikipedia should be used to provide information in a structure similar to traditional encyclopedias and almanacs. Wikipedia is intended to present information in a specific format, it is not intended to be a dictionary, instruction manual or anything other than an encyclopedia. Wikipedia should not be used as a platform to advertise, proselytize or otherwise promote an editor's self-interests.
  2. Wikipedia Is Neutral
    Wikipedia can present different perspectives or opinions on the same topic, but the overall content in the article must be balanced, contextual and impartial.
  3. Wikipedia Is Free Content
    Wikipedia editors should be aware that any content they create and post on Wikipedia can be used by others. Wikipedia editors do not own the content they produce.
    Alternatively, editors should not plagiarize the content of others or violate any copyright laws.
  4. Wikipedia Editors Should Interact Respectfully and Civilly
    Wikipedia editors should avoid getting into editing wars with other authors. They should be respectful and civil when interacting with each other, even if they disagree. Lingering conflicts should be resolved using the talk page or, only if needed, the Wikipedia's dispute resolution process.
  5. Wikipedia Does Not Have Firm Rules
    Wikipedia provides guidelines to promote optimal content and editing, but those are subject to change and interpretation. Wikipedia encourages editors to be bold in their contributions and not get hung up on hard-lined rules. If mistakes are made, copies of the previous pages are kept and the pages can be reverted to previous versions if needed.

References

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  1. ^ Gearing, M (March 1995). "The Consortium to Establish a Registry for Alzheimer's Disease". Neurology. 3. 45 (1): 461–466. doi:10.1212/wnl.45.3.461. PMID 7898697. S2CID 41611865. Retrieved 20 February 2014. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  2. ^ a b Craig-Schapiro, Rebecca (Apr 2011). "Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis". PLOS ONE. 6. 19 (4). doi:10.1371 (inactive 2023-08-01). {{cite journal}}: Check |doi= value (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: DOI inactive as of August 2023 (link)