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Peer Review -Ramya

Hi Erica!

Abstract: The summary is very concise and hits all the main points asked in the rubric. There are some minor typos in here to watch out for. Mechanism: This gives a good idea of the symptoms that can be used for identifying MEERF. But it would be better if it was explained step-by-step (like a is causing b…. and it leads to MEERF). Maybe you could say more about the mechanism and how it leads to symptoms. And also a list of all the parts of the body that could be affected would be helpful. I know there must a lot but may be include some of the main ones that are affected.

Symptoms: looks like you listed all the symptoms. Maybe you could give a brief description and how it relates to MERRF

Diagnosis: it is descriptive and includes the molecular/regular testing methods for diagnosis. Also you used this section to include recent research findings. It might be helpful if you include what sort of genetic tests are done for MERRF and include any lifestyle indicators, if there are any subtypes for MERRF and the reasons for diagnosis

Causes and prevention: the beginning paragraph talks about the different mutations and how it is passed onto to generations –the point mutations part can go in the mechanism section that explains how MERRF unfolds. You may want to include that it does not spread from person to person. Also you a nice job of tying some symptoms in here.

Treatment and prognosis: This section has treatment options but prognosis is not there. Maybe something to add would be if lifestyle changes can help MERRF patients and if there are any other therapies other than the traditional treatments which can help

-Ramya

--Cfau47 (talk) 18:38, 14 November 2017 (UTC)[reply]

peer review: charles fausto

Thanks for doing an awesome job on your rough draft Erica! I actually learned a good amount just reading through. I particularly liked the way you did the hyperlinks via certain key words throughout your disease presentation (might have to talk to you about that technique!). Great illustrations included as well. Every point was hit pretty spot on just looking at the rubric, and I'm sure more will be fulfilled as you continue the research. Learning about your disease (which was pretty clear cut with the genes pinpointed) made me realize how not clear cut other chosen diseases are (mine included), in hindsight.

  • Excellent, clear abstract.
  • Good and consistent linking.
  • Mechanism section is more like symptoms. What do we know about the mechanism?
  • A lot of sections are only partially cited.
  • Diagnosis has a lot of great information, but doesn't have a flow. Can you make the organization clearer?
  • Missing recent research.
  • What's going on with the Ragged fibers section after everything else?
  • This is really close, just needs recent research, mechanisms and a little work on organization.

Sweiner02 (talk) 21:18, 26 November 2017 (UTC)[reply]