User talk:Hpfanatic

Question about Hypochlorous Acid Mechanism of Action

Hi, I'm a little confused on the Mechanism of Action section of Hypochlorous Acid. I think you wrote it, so just wondering if you could clear things up.

There are three sections: Inhibition of glucose oxidation, Depletion of adenine nucleotides, and Inhibition of DNA replication

Are ALL of these believed to be true at this, or are some ideas that were thought to be true at one point and are now disproven?

Do you know the certain parts of a cell hypochlorous acid attacks when it disinfects?

Thanks,

Nonie —Preceding unsigned comment added by Hpfanatic (talk • contribs) 00:03, 1 January 2008 (UTC)

Well yeah it it is a sort of a historical narrative as well. Having just read over it again, I think I can clear it up some more. The problem is finding time.

Basically there are a lot of reactions taking place, but the cell is already dead prior to most of them. It seems apparent that membrane bound ATPases are specifically inactivated in such a way as to uncouple the production of ATP from the proton motive force. Basically the ATPases become holes thru which protons can freely escape. This loss of energy, combined with the inability to form viable daughter cells due to loss of membrane proteins responsible for chromosomal segregation is fairly fatal. Both reactions happen early and at the same time as cell death. Other reactions described also occur but are postmortem. Specific info is covered in the references. In many cases, I can email articles, if your intensely interested.

That section need to be linked to other articles, and explained in simpler terms, but I tend to only have time for such things between post-doctoral jobs.