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VAV2

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VAV2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDsOMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134398
NM_003371

NM_009500

RefSeq (protein)

NP_001127870
NP_003362

NP_033526

Location (UCSC)Chr 9: 133.76 – 133.99 MbChr 2: 27.15 – 27.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[5][6]

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[6]

Interactions

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VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.[7] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1[7] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.[7] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner[8] and interact with CD19[9] and Grb2.[10][11]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160293Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009621Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. S2CID 27548854.
  6. ^ a b "Entrez Gene: VAV2 vav 2 oncogene".
  7. ^ a b c Marignani PA, Kanai F (2001-07-09). "Vav2 is required for cell spreading". The Journal of Cell Biology. 154 (1): 177–186. doi:10.1083/jcb.200103134. ISSN 0021-9525. PMC 2196856. PMID 11448999.
  8. ^ Arora PD, Marignani PA, McCulloch CA (July 2008). "Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2". American Journal of Physiology. Cell Physiology. 295 (1): C130–C137. doi:10.1152/ajpcell.00168.2008. ISSN 0363-6143. PMC 2493554. PMID 18434624.
  9. ^ Doody GM, Billadeau D D, Clayton E, Hutchings A, Berland R, McAdam S, Leibson P J, Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163.
  10. ^ Blagoev B, Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
  11. ^ Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton P A, Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.