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VPS24

From Wikipedia, the free encyclopedia
CHMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDsOMIM: 610052; MGI: 1913950; HomoloGene: 6368; GeneCards: CHMP3; OMA:CHMP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005753
NM_001193517
NM_016079

NM_025783
NM_001355674
NM_001355675
NM_001361405

RefSeq (protein)

NP_001005753
NP_001180446
NP_057163

NP_080059
NP_001342603
NP_001342604
NP_001348334

Location (UCSC)Chr 2: 86.5 – 86.56 MbChr 6: 71.52 – 71.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[5][6][7]

Function

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This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

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VPS24 has been shown to interact with IGFBP7.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115561Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053119Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab. 86 (9): 4504–11. doi:10.1210/jcem.86.9.7845. PMID 11549700.
  6. ^ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem. 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588.
  7. ^ a b "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)".

Further reading

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