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WDR4

From Wikipedia, the free encyclopedia
WDR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho
External IDsOMIM: 605924; MGI: 1889002; HomoloGene: 32422; GeneCards: WDR4; OMA:WDR4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021322

RefSeq (protein)

NP_067297

Location (UCSC)Chr 21: 42.84 – 42.88 MbChr 17: 31.71 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160193Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024037Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WDR4 WD repeat domain 4".

Further reading

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